Abstract:
:It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human protein, hRap1, that is an ortholog of the yeast telomeric protein, scRap1p. hRap1 has three conserved sequence motifs in common with scRap1, is located at telomeres, and affects telomere length. However, while scRap1 binds telomeric DNA directly, hRap1 is recruited to telomeres by TRF2. Extending the comparison of telomeric proteins to fission yeast, we identify S. pombe Taz1 as a TRF ortholog, indicating that TRFs are conserved at eukaryotic telomeres. The data suggest that ancestral telomeres, like those of vertebrates, contained a TRF-like protein as well as Rap1. We propose that budding yeast preserved Rap1 at telomeres but lost the TRF component, possibly concomitant with a change in the telomeric repeat sequence.
journal_name
Celljournal_title
Cellauthors
Li B,Oestreich S,de Lange Tdoi
10.1016/s0092-8674(00)80858-2subject
Has Abstractpub_date
2000-05-26 00:00:00pages
471-83issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80858-2journal_volume
101pub_type
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