Abstract：
:The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS). XP is a human autosomal recessive disease characterized by extreme sensitivity to ultraviolet irradiation and marked susceptibility to skin cancer. In addition, XP and CS patients often exhibit a variety of defects, ranging from central nervous system disorders to hypogonadism. Phenotypes of haywire mutants mimic some of the effects of XP. Many haywire alleles are recessive lethal, viable alleles cause ultraviolet sensitivity, and files expressing marginal levels of haywire display motor defects and reduced life span. Progeny of females carrying a maternal effect allele show central nervous system defects.
journal_name
Celljournal_title
Cellauthors
Mounkes LC,Jones RS,Liang BC,Gelbart W,Fuller MTdoi
10.1016/0092-8674(92)90389-tsubject
Has Abstractpub_date
1992-12-11 00:00:00pages
925-37issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(92)90389-Tjournal_volume
71pub_type
杂志文章相关文献
CELL文献大全abstract：:Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)00711-0
更新日期：2002-04-05 00:00:00
abstract：:Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80729-1
更新日期：1999-04-16 00:00:00
abstract：:Trypanosoma brucei expresses variant surface glycoprotein (VSG) genes in a strictly monoallelic fashion in its mammalian hosts, but it is unclear how this important virulence mechanism is enforced. Telomere position effect, an epigenetic phenomenon, has been proposed to play a critical role in VSG regulation, yet no t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.01.037
更新日期：2009-04-03 00:00:00
abstract：:Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that co...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.12.036
更新日期：2005-03-11 00:00:00
abstract：:A new type of mutation that affects a discrete step in the process of adsorptive endocytosis has been identified in one of 22 strains of fibroblasts derived from subjects with the clinical phenotype of homozygous familial hypercholesterolemia (FH). In this unique mutant strain (derived from subject J.D.), the cell sur...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90130-6
更新日期：1976-12-01 00:00:00
abstract：:DMC1 is a new meiosis-specific yeast gene. Dmc1 protein is structurally similar to bacterial RecA proteins. dmc1 mutants are defective in reciprocal recombination, accumulate double-strand break (DSB) recombination intermediates, fail to form normal synaptonemal complex (SC), and arrest late in meiotic prophase. dmc1 ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90446-j
更新日期：1992-05-01 00:00:00
abstract：:Genetic and transcriptional maps have been constructed for the mitochondrial genome of the Ascomycete Podospora anserina. These data have been plotted on the restriction maps for Sal I, Xho I, Bam HI, Eco RI, BgI II and Hae III. We have characterized and cloned a new and unique senescent mitochondrial DNA (beta-event ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90167-2
更新日期：1982-06-01 00:00:00
abstract：:The CD4 lymphocyte surface glycoprotein and the lck tyrosine protein kinase p56lck are found as a complex in T lymphocytes. We have defined the domains in both proteins that are responsible for this interaction by coexpressing hybrid and deleted forms of the two proteins in HeLa cells. We have found that the unique 32...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90008-1
更新日期：1989-11-17 00:00:00
abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90324-6
更新日期：1979-08-01 00:00:00
abstract：:A family of novel substrates was designed to enable the efficient accumulation of intermediates in site-specific recombination. Strategically placed nicks allow these "suicide substrates" to initiate the reaction but prevent its completion or reversal. Consequently, it has been possible to determine that lambda site-s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90336-9
更新日期：1987-08-28 00:00:00
abstract：:On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00207-5
更新日期：2000-12-22 00:00:00
abstract：:The loss of expression of particular microRNAs can contribute to tumorigenesis. Kota et al. (2009) now explore in a mouse model a promising new approach for the treatment of liver cancer-re-establishing the expression of an miRNA using a viral vector. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.05.038
更新日期：2009-06-12 00:00:00
abstract：:Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to function in membrane merger. Its presence in the major eukaryotic taxa-animals, plants, and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.01.024
更新日期：2017-02-23 00:00:00
abstract：:Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to malignancy. Here, we use mosaic an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.06.014
更新日期：2011-07-22 00:00:00
abstract：:The physical state of the viral genome in four lines of hamster cells transformed by adenovirus type 12 (Ad12) has been investigated. The four lines of transformed cells originated from hamster cells after infection with Ad12 at multiplicities ranging from 5-350 plaque-forming units per cell. The DNA from transformed ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90144-1
更新日期：1977-01-01 00:00:00
abstract：:Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.05.011
更新日期：2015-05-21 00:00:00
abstract：:As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.12.027
更新日期：2018-02-08 00:00:00
abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01139-x
更新日期：2002-12-13 00:00:00
abstract：:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90353-8
更新日期：1985-04-01 00:00:00
abstract：:During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region dur...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.08.001
更新日期：2019-09-19 00:00:00
abstract：:The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a single-domain antibody fragment ("nanobody") discovered using a synthetic yeast-display...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.12.006
更新日期：2019-01-24 00:00:00
abstract：:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81903-0
更新日期：1997-03-07 00:00:00
abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00863-2
更新日期：2002-08-23 00:00:00
abstract：:Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, but the mechanism of autophagy targeting and its role in natural inf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.06.040
更新日期：2012-08-17 00:00:00
abstract：:Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (L...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.10.001
更新日期：2017-11-30 00:00:00
abstract：:Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mecha...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.03.011
更新日期：2006-03-24 00:00:00
abstract：:The effects of beta-estradiol (estrogen; a minor component of yeast cells) on S. cerevisiae cells in the G0 and G1 phases were examined. Results showed that estrogen stimulated the recovery of growth from G0 arrest induced by nutrient limitation or ts mutation of cdc35 (adenylate cyclase) in the early G1 phase, and in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90136-0
更新日期：1989-05-19 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one in ten people. Patients suffering from severe AD eventually progress to develop asthma and allergic rhinitis, in a process known as the "atopic march." Signaling between epithelial cells and innate immune cells via the cyto...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.08.057
更新日期：2013-10-10 00:00:00
abstract：:It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 phys...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.06.028
更新日期：2014-08-14 00:00:00
abstract：:We have examined the molecular organization of a region of mouse chromosome 17 that allows homologous recombination between wild-type and t haplotype chromosomes across a large inversion. We have used a combination of genetic mapping of restriction fragment length polymorphisms, molecular characterization of cloned re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90078-x
更新日期：1987-03-13 00:00:00
