The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

Abstract:

:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine residues are conserved. The putative Drosophila protein has an extra sequence of 85 amino acids, encoded on an additional exon. Dint-1 is expressed throughout development, but transcripts are barely detectable in adult flies. Hybridization in situ to embryos reveals a segmented pattern of expression. We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication.

journal_name

Cell

journal_title

Cell

authors

Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R

doi

10.1016/0092-8674(87)90038-9

subject

Has Abstract

pub_date

1987-08-14 00:00:00

pages

649-57

issue

4

eissn

0092-8674

issn

1097-4172

pii

0092-8674(87)90038-9

journal_volume

50

pub_type

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