Abstract：
:Potassium is an essential mineral element for plant growth and development. Although it is known that plants absorb and transport K+ through membrane transporters, it remains unclear how these transporters are regulated. Here we show that the protein kinase CIPK23, encoded by the LKS1 gene, regulates K+ uptake under low-K+ conditions. Lesion of LKS1 significantly reduced K+ uptake and caused leaf chlorosis and growth inhibition, whereas overexpression of LKS1 significantly enhanced K+ uptake and tolerance to low K+. We demonstrate that CIPK23 directly phosphorylates the K+ transporter AKT1 and further find that CIPK23 is activated by the binding of two calcineurin B-like proteins, CBL1 and CBL9. We propose a model in which the CBL1/9-CIPK23 pathway ensures activation of AKT1 and enhanced K+ uptake under low-K+ conditions.
journal_name
Celljournal_title
Cellauthors
Xu J,Li HD,Chen LQ,Wang Y,Liu LL,He L,Wu WHdoi
10.1016/j.cell.2006.06.011subject
Has Abstractpub_date
2006-06-30 00:00:00pages
1347-60issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(06)00769-0journal_volume
125pub_type
杂志文章相关文献
CELL文献大全abstract：:Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.08.038
更新日期：2009-10-30 00:00:00
abstract：:Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We id...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.08.029
更新日期：2005-09-23 00:00:00
abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90073-9
更新日期：1983-03-01 00:00:00
abstract：:Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81742-0
更新日期：1998-09-18 00:00:00
abstract：:Neurons make networks of intercellular connections. Many other cells also send out long cellular extensions and "touch" other cells far away. The extensions are intriguing, but what do they do? Possible rationales for this cell behavior include: (1) forming precise binary connections with the possibility of forming mo...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(03)00156-9
更新日期：2003-03-07 00:00:00
abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.11.004
更新日期：2008-11-28 00:00:00
abstract：:The origin of a low molecular weight virus-associated RNA (VA-RNA) was mapped by hybridization of VA-RNA to specific fragments of adenovirus type 2 DNA, obtained after cleavage with three different restriction endonucleases. VA-RNA was found to hybridize exculsively to the l-strand [strand with low buoyant density in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90066-5
更新日期：1975-09-01 00:00:00
abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.020
更新日期：2011-09-02 00:00:00
abstract：:Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (JNK) and Sterol Reg...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.019
更新日期：2015-01-15 00:00:00
abstract：:Embryonal carcinoma cells derived from murine teratocarcinomas are able to differentiate into the same variety of tissue types as early embryonic cells. Because embryonal carcinoma cells resemble those of the embryo at a stage before X chromosome inactivation has occurred in females embryonal carcinoma cells containin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90052-0
更新日期：1976-09-01 00:00:00
abstract：:Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define differences across all hematopoietic cells from syngeneic mouse tumors during unrestrained ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.030
更新日期：2018-11-01 00:00:00
abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90060-8
更新日期：1995-07-14 00:00:00
abstract：:Phosphoinositide 3 kinase (PI3K) is a key signaling enzyme implicated in receptor-stimulated mitogenesis, oxidative bursting in neutrophils, membrane ruffling, and glucose uptake. A PI3K has already been purified, cloned, and shown to be regulated by receptors that act via tyrosine kinase-dependent regulatory mechanis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90237-2
更新日期：1994-04-08 00:00:00
abstract：:Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2014.04.025
更新日期：2014-05-08 00:00:00
abstract：:The chromosomal distributions of five families of mouse r-protein genes (S16, L18, L19, L30 and L32/33) were studied by Southern blot analysis of DNa from a panel of mouse-hamster hybrid cells containing various complements of mouse chromosomes. Our results indicated that members of a particular family are often locat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90320-2
更新日期：1981-05-01 00:00:00
abstract：:Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.02.011
更新日期：2017-03-09 00:00:00
abstract：:Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.12.014
更新日期：2019-01-24 00:00:00
abstract：:The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.06.003
更新日期：2010-07-23 00:00:00
abstract：:cDNA clones of the Drosophila epidermal growth factor receptor homolog (DER) gene were isolated and sequenced. The deduced amino acid sequence shows a similar degree of homology to the human epidermal growth factor receptor and to the rat and human neu proteins; the most striking difference is the addition of a third ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90709-9
更新日期：1986-09-26 00:00:00
abstract：:Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.05.071
更新日期：2016-07-14 00:00:00
abstract：:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90038-9
更新日期：1987-08-14 00:00:00
abstract：:Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond inde...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.05.009
更新日期：2019-05-30 00:00:00
abstract：:Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90616-7
更新日期：1991-07-26 00:00:00
abstract：:As the second dimension to the genome, the epigenome contains key information specific to every type of cells. Thousands of human epigenome maps have been produced in recent years thanks to rapid development of high throughput epigenome mapping technologies. In this review, we discuss the current epigenome mapping too...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.011
更新日期：2013-09-26 00:00:00
abstract：:Metagenomics seeks to characterize the composition of microbial communities, their operations, and their dynamically coevolving relationships with the habitats they occupy without having to culture community members. Uniting metagenomics with analyses of the products of microbial community metabolism (metabolomics) wi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.08.025
更新日期：2008-09-05 00:00:00
abstract：:In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.12.019
更新日期：2009-12-24 00:00:00
abstract：:Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin,...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.05.034
更新日期：2016-06-30 00:00:00
abstract：:Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.03.006
更新日期：2011-03-18 00:00:00
abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80547-4
更新日期：1999-02-05 00:00:00
abstract：:Hybrid transducing phages were constructed in vitro that carry the galK gene fused to each of three ribosomal promoters: the promotor for an rRNA operon (rrnE); the promoter for the spec r protein operon and the promotor for the alpha r protein operon. We also constructed hybrid transducing phages that carry the IacZ ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90185-9
更新日期：1981-09-01 00:00:00
