Abstract:
:An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in central China approximately 30,000 years ago. Although EDAR370A has been associated with increased scalp hair thickness and changed tooth morphology in humans, its direct biological significance and potential adaptive role remain unclear. We generated a knockin mouse model and find that, as in humans, hair thickness is increased in EDAR370A mice. We identify new biological targets affected by the mutation, including mammary and eccrine glands. Building on these results, we find that EDAR370A is associated with an increased number of active eccrine glands in the Han Chinese. This interdisciplinary approach yields unique insight into the generation of adaptive variation among modern humans.
journal_name
Celljournal_title
Cellauthors
Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jindoi
10.1016/j.cell.2013.01.016subject
Has Abstractpub_date
2013-02-14 00:00:00pages
691-702issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(13)00067-6journal_volume
152pub_type
杂志文章相关文献
CELL文献大全abstract::The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00084-2
更新日期:2000-09-01 00:00:00
abstract::We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00566-x
更新日期:2003-08-08 00:00:00
abstract::Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.04.007
更新日期:2010-04-30 00:00:00
abstract::We have examined the molecular basis of the response of individuals of D. melanogaster to artificial selection for high and low abdominal bristles. By monitoring the fate of particular rDNA spacer length variants associated with individually isolated X and Y chromosomes, we show that flies from the low bristle number ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90027-2
更新日期:1983-07-01 00:00:00
abstract::Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90073-y
更新日期:1993-02-26 00:00:00
abstract::The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90391-8
更新日期:1980-01-01 00:00:00
abstract::Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.028
更新日期:2014-01-30 00:00:00
abstract::Telomeres are thought to be maintained by the preferential recruitment of telomerase to the shortest telomeres. The extension of the G-rich telomeric strand by telomerase is also believed to be coordinated with the complementary synthesis of the C strand by the conventional replication machinery. However, we show that...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.05.026
更新日期:2009-08-07 00:00:00
abstract::Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.05.036
更新日期:2012-07-20 00:00:00
abstract::Potassium is an essential mineral element for plant growth and development. Although it is known that plants absorb and transport K+ through membrane transporters, it remains unclear how these transporters are regulated. Here we show that the protein kinase CIPK23, encoded by the LKS1 gene, regulates K+ uptake under l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.06.011
更新日期:2006-06-30 00:00:00
abstract::The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infect...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2021.01.007
更新日期:2021-01-12 00:00:00
abstract::Using double-label quantitative immunoelectron microscopy on ultrathin cryosections of rat liver, we have compared the endocytotic pathways of the receptors for asialoglycoprotein (ASGP-R), mannose-6-phosphate ligands (MP-R), and polymeric IgA (IgA-R). All three were found within the Golgi complex, along the entire pl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90315-5
更新日期:1984-05-01 00:00:00
abstract::Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00632-3
更新日期:2002-02-08 00:00:00
abstract::We propose a mechanism for the priming of influenza viral RNA transcription by capped RNAs in which specific 5'-terminal fragments are cleaved from the capped RNAs by a virion-associated endonuclease. These fragments would serve as the actual primers for the initiation of transcription by the initial incorporation by ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90449-9
更新日期:1981-03-01 00:00:00
abstract::The susceptibility to repair of particular base mismatches by the hex system of Streptococcus pneumoniae was examined by comparison of the nucleotide sequence of the wild-type and eight mutant alleles of the malM gene. A detailed restriction map was constructed for pLS70, and the nucleotide sequence was determined for...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90126-x
更新日期:1982-12-01 00:00:00
abstract::Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81588-3
更新日期:1998-08-21 00:00:00
abstract::Posttranslational modifications of histones have been strongly correlated with transcriptional regulation. In this issue of Cell, comprehensively examined the nature of arginine methyltransferases and histone modifications in p53-mediated transcription. ...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cell.2004.05.021
更新日期:2004-06-11 00:00:00
abstract::Vg1 is a TGF beta-related growth factor encoded by a maternal mRNA localized to vegetal blastomeres in Xenopus embryos. Vg1 precursor protein is abundant in vegetal cells, but the processed mature form has not been readily detected and no activity has been demonstrated for the putative Vg1 mature protein. We have engi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)80045-g
更新日期:1993-08-13 00:00:00
abstract::From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.06.023
更新日期:2007-07-27 00:00:00
abstract::Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birt...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.052
更新日期:2014-08-14 00:00:00
abstract::The mouse t haplotypes show defects in spermatogenesis attributed to multiple loci on chromosome 17. We have cloned the gene for an abundant testicular germ cell protein, t complex polypeptide 1, which has a variant form in t haplotypes, TCP-1A. A cDNA clone, pB1.4, which hybridizes to a 19S mRNA that is abundant in h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90839-1
更新日期:1986-03-14 00:00:00
abstract::Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90179-4
更新日期:1983-12-01 00:00:00
abstract::Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.008
更新日期:2017-10-19 00:00:00
abstract::We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90038-9
更新日期:1987-08-14 00:00:00
abstract::Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution requires understan...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.01.027
更新日期:2015-02-12 00:00:00
abstract::Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active site cysteinyl residue, which executes a nucleophilic attack on substrate phosphotyrosyl residues. The high reactivity of the catalytic cysteine also predisposes...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.07.020
更新日期:2011-09-02 00:00:00
abstract::Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.01.007
更新日期:2020-02-20 00:00:00
abstract::The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.07.017
更新日期:2017-07-27 00:00:00
abstract::Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81705-5
更新日期:1998-12-11 00:00:00
abstract::In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2005.05.018
更新日期:2005-06-03 00:00:00