Abstract:
:Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between cell proliferation and apoptosis. Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that mats and wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila. As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans.
journal_name
Celljournal_title
Cellauthors
Lai ZC,Wei X,Shimizu T,Ramos E,Rohrbaugh M,Nikolaidis N,Ho LL,Li Ydoi
10.1016/j.cell.2004.12.036subject
Has Abstractpub_date
2005-03-11 00:00:00pages
675-85issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00003-6journal_volume
120pub_type
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