A prion-like trigger of antiviral signaling.

abstract：:ROR-γt+ regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. find that the set-point for ROR-γt+ Tregs is non-genetically maternally inherited during a critical time window...

journal_title：Cell

authors： Zimmermann J,Macpherson AJ

更新日期：2020-06-11 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Cells from NBS patients are hypersensitive to ionizing radiation with cytogenetic features indistinguishable from ataxia telangiect...

journal_title：Cell

authors： Varon R,Vissinga C,Platzer M,Cerosaletti KM,Chrzanowska KH,Saar K,Beckmann G,Seemanová E,Cooper PR,Nowak NJ,Stumm M,Weemaes CM,Gatti RA,Wilson RK,Digweed M,Rosenthal A,Sperling K,Concannon P,Reis A

更新日期：1998-05-01 00:00:00

abstract：:RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome...

journal_title：Cell

authors： Hafner M,Landthaler M,Burger L,Khorshid M,Hausser J,Berninger P,Rothballer A,Ascano M Jr,Jungkamp AC,Munschauer M,Ulrich A,Wardle GS,Dewell S,Zavolan M,Tuschl T

更新日期：2010-04-02 00:00:00

abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...

journal_title：Cell

authors： Ohtsubo K,Takamatsu S,Minowa MT,Yoshida A,Takeuchi M,Marth JD

更新日期：2005-12-29 00:00:00

abstract：:Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...

journal_title：Cell

authors： Schweisguth F,Posakony JW

更新日期：1992-06-26 00:00:00

abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...

journal_title：Cell

authors： Bensaad K,Tsuruta A,Selak MA,Vidal MN,Nakano K,Bartrons R,Gottlieb E,Vousden KH

更新日期：2006-07-14 00:00:00

abstract：:Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significan...

journal_title：Cell

authors： Demireva EY,Shapiro LS,Jessell TM,Zampieri N

更新日期：2011-10-28 00:00:00

abstract：:Different species of fruit flies share habitats but are believed to mate with each other only rarely. In this issue, Fan et al. show that interspecies mating is inhibited by the taste receptor Gr32a (Gustatory receptor 32a) and a neural circuit in which it functions. ...

journal_title：Cell

authors： Koh TW,Carlson JR

更新日期：2013-07-03 00:00:00

abstract：:A study in this issue of Cell illustrates the power of applying genomic approaches with model systems to characterize the biological activity of small molecules and to identify their cellular targets, which can clarify the mode of action of human therapeutics. ...

journal_title：Cell

authors： Hughes T,Andrews B,Boone C

更新日期：2004-01-09 00:00:00

abstract：:There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...

journal_title：Cell

authors： Fischbach MA

更新日期：2018-08-09 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the extracellular factor(s) that initiate neuronal polarity ...

journal_title：Cell

authors： Yi JJ,Barnes AP,Hand R,Polleux F,Ehlers MD

更新日期：2010-07-09 00:00:00

abstract：:S. cerevisiae strains containing RAS2val19, a RAS2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1. Yeast strains carrying the IAC mutation have elevated leve...

journal_title：Cell

authors： Toda T,Uno I,Ishikawa T,Powers S,Kataoka T,Broek D,Cameron S,Broach J,Matsumoto K,Wigler M

更新日期：1985-01-01 00:00:00

abstract：:During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...

journal_title：Cell

authors： Baker CC,Herisse J,Courtois G,Galibert F,Ziff E

更新日期：1979-10-01 00:00:00

abstract：:A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell...

journal_title：Cell

authors： Jaillais Y,Santambrogio M,Rozier F,Fobis-Loisy I,Miège C,Gaude T

更新日期：2007-09-21 00:00:00

abstract：:Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan ribos...

journal_title：Cell

authors： Dann CE 3rd,Wakeman CA,Sieling CL,Baker SC,Irnov I,Winkler WC

更新日期：2007-09-07 00:00:00

abstract：:Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying...

journal_title：Cell

authors： Dale JK,Vesque C,Lints TJ,Sampath TK,Furley A,Dodd J,Placzek M

更新日期：1997-07-25 00:00:00

abstract：:Histone acetyltransferases (HATs) and histone deacetylases (HDACs) conduct many critical functions through nonhistone substrates in metazoans, but only chromatin-associated nonhistone substrates are known in Saccharomyces cerevisiae. Using yeast proteome microarrays, we identified and validated many nonchromatin subst...

journal_title：Cell

authors： Lin YY,Lu JY,Zhang J,Walter W,Dang W,Wan J,Tao SC,Qian J,Zhao Y,Boeke JD,Berger SL,Zhu H

更新日期：2009-03-20 00:00:00

abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...

journal_title：Cell

authors： Fisher PR,Smith E,Williams KL

更新日期：1981-03-01 00:00:00

abstract：:The S. pombe nuc2+ gene is required for mitotic chromosome disjunction. Its mutation arrests mitosis at the metaphase. The gene product is present in the nuclear scaffold-like fraction. The nuc2+ protein contains a domain, separated from ten 34 amino acid repeat segments, that is capable of binding AT-rich DNA in vitr...

journal_title：Cell

authors： Hirano T,Kinoshita N,Morikawa K,Yanagida M

更新日期：1990-01-26 00:00:00

abstract：:Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kilobases. HOX ncRNAs ...

journal_title：Cell

authors： Rinn JL,Kertesz M,Wang JK,Squazzo SL,Xu X,Brugmann SA,Goodnough LH,Helms JA,Farnham PJ,Segal E,Chang HY

更新日期：2007-06-29 00:00:00

abstract：:We have identified a nuclear pathway that rapidly degrades unspliced pre-mRNAs in yeast. This involves 3'-->5' degradation by the exosome complex and 5'-->3' degradation by the exonuclease Rat1p. 3'-->5' degradation is normally the major pathway and is regulated in response to carbon source. Inhibition of pre-mRNA deg...

journal_title：Cell

authors： Bousquet-Antonelli C,Presutti C,Tollervey D

更新日期：2000-09-15 00:00:00

abstract：:We present the first isolation of the terminal DNA of an intact Drosophila telomere. It differs from those isolated from other eukaryotes by the lack of short tandem repeats at the terminus. The terminal 14.5 kb is composed of four tandem elements derived from two families of non-long terminal repeat retrotransposons ...

journal_title：Cell

authors： Levis RW,Ganesan R,Houtchens K,Tolar LA,Sheen FM

更新日期：1993-12-17 00:00:00

abstract：:Clones containing five non-adult beta-globin genes were isolated from a library of BALB/c DNA. Together, the newly cloned regions comprise a contiguous block of 32 kb of the mouse genome. Restriction mapping of genomic DNA established the physical linkage of these non-adult genes to the two adult beta-globin genes as ...

journal_title：Cell

authors： Jahn CL,Hutchison CA 3rd,Phillips SJ,Weaver S,Haigwood NL,Voliva CF,Edgell MH

更新日期：1980-08-01 00:00:00

abstract：:Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...

journal_title：Cell

authors： Joyce MG,Wheatley AK,Thomas PV,Chuang GY,Soto C,Bailer RT,Druz A,Georgiev IS,Gillespie RA,Kanekiyo M,Kong WP,Leung K,Narpala SN,Prabhakaran MS,Yang ES,Zhang B,Zhang Y,Asokan M,Boyington JC,Bylund T,Darko S,Lees

更新日期：2016-07-28 00:00:00

abstract：:Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of s...

journal_title：Cell

authors： César-Razquin A,Snijder B,Frappier-Brinton T,Isserlin R,Gyimesi G,Bai X,Reithmeier RA,Hepworth D,Hediger MA,Edwards AM,Superti-Furga G

更新日期：2015-07-30 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kin...

journal_title：Cell

authors： Soppet D,Escandon E,Maragos J,Middlemas DS,Reid SW,Blair J,Burton LE,Stanton BR,Kaplan DR,Hunter T,Nikolics K,Parada LF

更新日期：1991-05-31 00:00:00

abstract：:Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...

journal_title：Cell

authors： Sanders SL,Whitfield KM,Vogel JP,Rose MD,Schekman RW

更新日期：1992-04-17 00:00:00

abstract：:Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...

journal_title：Cell

authors： Epstein PN,Overbeek PA,Means AR

更新日期：1989-09-22 00:00:00

abstract：:Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls a...

journal_title：Cell

authors： Lieb JD,Clarke ND

更新日期：2005-12-29 00:00:00