Abstract：
:MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained from lean mice improve glucose tolerance and insulin sensitivity when administered to obese recipients. miR-155 is one of the miRNAs overexpressed in obese ATM Exos, and earlier studies have shown that PPARγ is a miR-155 target. Our results show that miR-155KO animals are insulin sensitive and glucose tolerant compared to controls. Furthermore, transplantation of WT bone marrow into miR-155KO mice mitigated this phenotype. Taken together, these studies show that ATMs secrete exosomes containing miRNA cargo. These miRNAs can be transferred to insulin target cell types through mechanisms of paracrine or endocrine regulation with robust effects on cellular insulin action, in vivo insulin sensitivity, and overall glucose homeostasis.
journal_name
Celljournal_title
Cellauthors
Ying W,Riopel M,Bandyopadhyay G,Dong Y,Birmingham A,Seo JB,Ofrecio JM,Wollam J,Hernandez-Carretero A,Fu W,Li P,Olefsky JMdoi
10.1016/j.cell.2017.08.035subject
Has Abstractpub_date
2017-10-05 00:00:00pages
372-384.e12issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(17)30993-5journal_volume
171pub_type
杂志文章相关文献
CELL文献大全abstract：:The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.004
更新日期：2004-12-17 00:00:00
abstract：:The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor components, CNTFR alpha, is expressed by skeletal muscle. Here we show that the other CNTF receptor components, LIFR beta and gp130, are also expressed by skeletal mu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90113-9
更新日期：1994-02-11 00:00:00
abstract：:We have examined the conformation of DNA cloned from the hypersensitive region 5' of the chicken adult beta-globin gene, in order to determine whether the unusual sensitivity to nucleases is related to altered secondary structure of the DNA. The region contains a large number of sites for methylation; we have studied ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90180-0
更新日期：1983-12-01 00:00:00
abstract：:The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex. Direct interaction of Vpr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.011
更新日期：2014-01-16 00:00:00
abstract：:The rate of incorporation of leucine into protein, the rate of polypeptide elongation and termination, and the relative quantity and size of polysomes were analyzed in mouse L cells grown in suspension culture at various temperatures between 0 degrees C and 36 degrees C. Between 10 degrees C and 36 degrees C protein s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90153-1
更新日期：1975-04-01 00:00:00
abstract：:The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90145-8
更新日期：1981-02-01 00:00:00
abstract：:We have analyzed two mutations of the white-eye gene, which arose in flies subject to I-R hybrid dysgenesis. These mutations are associated with insertions of apparently identical 5.4 kb sequences, which we have cloned. We believe that these insertions are copies of the I factor controlling I-R hybrid dysgenesis. The ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90536-1
更新日期：1984-08-01 00:00:00
abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.08.020
更新日期：2006-09-08 00:00:00
abstract：:247 independent events involving insertion of the TN3 transposable element into a 4 kb constructed plasmid (pTU4) of partially known DNA sequence were studied by restriction endonuclease mapping, and 65 of these insertion sites were examined further by DNA sequence analysis. Our results show that the previously propos...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90396-7
更新日期：1980-01-01 00:00:00
abstract：:Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.08.015
更新日期：2016-08-25 00:00:00
abstract：:Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins. Assembly of this essential organelle occurs outside the cytoplasm in an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.02.015
更新日期：2005-04-22 00:00:00
abstract：:Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80437-7
更新日期：1997-11-14 00:00:00
abstract：:Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.04.018
更新日期：2016-05-19 00:00:00
abstract：:Telomeres are thought to be maintained by the preferential recruitment of telomerase to the shortest telomeres. The extension of the G-rich telomeric strand by telomerase is also believed to be coordinated with the complementary synthesis of the C strand by the conventional replication machinery. However, we show that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.05.026
更新日期：2009-08-07 00:00:00
abstract：:Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.04.034
更新日期：2018-06-14 00:00:00
abstract：:A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.04.051
更新日期：2008-07-11 00:00:00
abstract：:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90593-3
更新日期：1986-11-07 00:00:00
abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.09.001
更新日期：2012-09-28 00:00:00
abstract：:Two independent approaches to understanding the molecular mechanism of cytokinesis have converged on the gene spaghetti-squash (sqh). A genetic screen for mitotic mutants identified sqh1, a mutation that disrupts cytokinesis, which was then cloned by transposon tagging. Independently, the gene that encodes the regulat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90013-o
更新日期：1991-06-28 00:00:00
abstract：:The small ribonucleoproteins recognized by anti-La autoantibodies contain a heterogeneous mixture of small RNAs from uninfected mammalian cells. The identity of many of these has now been established by the discovery of precursor forms of 5S rRNA and of certain tRNAs among La RNAs from HeLa cells. The small fraction o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90099-x
更新日期：1982-05-01 00:00:00
abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2006.02.001
更新日期：2006-02-24 00:00:00
abstract：:We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81029-6
更新日期：1996-02-23 00:00:00
abstract：:AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.07.045
更新日期：2017-09-07 00:00:00
abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.11.004
更新日期：2008-11-28 00:00:00
abstract：:The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how conf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.007
更新日期：2015-02-12 00:00:00
abstract：:To search for histone domains that may regulate transcription in vivo, we made deletions and amino acid substitutions in the histone N-termini of S. cerevisiae. Histone H4 N-terminal residues 4-23, which include the extremely conserved, reversibly acetylated lysines (at positions 5, 8, 12, and 16), were found to encom...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90554-c
更新日期：1991-06-14 00:00:00
abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.08.005
更新日期：2015-08-27 00:00:00
abstract：:We have isolated and characterized several members of the P transposable element family from a Drosophila melanogaster P strain. Large 2.9 kb elements are present as multiple highly conserved copies together with smaller (0.5-1.6 kb), heterogeneous elements. The complete DNA sequences of the 2.9 kb element and four sm...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90133-2
更新日期：1983-08-01 00:00:00
abstract：:Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated. RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. These defects were...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90246-m
更新日期：1993-05-21 00:00:00
abstract：:Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, bu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.10.033
更新日期：2012-11-09 00:00:00
