Effect of reduced temperatures on protein synthesis in mouse L cells.

abstract：:In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development. These RNAs then target complementary DNA for elimination in a positive feedback process, contributing to germline defense...

journal_title：Cell

authors： Allen SE,Hug I,Pabian S,Rzeszutek I,Hoehener C,Nowacki M

更新日期：2017-03-09 00:00:00

abstract：:An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...

journal_title：Cell

authors： Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jin

更新日期：2013-02-14 00:00:00

abstract：:Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...

journal_title：Cell

authors： Athuluri-Divakar SK,Vasquez-Del Carpio R,Dutta K,Baker SJ,Cosenza SC,Basu I,Gupta YK,Reddy MV,Ueno L,Hart JR,Vogt PK,Mulholland D,Guha C,Aggarwal AK,Reddy EP

更新日期：2016-04-21 00:00:00

abstract：:Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...

journal_title：Cell

authors： Kastan MB,Gowans BJ,Lieberman MW

更新日期：1982-09-01 00:00:00

abstract：:Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...

journal_title：Cell

authors： Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC

更新日期：2017-03-09 00:00:00

abstract：:The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. ...

journal_title：Cell

authors： Wybenga-Groot LE,Baskin B,Ong SH,Tong J,Pawson T,Sicheri F

更新日期：2001-09-21 00:00:00

abstract：:The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...

journal_title：Cell

authors： Meiklejohn AL,Gralla JD

更新日期：1985-12-01 00:00:00

abstract：:White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we ...

journal_title：Cell

authors： Chun TH,Hotary KB,Sabeh F,Saltiel AR,Allen ED,Weiss SJ

更新日期：2006-05-05 00:00:00

abstract：:Regulatory T cells (Tregs) play a pivotal role in the inhibition of anti-tumor immune responses. Understanding the mechanisms governing Treg homeostasis may therefore be important for development of effective tumor immunotherapy. We have recently demonstrated a key role for the canonical nuclear factor κB (NF-κB) subu...

journal_title：Cell

authors： Grinberg-Bleyer Y,Oh H,Desrichard A,Bhatt DM,Caron R,Chan TA,Schmid RM,Klein U,Hayden MS,Ghosh S

更新日期：2017-09-07 00:00:00

abstract：:Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response. The best known of these are probably the Toll-like receptors, but a number of other receptors are also involved. Several of these re...

journal_title：Cell

authors： Gordon S

更新日期：2002-12-27 00:00:00

abstract：:Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interac...

journal_title：Cell

authors： Andalman AS,Burns VM,Lovett-Barron M,Broxton M,Poole B,Yang SJ,Grosenick L,Lerner TN,Chen R,Benster T,Mourrain P,Levoy M,Rajan K,Deisseroth K

更新日期：2019-05-02 00:00:00

abstract：:Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that the Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade t...

journal_title：Cell

authors： Gujral TS,Chan M,Peshkin L,Sorger PK,Kirschner MW,MacBeath G

更新日期：2014-11-06 00:00:00

abstract：:We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...

journal_title：Cell

authors： Miyazaki T,Wolf P,Tourne S,Waltzinger C,Dierich A,Barois N,Ploegh H,Benoist C,Mathis D

更新日期：1996-02-23 00:00:00

abstract：:NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further reduction in worm lifespan. Conversely, genetic or pharmacological...

journal_title：Cell

authors： Mouchiroud L,Houtkooper RH,Moullan N,Katsyuba E,Ryu D,Cantó C,Mottis A,Jo YS,Viswanathan M,Schoonjans K,Guarente L,Auwerx J

更新日期：2013-07-18 00:00:00

abstract：:Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reverse...

journal_title：Cell

authors： Radic MZ,Lundgren K,Hamkalo BA

更新日期：1987-09-25 00:00:00

abstract：:Escherichia coli and Micrococcus luteus DNA topoisomerase I are found to promote catenation of double-stranded DNA rings. At low DNA concentration dimeric catenanes are the major catenated products; at high DNA concentration or when spermidine is present, catenanes containing more than two rings are formed. There is n...

journal_title：Cell

authors： Tse Y,Wang JC

更新日期：1980-11-01 00:00:00

abstract：:Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chr...

journal_title：Cell

authors： Liu X,Zhang Y,Chen Y,Li M,Zhou F,Li K,Cao H,Ni M,Liu Y,Gu Z,Dickerson KE,Xie S,Hon GC,Xuan Z,Zhang MQ,Shao Z,Xu J

更新日期：2017-08-24 00:00:00

abstract：:A new type of mutation that affects a discrete step in the process of adsorptive endocytosis has been identified in one of 22 strains of fibroblasts derived from subjects with the clinical phenotype of homozygous familial hypercholesterolemia (FH). In this unique mutant strain (derived from subject J.D.), the cell sur...

journal_title：Cell

authors： Brown MS,Goldstein JL

更新日期：1976-12-01 00:00:00

abstract：:The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor ...

journal_title：Cell

authors： Yokoyama A,Somervaille TC,Smith KS,Rozenblatt-Rosen O,Meyerson M,Cleary ML

更新日期：2005-10-21 00:00:00

abstract：:Using a combination of classical genetics, serology, and molecular genetics, we have mapped as many as possible of the MHC components in t haplotypes. Results indicate that the whole MHC is included in a simple inversion with the relative positions of its genes being intact. Furthermore, some of the t-lethal mutations...

journal_title：Cell

authors： Shin HS,Bennett D,Artzt K

更新日期：1984-12-01 00:00:00

abstract：:The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are simil...

journal_title：Cell

authors： O'Connor CM,Gard DL,Lazarides E

更新日期：1981-01-01 00:00:00

abstract：:Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his a...

journal_title：Cell

authors： Larson MH,Greenleaf WJ,Landick R,Block SM

更新日期：2008-03-21 00:00:00

abstract：:The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infect...

journal_title：Cell

authors： Sette A,Crotty S

更新日期：2021-01-12 00:00:00

abstract：:Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...

journal_title：Cell

authors： Bonetta L

更新日期：2009-10-30 00:00:00

abstract：:Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies. However, sources and mechanisms that generate tumor heterogeneity and drug-resistant cell population are still unfolding. Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-β-activated sq...

journal_title：Cell

authors： Oshimori N,Oristian D,Fuchs E

更新日期：2015-02-26 00:00:00

abstract：:A major problem in treatment of cancers arising in steroid-sensitive cells is their inevitable progression to a steroid-insensitive state; current therapies are based on the assumption that hormone insensitivity is associated with loss of receptor. We demonstrate for the first time that breast tumor cells can progress...

journal_title：Cell

authors： Darbre PD,King RJ

更新日期：1987-11-20 00:00:00

abstract：:To determine the special feature of ribosomal RNA promoters that might account for the highly efficient and regulated synthesis of rRNA in E. coli, we have analyzed the beginnings of two ribosomal RNA operons, rrnD and rrnX. DNA sequences for 425 bp preceding those specifying mature 16s rRNA are reported. In vitro tra...

journal_title：Cell

authors： Young RA,Steitz JA

更新日期：1979-05-01 00:00:00

abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...

journal_title：Cell

authors： Malhotra V

更新日期：2012-03-30 00:00:00

abstract：:Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry, and cellular microscopy that VP40 rearranges into different structures, each with a distinct function required for...

journal_title：Cell

authors： Bornholdt ZA,Noda T,Abelson DM,Halfmann P,Wood MR,Kawaoka Y,Saphire EO

更新日期：2013-08-15 00:00:00

abstract：:RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for th...

journal_title：Cell

authors： Carter J,Hoffman C,Wiedenheft B

更新日期：2017-01-12 00:00:00