High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.

abstract：:For the faithful initiation of transcription of exogenously added fibroin gene, a crude cellular extract was prepared from the posterior silk glands where fibroin gene is specifically transcribed. The faithful initiation was demonstrated by the assay with use of truncated fibroin gene templates and confirmed by nuclea...

journal_title：Cell

authors： Tsuda M,Suzuki Y

更新日期：1981-11-01 00:00:00

abstract：:Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we f...

journal_title：Cell

authors： Amaya E,Musci TJ,Kirschner MW

更新日期：1991-07-26 00:00:00

abstract：:MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation. ...

journal_title：Cell

authors： Beitzinger M,Meister G

更新日期：2010-03-05 00:00:00

abstract：:Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change the...

journal_title：Cell

authors： Parks S,Wieschaus E

更新日期：1991-01-25 00:00:00

abstract：:We studied the chromatin structure and methylation of ribosomal RNA genes (rDNA) in hybrids between Xenopus laevis and Xenopus borealis. S1-nuclease protection experiments showed that 97%-98% of the rRNA precursor in hybrid tadpoles was of the X. laevis type. Preferential expression of the laevis rDNA was correlated w...

journal_title：Cell

authors： Macleod D,Bird A

更新日期：1982-05-01 00:00:00

abstract：:The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid ini...

journal_title：Cell

authors： Fisher JM,Sossin W,Newcomb R,Scheller RH

更新日期：1988-09-09 00:00:00

abstract：:In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are ...

journal_title：Cell

authors： Grubaugh ND,Hanage WP,Rasmussen AL

更新日期：2020-08-20 00:00:00

abstract：:The removal of apoptotic cells by phagocytic neighbors is essential for metazoan development but remains poorly characterized. Here we report the discovery of a Drosophila phagocytosis receptor, Six-microns-under (SIMU), which is expressed in highly phagocytic cell types during development and required for efficient a...

journal_title：Cell

authors： Kurant E,Axelrod S,Leaman D,Gaul U

更新日期：2008-05-02 00:00:00

abstract：:Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...

journal_title：Cell

authors： Tang JC,Szikra T,Kozorovitskiy Y,Teixiera M,Sabatini BL,Roska B,Cepko CL

更新日期：2013-08-15 00:00:00

abstract：:The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...

journal_title：Cell

authors： Liu X,Xu X,Hilger D,Aschauer P,Tiemann JKS,Du Y,Liu H,Hirata K,Sun X,Guixà-González R,Mathiesen JM,Hildebrand PW,Kobilka BK

更新日期：2019-05-16 00:00:00

abstract：:Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation. ...

journal_title：Cell

authors： Green R,Lorsch JR

更新日期：2002-09-20 00:00:00

abstract：:Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads")...

journal_title：Cell

authors： Ilardo MA,Moltke I,Korneliussen TS,Cheng J,Stern AJ,Racimo F,de Barros Damgaard P,Sikora M,Seguin-Orlando A,Rasmussen S,van den Munckhof ICL,Ter Horst R,Joosten LAB,Netea MG,Salingkat S,Nielsen R,Willerslev E

更新日期：2018-04-19 00:00:00

abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...

journal_title：Cell

authors： Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

更新日期：1998-05-29 00:00:00

abstract：:Repression of the yeast silent mating type loci requires cis-acting sequences located over 1 kb from the regulated promoters. One of these sites, a "silencer," exhibits enhancer-like distance- and orientation-independence. The silencer demonstrates both autonomous replication sequence (ARS) activity and a centromere-l...

journal_title：Cell

authors： Brand AH,Micklem G,Nasmyth K

更新日期：1987-12-04 00:00:00

abstract：:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...

journal_title：Cell

authors： Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

更新日期：2011-10-14 00:00:00

abstract：:Dopamine neurons promote learning by processing recent changes in reward values, such that reward may be maximized. However, such a flexible signal is not suitable for habitual behaviors that are sustained regardless of recent changes in reward outcome. We discovered a type of dopamine neuron in the monkey substantia ...

journal_title：Cell

authors： Kim HF,Ghazizadeh A,Hikosaka O

更新日期：2015-11-19 00:00:00

abstract：:The major site of in vivo transcriptional initiation for both heavy and light strands of human mitochondrial DNA is the displacement-loop region. Transcripts synthesized in vitro by human mitochondrial RNA polymerase were mapped to the nucleotide level and have identical 5' end map positions to those reported for in v...

journal_title：Cell

authors： Chang DD,Clayton DA

更新日期：1984-03-01 00:00:00

abstract：:The unfolded protein response (UPR) regulates gene expression in response to stress in the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using DNA microarrays. Rather than regulating only ER-resident chaperones and phospholipid biosynthesis, as anticipated from earlier work, the UPR af...

journal_title：Cell

authors： Travers KJ,Patil CK,Wodicka L,Lockhart DJ,Weissman JS,Walter P

更新日期：2000-04-28 00:00:00

abstract：:The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...

journal_title：Cell

authors： McKnight GS,Hager L,Palmiter RD

更新日期：1980-11-01 00:00:00

abstract：:Accumulating evidence for nascent-peptide-mediated regulation of translation suggests that all nascent peptides do not necessarily interact with the ribosome in a similar manner. Recent studies have helped to elucidate the exit route of the nascent chain and its interactions with the ribosome. ...

journal_title：Cell

authors： Tenson T,Ehrenberg M

更新日期：2002-03-08 00:00:00

abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...

journal_title：Cell

authors： Zhang YZ,Holmes EC

更新日期：2020-04-16 00:00:00

abstract：:The "protective protein" is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder galactosialidosis. We have isolated the cDNA encoding human "protective protein". The clone recognizes a 2 kb mRNA in normal cells that is not evident in f...

journal_title：Cell

authors： Galjart NJ,Gillemans N,Harris A,van der Horst GT,Verheijen FW,Galjaard H,d'Azzo A

更新日期：1988-09-09 00:00:00

abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...

journal_title：Cell

authors： Nishimura I,Yang Y,Lu B

更新日期：2004-03-05 00:00:00

abstract：:Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation....

journal_title：Cell

authors： Orkin SH,Zon LI

更新日期：2008-02-22 00:00:00

abstract：:We report here the identification of thyroid hormone response elements (TREs) that consist of a direct repeat, not a palindrome, of the half-sites. Unlike palindromic TREs, direct repeat TREs do not confer a retinoic acid response. The tandem TRE can be converted into a retinoic acid response element by increasing the...

journal_title：Cell

authors： Umesono K,Murakami KK,Thompson CC,Evans RM

更新日期：1991-06-28 00:00:00

abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...

journal_title：Cell

authors： de Bruin RA,McDonald WH,Kalashnikova TI,Yates J 3rd,Wittenberg C

更新日期：2004-06-25 00:00:00

abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...

journal_title：Cell

authors： Clarkson SG,Kurer V,Smith HO

更新日期：1978-07-01 00:00:00

abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...

journal_title：Cell

authors： Aguzzi A,Polymenidou M

更新日期：2004-01-23 00:00:00

abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...

journal_title：Cell

authors： Blackwell TK,Walker AK

更新日期：2008-10-03 00:00:00

abstract：:Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here. ...

journal_title：Cell

authors： Borst P

更新日期：2002-04-05 00:00:00