Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts.

abstract：:The human multidrug resistance P-glycoprotein is an active transporter that pumps cytotoxic drugs out of cells. Expression of P-glycoprotein is also associated with a volume-activated chloride channel. Here we address the relationship between these two functions. Drug transport requires ATP hydrolysis while, in contra...

journal_title：Cell

authors： Gill DR,Hyde SC,Higgins CF,Valverde MA,Mintenig GM,Sepúlveda FV

更新日期：1992-10-02 00:00:00

abstract：:The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...

journal_title：Cell

authors： Gallay P,Swingler S,Song J,Bushman F,Trono D

更新日期：1995-11-17 00:00:00

abstract：:We describe a monoclonal antibody (anti-FC-1) that inhibits the attachment of chicken embryo fibroblasts to artificial substrates. In the immunofluorescence, anti-FC-1 also stained the focal contacts of the fibroblasts, organelles suggested to be involved in cell-substrate adhesion. This antibody was absorbed on the s...

journal_title：Cell

authors： Oesch B,Birchmeier W

更新日期：1982-12-01 00:00:00

abstract：:DMC1 is a new meiosis-specific yeast gene. Dmc1 protein is structurally similar to bacterial RecA proteins. dmc1 mutants are defective in reciprocal recombination, accumulate double-strand break (DSB) recombination intermediates, fail to form normal synaptonemal complex (SC), and arrest late in meiotic prophase. dmc1 ...

journal_title：Cell

authors： Bishop DK,Park D,Xu L,Kleckner N

更新日期：1992-05-01 00:00:00

abstract：:Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....

journal_title：Cell

authors： Cereghini S,Raymondjean M,Carranca AG,Herbomel P,Yaniv M

更新日期：1987-08-14 00:00:00

abstract：:A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group. Cotransfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-HCMV recombinant viruses that had incorporated overlapping se...

journal_title：Cell

authors： Boshart M,Weber F,Jahn G,Dorsch-Häsler K,Fleckenstein B,Schaffner W

更新日期：1985-06-01 00:00:00

abstract：:The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...

journal_title：Cell

authors： Tønnesen J,Inavalli VVGK,Nägerl UV

更新日期：2018-02-22 00:00:00

abstract：:Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...

journal_title：Cell

authors： Ojakian GK

更新日期：1981-01-01 00:00:00

abstract：:The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a mu chain but no detectable light chain. Aside from this mu-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. T...

journal_title：Cell

authors： Siden EJ,Baltimore D,Clark D,Rosenberg NE

更新日期：1979-02-01 00:00:00

abstract：:During yeast cell division, aggregates of damaged proteins are segregated asymmetrically between the bud and the mother. It is thought that protein aggregates are cleared from the bud via actin cable-based retrograde transport toward the mother and that Bni1p formin regulates this transport. Here, we examined the dyna...

journal_title：Cell

authors： Zhou C,Slaughter BD,Unruh JR,Eldakak A,Rubinstein B,Li R

更新日期：2011-11-23 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and re...

journal_title：Cell

authors： Gouwens NW,Sorensen SA,Baftizadeh F,Budzillo A,Lee BR,Jarsky T,Alfiler L,Baker K,Barkan E,Berry K,Bertagnolli D,Bickley K,Bomben J,Braun T,Brouner K,Casper T,Crichton K,Daigle TL,Dalley R,de Frates RA,Dee N,Dest

更新日期：2020-11-12 00:00:00

abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

journal_title：Cell

authors： Struhl G,Fitzgerald K,Greenwald I

更新日期：1993-07-30 00:00:00

abstract：:Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...

journal_title：Cell

authors： Kschonsak M,Merkel F,Bisht S,Metz J,Rybin V,Hassler M,Haering CH

更新日期：2017-10-19 00:00:00

abstract：:Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...

journal_title：Cell

authors： Winckler B

更新日期：2007-05-04 00:00:00

abstract：:The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...

journal_title：Cell

authors： Szekeres M,Németh K,Koncz-Kálmán Z,Mathur J,Kauschmann A,Altmann T,Rédei GP,Nagy F,Schell J,Koncz C

更新日期：1996-04-19 00:00:00

abstract：:The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rig...

journal_title：Cell

authors： Houdusse A,Kalabokis VN,Himmel D,Szent-Györgyi AG,Cohen C

更新日期：1999-05-14 00:00:00

abstract：:Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...

journal_title：Cell

authors： Athuluri-Divakar SK,Vasquez-Del Carpio R,Dutta K,Baker SJ,Cosenza SC,Basu I,Gupta YK,Reddy MV,Ueno L,Hart JR,Vogt PK,Mulholland D,Guha C,Aggarwal AK,Reddy EP

更新日期：2016-04-21 00:00:00

abstract：:In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an e...

journal_title：Cell

authors： Krimpenfort P,Berns A

更新日期：2015-06-18 00:00:00

abstract：:In contrast to uninfected chicken embryo fibroblasts (CEFs), CEFs infected with a retroviral vector that carries the v-erbA gene of avian erythroblastosis virus displayed new properties. These included limited anchorage-independent growth in soft agar, growth without latency in serum-supplemented medium, ability to ov...

journal_title：Cell

authors： Gandrillon O,Jurdic P,Benchaibi M,Xiao JH,Ghysdael J,Samarut J

更新日期：1987-06-05 00:00:00

abstract：:Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the...

journal_title：Cell

authors： Salmena L,Poliseno L,Tay Y,Kats L,Pandolfi PP

更新日期：2011-08-05 00:00:00

abstract：:Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...

journal_title：Cell

authors： Kempe TD,Swyryd EA,Bruist M,Stark GR

更新日期：1976-12-01 00:00:00

abstract：:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...

journal_title：Cell

authors： Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

更新日期：2011-10-14 00:00:00

abstract：:Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous system biology. We found that these genes display significantly higher rates of protein evolution in primates than in rodents. Impo...

journal_title：Cell

authors： Dorus S,Vallender EJ,Evans PD,Anderson JR,Gilbert SL,Mahowald M,Wyckoff GJ,Malcom CM,Lahn BT

更新日期：2004-12-29 00:00:00

abstract：:The transcriptional induction of heat shock genes is mediated by the heat shock transcription factor (HSF). We have investigated the oligomerization state of HSF from S. cerevisiae and find that it forms a trimer in solution and when bound to DNA. Trimerization is mediated by a region of HSF that, like the leucine zip...

journal_title：Cell

authors： Sorger PK,Nelson HC

更新日期：1989-12-01 00:00:00

abstract：:A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hyb...

journal_title：Cell

authors： Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJ

更新日期：1978-04-01 00:00:00

abstract：:Excessive accumulation of neurofilaments in the cell bodies and proximal axons of motor neurons is a major pathological hallmark during the early stages of many human motor neuron diseases. To test directly the consequence of overexpression of the major neurofilament subunit NF-L, we produced transgenic mice that accu...

journal_title：Cell

authors： Xu Z,Cork LC,Griffin JW,Cleveland DW

更新日期：1993-04-09 00:00:00

abstract：:Pulsed field gradient gel electrophoresis fractionates chromosome-sized DNA molecules from T. brucei. About 60% of the DNA remains in or close to the gel slot (large DNA). There are about three chromosomes of approximately 2 Mb, at least six chromosomes of 200-700 kb, and roughly a hundred mini-chromosomes of 50-150 k...

journal_title：Cell

authors： Van der Ploeg LH,Schwartz DC,Cantor CR,Borst P

更新日期：1984-05-01 00:00:00

abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...

journal_title：Cell

authors： Dimitrov DS

更新日期：2003-12-12 00:00:00

abstract：:Pseudotypes of vesicular stomatitis virus (VSV) and Moloney murine leukemia virus (MuLV), defined by their resistance to neutralization by anti-VSV antiserum, are released preferentially at early times after infection of MuLV-producing cells with VSV. At later times, after synthesis of MuLV proteins has been inhibited...

journal_title：Cell

authors： Witte ON,Baltimore D

更新日期：1977-07-01 00:00:00