Activation of STAT6 by STING is critical for antiviral innate immunity.


:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser(407) by TBK1 and Tyr(641), independent of JAKs. Phosphorylated STAT6 then dimerizes and translocates to the nucleus to induce specific target genes responsible for immune cell homing. Virus-induced STAT6 activation is detected in all cell-types tested, in contrast to the cell-type specific role of STAT6 in cytokine signaling, and Stat6(-/-) mice are susceptible to virus infection. Thus, STAT6 mediates immune signaling in response to both cytokines at the plasma membrane, and virus infection at the endoplasmic reticulum.






Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z




Has Abstract


2011-10-14 00:00:00
















  • Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation.

    abstract::Salmonella enterica invasion of host cells requires the reversible activation of the Rho-family GTPases Cdc42 and Rac1 by the bacterially encoded GEF SopE and the GAP SptP, which exert their function at different times during infection and are delivered into host cells by a type III secretion system. We found that Sop...


    pub_type: 杂志文章


    authors: Kubori T,Galán JE

    更新日期:2003-10-31 00:00:00

  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

    abstract::Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine receptors are the best-established target of antipsychotic drugs. Here we show that D2 class-receptor-mediated Akt regulation involves the formation of signaling complexes containing beta-arrestin 2, PP2A, and Akt. beta-arrestin 2...


    pub_type: 杂志文章


    authors: Beaulieu JM,Sotnikova TD,Marion S,Lefkowitz RJ,Gainetdinov RR,Caron MG

    更新日期:2005-07-29 00:00:00

  • Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.

    abstract::From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...


    pub_type: 杂志文章


    authors: Rheinwald JG,Green H

    更新日期:1975-11-01 00:00:00

  • Representation of the glomerular olfactory map in the Drosophila brain.

    abstract::We explored how the odor map in the Drosophila antennal lobe is represented in higher olfactory centers, the mushroom body and lateral horn. Systematic single-cell tracing of projection neurons (PNs) that send dendrites to specific glomeruli in the antennal lobe revealed their stereotypical axon branching patterns and...


    pub_type: 杂志文章


    authors: Marin EC,Jefferis GS,Komiyama T,Zhu H,Luo L

    更新日期:2002-04-19 00:00:00

  • Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity.

    abstract::Mouse macrophages and lymphocytes express two distinct isoforms of a single class of Fc receptor for IgG. The macrophage isoform (FcRII-B2) is identical to the lymphocyte isoform (FcRII-B1) except for an inframe insertion in the cytoplasmic tail of FcRII-B1 that increases its length from 47 to 94 amino acids. To deter...


    pub_type: 杂志文章


    authors: Miettinen HM,Rose JK,Mellman I

    更新日期:1989-07-28 00:00:00

  • ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.

    abstract::Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we report the purification of ARIA, a protein that stimulates the synthesis of muscle acetylcholine receptors, and the isolation of ARIA cDNA....


    pub_type: 杂志文章


    authors: Falls DL,Rosen KM,Corfas G,Lane WS,Fischbach GD

    更新日期:1993-03-12 00:00:00

  • Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

    abstract::The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and a...


    pub_type: 杂志文章


    authors: Sims TN,Soos TJ,Xenias HS,Dubin-Thaler B,Hofman JM,Waite JC,Cameron TO,Thomas VK,Varma R,Wiggins CH,Sheetz MP,Littman DR,Dustin ML

    更新日期:2007-05-18 00:00:00

  • A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.

    abstract::We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appre...


    pub_type: 杂志文章


    authors: Kappler JW,Wade T,White J,Kushnir E,Blackman M,Bill J,Roehm N,Marrack P

    更新日期:1987-04-24 00:00:00

  • Dancing with the host; flow-dependent bacterial adhesion.

    abstract::Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flo...


    pub_type: 杂志文章,评审


    authors: Isberg RR,Barnes P

    更新日期:2002-07-12 00:00:00

  • Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

    abstract::MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha and Dicer process the primary transcript (pri-miRNA) through a precursor hairpin (pre-miRNA) to the mature miRNA. The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) wit...


    pub_type: 杂志文章


    authors: Diederichs S,Haber DA

    更新日期:2007-12-14 00:00:00

  • "Cloaking" on Time: A Cover-Up Act by Resident Tissue Macrophages.

    abstract::In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell micro...


    pub_type: 评论,杂志文章


    authors: Blériot C,Ng LG,Ginhoux F

    更新日期:2019-04-18 00:00:00

  • The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. laevis.

    abstract::In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...


    pub_type: 杂志文章


    authors: Sollner-Webb B,Reeder RH

    更新日期:1979-10-01 00:00:00

  • SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

    abstract::We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production ...


    pub_type: 杂志文章


    authors: Fedor-Chaiken M,Deschenes RJ,Broach JR

    更新日期:1990-04-20 00:00:00

  • A DNA-dependent protease involved in DNA-protein crosslink repair.

    abstract::Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...


    pub_type: 杂志文章


    authors: Stingele J,Schwarz MS,Bloemeke N,Wolf PG,Jentsch S

    更新日期:2014-07-17 00:00:00

  • Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

    abstract::Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...


    pub_type: 杂志文章


    authors: Zou J,Guo Y,Guettouche T,Smith DF,Voellmy R

    更新日期:1998-08-21 00:00:00

  • A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it.

    abstract::Conditions are described for programming with active transcription complexes essentially all the Xenopus 5S RNA genes added to an extract of Xenopus oocyte nuclei. We call this rate enhancement. Transcription by SP6 RNA polymerase of either strand of a Xenopus 5S RNA gene is unimpeded by the presence of a complete tra...


    pub_type: 杂志文章


    authors: Wolffe AP,Jordan E,Brown DD

    更新日期:1986-02-14 00:00:00

  • Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

    abstract::Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...


    pub_type: 杂志文章


    authors: Sharabi K,Lin H,Tavares CDJ,Dominy JE,Camporez JP,Perry RJ,Schilling R,Rines AK,Lee J,Hickey M,Bennion M,Palmer M,Nag PP,Bittker JA,Perez J,Jedrychowski MP,Ozcan U,Gygi SP,Kamenecka TM,Shulman GI,Schreiber SL,Gr

    更新日期:2017-03-23 00:00:00

  • An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis.

    abstract::Competence development and sporulation in B. subtilis are partly controlled by peptides that accumulate in culture medium as cells grow to high density. We constructed two genes that encode mature forms of two different signaling molecules, the PhrA peptide that stimulates sporulation, and CSF, the competence- and spo...


    pub_type: 杂志文章


    authors: Lazazzera BA,Solomon JM,Grossman AD

    更新日期:1997-06-13 00:00:00

  • Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors.

    abstract::Steroid hormones induce transcription from the mouse mammary tumor virus (MMTV) promoter by complex mechanisms requiring binding of the hormone receptors to the hormone responsive element (HRE) of the long terminal repeat region. Here we show that the MMTV promoter contains two degenerated octamer motifs immediately u...


    pub_type: 杂志文章


    authors: Brüggemeier U,Kalff M,Franke S,Scheidereit C,Beato M

    更新日期:1991-02-08 00:00:00

  • Transcription of specific genes in isolated nuclei by exogenous RNA polymerases.

    abstract::Mouse plasmacytoma (MOPC) 460 cells contain two chromatographic forms of RNA polymerase III (IIIA and IIIB) in addition to the major class I and II RNA polymerases. Nuclei isolated from these cells actively synthesize RNA. Among the discrete transcription products observed are the 5S and 4.5S RNAs and additional low m...


    pub_type: 杂志文章


    authors: Sklar VE,Roeder RG

    更新日期:1977-03-01 00:00:00

  • Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.

    abstract::Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...


    pub_type: 杂志文章


    authors: Goddard LM,Murphy TJ,Org T,Enciso JM,Hashimoto-Partyka MK,Warren CM,Domigan CK,McDonald AI,He H,Sanchez LA,Allen NC,Orsenigo F,Chao LC,Dejana E,Tontonoz P,Mikkola HK,Iruela-Arispe ML

    更新日期:2014-01-30 00:00:00

  • Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies.

    abstract::We have prepared three monoclonal antibodies against human epidermal keratins. These antibodies were highly specific for keratins and, in combination, recognized all major epidermal keratins of several mammalian species. We have used these antibodies to study the tissue distribution of epidermis-related keratins. In v...


    pub_type: 杂志文章


    authors: Tseng SC,Jarvinen MJ,Nelson WG,Huang JW,Woodcock-Mitchell J,Sun TT

    更新日期:1982-09-01 00:00:00

  • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

    abstract::Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established. Here we demonstrate that this link occurs through direct binding of 53BP1 and ...


    pub_type: 杂志文章


    authors: Botuyan MV,Lee J,Ward IM,Kim JE,Thompson JR,Chen J,Mer G

    更新日期:2006-12-29 00:00:00

  • A unique pattern of integrated viral genes in hamster cells transformed by highly oncogenic human adenovirus 12.

    abstract::We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...


    pub_type: 杂志文章


    authors: Green MR,Chinnadurai G,Mackey JK,Green M

    更新日期:1976-03-01 00:00:00

  • The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

    abstract::The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-...


    pub_type: 杂志文章


    authors: Rothe M,Pan MG,Henzel WJ,Ayres TM,Goeddel DV

    更新日期:1995-12-29 00:00:00

  • The interaction of recombination proteins with supercoiled DNA: defining the role of supercoiling in lambda integrative recombination.

    abstract::Lambda integrative recombination depends on supercoiling of the phage attachment site, attP. Using dimethylsulfate protection and indirect end-labeling, the interaction of the recombination proteins Int and IHF with supercoiled and linear attP has been studied. Supercoiling enhances the binding of Int to attP, but not...


    pub_type: 杂志文章


    authors: Richet E,Abcarian P,Nash HA

    更新日期:1986-09-26 00:00:00

  • Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin.

    abstract::Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...


    pub_type: 杂志文章,收录出版


    authors: Chan SK,Struhl G

    更新日期:2002-10-18 00:00:00

  • Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.

    abstract::During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...


    pub_type: 杂志文章


    authors: Baker CC,Herisse J,Courtois G,Galibert F,Ziff E

    更新日期:1979-10-01 00:00:00

  • A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

    abstract::Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of human mammary epithelial organoids. Using this protocol, >100 primary and metastatic BC organoid lines were generated, broadly recapitulating t...


    pub_type: 杂志文章


    authors: Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan

    更新日期:2018-01-11 00:00:00

  • A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant.

    abstract::Mutations in the C. elegans gene ced-3 prevent almost all programmed cell deaths, so that in a ced-3 mutant there are many extra cells. We show that the pharyngeal neuron M4 is essential for feeding in wild-type worms, but in a ced-3 mutant, one of the extra cells, probably MSpaaaaap (the sister of M4), can sometimes ...


    pub_type: 杂志文章


    authors: Avery L,Horvitz HR

    更新日期:1987-12-24 00:00:00