Abstract：
:We report here the identification of thyroid hormone response elements (TREs) that consist of a direct repeat, not a palindrome, of the half-sites. Unlike palindromic TREs, direct repeat TREs do not confer a retinoic acid response. The tandem TRE can be converted into a retinoic acid response element by increasing the spacing between the half-sites by 1 nucleotide, and the resulting retinoic acid response element is no longer a TRE. Decreasing the half-site spacing by 1 nucleotide converts the TRE to a vitamin D3 response element, while eliminating response to T3. These results correlate well with DNA-binding affinities of the thyroid hormone, retinoic acid, and vitamin D3 receptors. This study points to the general importance of tandem repeat hormone response elements and suggests a simple physiologic code exists in which half-site spacing plays a critical role in achieving selective hormonal response.
journal_name
Celljournal_title
Cellauthors
Umesono K,Murakami KK,Thompson CC,Evans RMdoi
10.1016/0092-8674(91)90020-ysubject
Has Abstractpub_date
1991-06-28 00:00:00pages
1255-66issue
7eissn
0092-8674issn
1097-4172pii
0092-8674(91)90020-Yjournal_volume
65pub_type
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