Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle.

abstract：:The temperature-sensitive mutant of yeast, rna2-, when incubated at the nonpermissive temperature, has a qualitatively distinct distribution of mRNA sequences as compared to wild-type. Quantitative comparison with the wild-type distribution indicates that after 1 hr at the nonpermissive temperature, the concentration ...

journal_title：Cell

authors： Hereford LM,Rosbash M

更新日期：1977-03-01 00:00:00

abstract：:Hybrid plasmid molecules containing tandemly repeated Drosophila satellite DNA were constructed using a modification of the (dA)-(dT) homopolymer procedure of Lobban and Kaiser (1973). Recombinant plasmids recovered after transformation of recA bacteria contained 10% of the amount of satellite DNA present in the trans...

journal_title：Cell

authors： Brutlag D,Fry K,Nelson T,Hung P

更新日期：1977-03-01 00:00:00

abstract：:Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient r...

journal_title：Cell

authors： Cohn RD,Henry MD,Michele DE,Barresi R,Saito F,Moore SA,Flanagan JD,Skwarchuk MW,Robbins ME,Mendell JR,Williamson RA,Campbell KP

更新日期：2002-09-06 00:00:00

abstract：:Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...

journal_title：Cell

authors： Patnode ML,Beller ZW,Han ND,Cheng J,Peters SL,Terrapon N,Henrissat B,Le Gall S,Saulnier L,Hayashi DK,Meynier A,Vinoy S,Giannone RJ,Hettich RL,Gordon JI

更新日期：2019-09-19 00:00:00

abstract：:Two independent approaches to understanding the molecular mechanism of cytokinesis have converged on the gene spaghetti-squash (sqh). A genetic screen for mitotic mutants identified sqh1, a mutation that disrupts cytokinesis, which was then cloned by transposon tagging. Independently, the gene that encodes the regulat...

journal_title：Cell

authors： Karess RE,Chang XJ,Edwards KA,Kulkarni S,Aguilera I,Kiehart DP

更新日期：1991-06-28 00:00:00

abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...

journal_title：Cell

authors： Bates P,Young JA,Varmus HE

更新日期：1993-09-24 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...

journal_title：Cell

authors： Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RA

更新日期：1999-12-10 00:00:00

abstract：:The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...

journal_title：Cell

authors： Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD

更新日期：2014-06-05 00:00:00

abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...

journal_title：Cell

authors： Fowler DM,Kelly JW

更新日期：2009-04-03 00:00:00

abstract：:Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...

journal_title：Cell

authors： Tanaka K,Appella E,Jay G

更新日期：1983-12-01 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:Interneurons in the neocortex of the brain are small, locally projecting inhibitory GABAergic cells with a broad array of anatomical and physiological properties. The diversity of interneurons is believed to be crucial for regulating myriad operations in the neocortex. Here, we describe current theories about how inte...

journal_title：Cell

authors： Moore CI,Carlen M,Knoblich U,Cardin JA

更新日期：2010-07-23 00:00:00

abstract：:The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding domains and thereby assist in driving the formation of cancerous cells. In the context of the translocated fusion proteins, these LC sequences fu...

journal_title：Cell

authors： Kwon I,Kato M,Xiang S,Wu L,Theodoropoulos P,Mirzaei H,Han T,Xie S,Corden JL,McKnight SL

更新日期：2013-11-21 00:00:00

abstract：:In this issue of Cell, Coppens and coworkers (Coppens et al., 2006) describe how Toxoplasma gondii, an obligate intracellular parasite, feeds on the host. Coppens et al. provide evidence that the parasite takes host cell endosomes and lysosomes hostage by sequestering them where the parasite resides, within invaginati...

journal_title：Cell

authors： Gruenberg J,van der Goot FG

更新日期：2006-04-21 00:00:00

abstract：:Animals learn to avoid harmful situations by associating a neutral stimulus with a painful one, resulting in a stable threat memory. In mammals, this form of learning requires the amygdala. Although pain is the main driver of aversive learning, the mechanism that transmits pain signals to the amygdala is not well reso...

journal_title：Cell

authors： Han S,Soleiman MT,Soden ME,Zweifel LS,Palmiter RD

更新日期：2015-07-16 00:00:00

abstract：:RORγt(+) Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and produce IL-17 cytokines. Segmented filamentous bacteria (SFB) are Th17-inducing commensals that potentiate autoimmunity in mice. RORγt(+) T cells were induced...

journal_title：Cell

authors： Sano T,Huang W,Hall JA,Yang Y,Chen A,Gavzy SJ,Lee JY,Ziel JW,Miraldi ER,Domingos AI,Bonneau R,Littman DR

更新日期：2015-10-08 00:00:00

abstract：:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host ...

journal_title：Cell

authors： Ginocchio CC,Olmsted SB,Wells CL,Galán JE

更新日期：1994-02-25 00:00:00

abstract：:The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...

journal_title：Cell

authors： Deverman BE,Cook BL,Manson SR,Niederhoff RA,Langer EM,Rosová I,Kulans LA,Fu X,Weinberg JS,Heinecke JW,Roth KA,Weintraub SJ

更新日期：2002-10-04 00:00:00

abstract：:The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...

journal_title：Cell

authors： Marchese FP,Huarte M

更新日期：2018-05-31 00:00:00

abstract：:The mysterious secrets of long noncoding RNAs, often referred to as the Dark Matter of the genome, are gradually coming to light. Several recent papers dig deep to reveal surprisingly complex and diverse functions of these enigmatic molecules. ...

journal_title：Cell

authors： Nagano T,Fraser P

更新日期：2011-04-15 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...

journal_title：Cell

authors： Harford AG,Zuchowski CI

更新日期：1977-06-01 00:00:00

abstract：:In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...

journal_title：Cell

authors： Suganuma T,Mushegian A,Swanson SK,Abmayr SM,Florens L,Washburn MP,Workman JL

更新日期：2010-09-03 00:00:00

abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...

journal_title：Cell

authors： Bienz M,Gurdon JB

更新日期：1982-07-01 00:00:00

abstract：:Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 20...

journal_title：Cell

authors： Edvinsson L

更新日期：2018-12-13 00:00:00

abstract：:Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here. ...

journal_title：Cell

authors： Borst P

更新日期：2002-04-05 00:00:00

abstract：:The Drosophila transforming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a long-range concentration gradient to direct the anteroposterior patterning of the wing. Both planar transcytosis initiated by Dynamin-mediated endocytosis and extracellular diffusion have been propo...

journal_title：Cell

authors： Belenkaya TY,Han C,Yan D,Opoka RJ,Khodoun M,Liu H,Lin X

更新日期：2004-10-15 00:00:00

abstract：:To determine the structural features responsible for the curvature of kinetoplast DNA, we studied 13 adenine tracts in Crithidia fasciculata kinetoplast DNA. The structures of the A tracts were analyzed by cutting the DNA with hydroxyl radical. Reactivity of hydroxyl radical toward the DNA backbone progressively decre...

journal_title：Cell

authors： Burkhoff AM,Tullius TD

更新日期：1987-03-27 00:00:00

abstract：:Enhancers provide critical information directing cell-type-specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here, we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-recruitment and in ...

journal_title：Cell

authors： Liu Z,Merkurjev D,Yang F,Li W,Oh S,Friedman MJ,Song X,Zhang F,Ma Q,Ohgi KA,Krones A,Rosenfeld MG

更新日期：2014-10-09 00:00:00