Abstract：
:The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid initial proteolytic cleavage of the prohormone followed by sorting at the trans Golgi. Egg-laying hormone (ELH) immunoreactivity is localized to the cell body and processes, while bag cell peptide (BCP) immunoreactivity is greater in the cell body. Steady state levels of the amino-terminal set of peptides including the BCPs are 3- to 8-fold lower than the carboxy-terminal cleavage products, such as ELH. Thus, intracellular packaging and routing of the peptides cleaved from a single prohormone regulate their localization and levels in these neurons.
journal_name
Celljournal_title
Cellauthors
Fisher JM,Sossin W,Newcomb R,Scheller RHdoi
10.1016/s0092-8674(88)91131-2subject
Has Abstractpub_date
1988-09-09 00:00:00pages
813-22issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(88)91131-2journal_volume
54pub_type
杂志文章相关文献
CELL文献大全abstract：:Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process catalyzed by a specialized membrane-fusion protein expressed on their surface. This review focuses on recent structural studies of viral fusion proteins with an emphasis on their metastable prefusion form and on interactions wi...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2018.02.054
更新日期：2018-03-08 00:00:00
abstract：:The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.10.021
更新日期：2016-11-03 00:00:00
abstract：:In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90150-6
更新日期：1975-04-01 00:00:00
abstract：:The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex. Direct interaction of Vpr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.011
更新日期：2014-01-16 00:00:00
abstract：:We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90050-3
更新日期：1979-10-01 00:00:00
abstract：:The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injectio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90192-4
更新日期：1988-07-29 00:00:00
abstract：:The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.10.028
更新日期：2017-11-02 00:00:00
abstract：:Transposon mutagenesis and complementation analysis of the photosynthesis genes in Rhodopseudomonas capsulata is presented utilizing Tn5.7 mutagenized R-primes. The R-prime pRPS404 contains many of the genes necessary for the differentiation of the photosynthetic apparatus. Utilizing homologous recombination, 30 indep...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90428-8
更新日期：1984-07-01 00:00:00
abstract：:Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90073-y
更新日期：1993-02-26 00:00:00
abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.049
更新日期：2019-01-10 00:00:00
abstract：:Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system. We have fractionated mitotic Xenopus egg extracts to identify components required for this process. We find that UBC4 and at least one other ubiquitin-conjugating enzyme can support cyclin B ubiquitination. The mitotic specifici...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90338-0
更新日期：1995-04-21 00:00:00
abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81447-6
更新日期：1998-05-29 00:00:00
abstract：:The eye lens contains a structural protein (alpha-crystallin), composed of two homologous primary gene products, alpha A2 and alpha B2. In certain rodents, there is another minor alpha-crystallin polypeptide, alpha Ains, which is identical to alpha A2 except for a 22 amino acid insert between residues 63 and 64 of the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90056-9
更新日期：1983-03-01 00:00:00
abstract：:As visualized by electron microscopy, RecA protein binds in a highly cooperative manner to single-stranded fd DNA in solutions of 0.01 M Tris (pH 7.5). The resulting nucleoprotein filament loops are 1.25 micrometers in length, have a fiber diameter of 12 nm and show an indication of a 4.5 nm repeat along the axis of t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90055-1
更新日期：1982-04-01 00:00:00
abstract：:Sharply delineated domains of cell types arise in developing tissues under instruction of inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. The translation of a morphogen gradient into discrete spatial domains relies on precise signal responses at stable cell positio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.03.023
更新日期：2013-04-25 00:00:00
abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.11.043
更新日期：2018-01-25 00:00:00
abstract：:To determine the special feature of ribosomal RNA promoters that might account for the highly efficient and regulated synthesis of rRNA in E. coli, we have analyzed the beginnings of two ribosomal RNA operons, rrnD and rrnX. DNA sequences for 425 bp preceding those specifying mature 16s rRNA are reported. In vitro tra...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90310-6
更新日期：1979-05-01 00:00:00
abstract：:During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing. Using female mouse embryonic stem cells, we initiate XCI by inducing Xist and then...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.11.041
更新日期：2019-01-10 00:00:00
abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00976-0
更新日期：2003-12-12 00:00:00
abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90125-4
更新日期：1985-09-01 00:00:00
abstract：:The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.09.025
更新日期：2005-10-21 00:00:00
abstract：:In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.07.045
更新日期：2010-09-03 00:00:00
abstract：:The Escherichia coli relBE operon encodes a toxin-antitoxin pair, RelE-RelB. RelB can reverse inhibition of protein synthesis by RelE in vivo. We have found that although RelE does not degrade free RNA, it cleaves mRNA in the ribosomal A site with high codon specificity. Among stop codons UAG is cleaved with fast, UAA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01248-5
更新日期：2003-01-10 00:00:00
abstract：:Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2017.01.017
更新日期：2017-02-09 00:00:00
abstract：:A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2005.01.029
更新日期：2005-02-25 00:00:00
abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.12.028
更新日期：2012-02-17 00:00:00
abstract：:The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis. Bax activity is counteracted by prosurvival Bcl-2 proteins, but how they inhibit Bax remains controversial because they neither colocalize nor form s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.02.034
更新日期：2011-04-01 00:00:00
abstract：:The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antivira...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.07.018
更新日期：2011-08-05 00:00:00
abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80547-4
更新日期：1999-02-05 00:00:00
abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90469-f
更新日期：1991-05-03 00:00:00
