Abstract：
:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection.
journal_name
Celljournal_title
Cellauthors
Kaech SM,Hemby S,Kersh E,Ahmed Rdoi
10.1016/s0092-8674(02)01139-xsubject
Has Abstractpub_date
2002-12-13 00:00:00pages
837-51issue
6eissn
0092-8674issn
1097-4172pii
S009286740201139Xjournal_volume
111pub_type
杂志文章相关文献
CELL文献大全abstract：:Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. It has been thought that small-molecule mimetics of Smac, an endogenous IAP antagonist, might potentiate apoptosis in cancer cells by promoting caspase activation. However, three recent papers, two in Cell (Vinc...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.10.042
更新日期：2007-11-16 00:00:00
abstract：:We have identified and analyzed a meiotic reciprocal recombination hot spot in S. cerevisiae. We find that double-strand breaks occur at two specific sites associated with the hot spot and that occurrence of these breaks depends upon meiotic recombination functions RAD50 and SPO11. Furthermore, these breaks occur in a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90072-m
更新日期：1990-06-15 00:00:00
abstract：:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.06.002
更新日期：2014-06-19 00:00:00
abstract：:Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81402-6
更新日期：1998-03-20 00:00:00
abstract：:The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.07.017
更新日期：2017-07-27 00:00:00
abstract：:5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 75 muM) inhibited only 60-75% of nuclear heterogeneous RNA (hnRNA) synthesis in HeLa cells, while the appearance of labeled cytoplasmic poly(A)-containing messenger RNA (mRNA) was reduced by approximately 95%. DRB-sensitive and resistant transcripts spanned the e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90092-1
更新日期：1976-11-01 00:00:00
abstract：:Developmental signaling pathways needed to evolve to be robust against environmental fluctuations. In this issue, Shimizu et al. reveal a complex system of interacting endocytic pathways that help to maintain consistent levels of Notch activity across a range of temperatures. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2014.05.007
更新日期：2014-05-22 00:00:00
abstract：:The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/s0092-8674(03)00888-2
更新日期：2003-11-14 00:00:00
abstract：:The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how conf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.007
更新日期：2015-02-12 00:00:00
abstract：:The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage lambda and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent alpha helix in N recognizes primarily the shape and negatively charged surface of the boxB hairpin through...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81579-2
更新日期：1998-04-17 00:00:00
abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.026
更新日期：2013-10-10 00:00:00
abstract：:Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.03.002
更新日期：2017-03-23 00:00:00
abstract：:We report here the identification of thyroid hormone response elements (TREs) that consist of a direct repeat, not a palindrome, of the half-sites. Unlike palindromic TREs, direct repeat TREs do not confer a retinoic acid response. The tandem TRE can be converted into a retinoic acid response element by increasing the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90020-y
更新日期：1991-06-28 00:00:00
abstract：:Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain plasticity and function, however, remain unclear. To address this question, we generated CX3CR1(CreER) mice expressing tamoxifen-inducible Cre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.11.030
更新日期：2013-12-19 00:00:00
abstract：:We have examined the conformation of DNA cloned from the hypersensitive region 5' of the chicken adult beta-globin gene, in order to determine whether the unusual sensitivity to nucleases is related to altered secondary structure of the DNA. The region contains a large number of sites for methylation; we have studied ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90180-0
更新日期：1983-12-01 00:00:00
abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90095-8
更新日期：1983-12-01 00:00:00
abstract：:We have analyzed the generation of unexpected patterns of RNA editing, i.e., those not following a strict 3' to 5' progression, which occur in junction regions between fully edited and preedited sequences. Evidence is presented that these patterns are generated by misediting due to specific events of misguiding. Mised...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90171-8
更新日期：1992-08-07 00:00:00
abstract：:Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Al...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2010.02.016
更新日期：2010-03-19 00:00:00
abstract：:We show that expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme. Expression is reduced at least 200-fold in cells grown under conditions of heme deficiency. Studies on the regulation of a CYC1-lacZ fused gene and direct determination of mRN...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90309-4
更新日期：1983-04-01 00:00:00
abstract：:The tra-1 gene plays a central role in C. elegans sex determination. XX animals develop as hermaphrodites when tra-1 is active and as males when it is not. By analyzing a large number of tra-1 genetic mosaics we have shown that, with the expected exception of vulval induction by the hermaphrodite gonad, tra-1 function...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90415-b
更新日期：1990-12-21 00:00:00
abstract：:Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2013.08.040
更新日期：2013-09-12 00:00:00
abstract：:KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.01.006
更新日期：2018-01-25 00:00:00
abstract：:The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tiss...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01087-5
更新日期：2002-11-27 00:00:00
abstract：:Voluntary movement is a result of signals transmitted through a communication channel that links the internal world in our minds to the physical world around us. Intention can be considered the desire to effect change on our environment, and this is contained in the signals from the brain, passed through the nervous s...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.02.038
更新日期：2016-03-10 00:00:00
abstract：:Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80592-9
更新日期：1999-03-19 00:00:00
abstract：:Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)00965-0
更新日期：2002-09-20 00:00:00
abstract：:The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.04.015
更新日期：2005-07-01 00:00:00
abstract：:A mutant in src, the oncogene of Rous sarcoma virus, has been constructed in which the major phosphorylated tyrosine (Tyr-416, located in the carboxy-terminal half of the protein) has been replaced by phenylalanine. Mouse cells transformed with this mutant src form foci and grow in soft agar, indicative of a transform...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90074-0
更新日期：1983-03-01 00:00:00
abstract：:The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00607-9
更新日期：2001-12-28 00:00:00
abstract：:Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.08.011
更新日期：2019-09-19 00:00:00
