Abstract:
:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine residues are conserved. The putative Drosophila protein has an extra sequence of 85 amino acids, encoded on an additional exon. Dint-1 is expressed throughout development, but transcripts are barely detectable in adult flies. Hybridization in situ to embryos reveals a segmented pattern of expression. We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication.
journal_name
Celljournal_title
Cellauthors
Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse Rdoi
10.1016/0092-8674(87)90038-9subject
Has Abstractpub_date
1987-08-14 00:00:00pages
649-57issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(87)90038-9journal_volume
50pub_type
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