DNA sequence organization of the beta-globin complex in the BALB/c mouse.


:Clones containing five non-adult beta-globin genes were isolated from a library of BALB/c DNA. Together, the newly cloned regions comprise a contiguous block of 32 kb of the mouse genome. Restriction mapping of genomic DNA established the physical linkage of these non-adult genes to the two adult beta-globin genes as well as the two adult genes to each other. Thus this entire BALB/c beta-globin complex consists of seven linked genes, all with the same transcriptional orientation, arrayed over 70 kb of DNA. The order of these genes is: 5'-epsilon y3-beta h0-beta h1-beta h2-beta h3-beta major-beta minor-3' Portions of each of the five newly identified genes have been sequenced. Only one, epsilon y3, encodes a previously described globin. beta h0 and beta h1, which are closely related, differ significantly from both adult and embryonic globins. The beta h2 sequence is more closely related to the adult genes than to the other non-adult genes. However, it is the sequence least homologous to both of these classes. The 5' half of the beta h3 gene (preceding codon 75) has an aberrant structure. The rest of this sequence is intact, resembling an adult beta-globin gene except for an inserted base at cocon 90, resulting in a frameshift. Consequently, the beta h3 sequence cannot be translated to produce a normal beta-globin.






Jahn CL,Hutchison CA 3rd,Phillips SJ,Weaver S,Haigwood NL,Voliva CF,Edgell MH




Has Abstract


1980-08-01 00:00:00
















  • Biochemical and genetic characterization of a competence pheromone from B. subtilis.

    abstract::We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...


    pub_type: 杂志文章


    authors: Magnuson R,Solomon J,Grossman AD

    更新日期:1994-04-22 00:00:00

  • 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

    abstract::All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental app...


    pub_type: 杂志文章


    authors: Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

    更新日期:1992-01-24 00:00:00

  • Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.

    abstract::From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...


    pub_type: 杂志文章


    authors: Rheinwald JG,Green H

    更新日期:1975-11-01 00:00:00

  • The primary sequence of rabbit alpha-globin mRNA.

    abstract::The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...


    pub_type: 杂志文章


    authors: Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

    更新日期:1978-09-01 00:00:00

  • Interspecies sex and taste.

    abstract::Different species of fruit flies share habitats but are believed to mate with each other only rarely. In this issue, Fan et al. show that interspecies mating is inhibited by the taste receptor Gr32a (Gustatory receptor 32a) and a neural circuit in which it functions. ...


    pub_type: 评论,杂志文章


    authors: Koh TW,Carlson JR

    更新日期:2013-07-03 00:00:00

  • Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles.

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    pub_type: 杂志文章


    authors: Mayer A,Wickner W,Haas A

    更新日期:1996-04-05 00:00:00

  • A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences.

    abstract::The BALC/c mouse has two nonallelic beta-globin genes that appear to reside on two different Eco R1 fragments of genomic DNA. We have already cloned one of these fragments and shown that the gene encoded within it is interrupted by at least one large intervening sequence of DNA. We have now cloned and characterized th...


    pub_type: 杂志文章


    authors: Tiemeier DC,Tilghman SM,Polsky FI,Seidman JG,Leder A,Edgell MH,Leder P

    更新日期:1978-06-01 00:00:00

  • Growth hormone and the adipose conversion of 3T3 cells.

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    pub_type: 杂志文章


    authors: Morikawa M,Nixon T,Green H

    更新日期:1982-07-01 00:00:00

  • Conformational changes in a replication origin induced by an initiator protein.

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    pub_type: 杂志文章


    authors: Mukherjee S,Patel I,Bastia D

    更新日期:1985-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Berek C,Berger A,Apel M

    更新日期:1991-12-20 00:00:00

  • Hybrid transfer RNA genes in phage T4.

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    pub_type: 杂志文章


    authors: McClain WH,Foss K

    更新日期:1984-08-01 00:00:00

  • MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids.

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    pub_type: 杂志文章


    authors: Woloshin P,Song K,Degnin C,Killary AM,Goldhamer DJ,Sassoon D,Thayer MJ

    更新日期:1995-08-25 00:00:00

  • Characterization of the bovine papilloma virus plasmid maintenance sequences.

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    pub_type: 杂志文章


    authors: Lusky M,Botchan MR

    更新日期:1984-02-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Rothman JE

    更新日期:1989-11-17 00:00:00

  • Metabolic Control of Longevity.

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    pub_type: 杂志文章,评审


    authors: López-Otín C,Galluzzi L,Freije JMP,Madeo F,Kroemer G

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  • Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.

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    pub_type: 杂志文章


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  • Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.

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  • Hallmarks of cancer: the next generation.

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    pub_type: 杂志文章,评审


    authors: Hanahan D,Weinberg RA

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    pub_type: 杂志文章


    authors: Takeya T,Hanafusa H

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    pub_type: 杂志文章


    authors: Correa-Bordes J,Nurse P

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    pub_type: 杂志文章


    authors: Fisher PR,Smith E,Williams KL

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    authors: Ginsberg M,James D,Ding BS,Nolan D,Geng F,Butler JM,Schachterle W,Pulijaal VR,Mathew S,Chasen ST,Xiang J,Rosenwaks Z,Shido K,Elemento O,Rabbany SY,Rafii S

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    pub_type: 杂志文章


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    pub_type: 评论,杂志文章


    authors: Pirrotta V

    更新日期:2009-03-20 00:00:00

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    pub_type: 杂志文章


    authors: McCarty DR,Hattori T,Carson CB,Vasil V,Lazar M,Vasil IK

    更新日期:1991-09-06 00:00:00

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    pub_type: 杂志文章


    authors: Mao Y,Chen J,Maynard JA,Zhang B,Quiocho FA

    更新日期:2001-02-09 00:00:00