Chemical genetics: where genetics and pharmacology meet.

abstract：:Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...

journal_title：Cell

authors： Sun LO,Barres BA

更新日期：2016-05-05 00:00:00

abstract：:Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experim...

journal_title：Cell

authors： Ben-Zvi D,Melton DA

更新日期：2015-03-26 00:00:00

abstract：:To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilii. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous sy...

journal_title：Cell

authors： Denes AS,Jékely G,Steinmetz PR,Raible F,Snyman H,Prud'homme B,Ferrier DE,Balavoine G,Arendt D

更新日期：2007-04-20 00:00:00

abstract：:The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...

journal_title：Cell

authors： Shimamoto Y,Maeda YT,Ishiwata S,Libchaber AJ,Kapoor TM

更新日期：2011-06-24 00:00:00

abstract：:32P-labeled cowpea mosaic virus (CPMV) RNAs were analyzed for their 5' termini by three different fingerprinting standard procedures. These analyses showed unequivocally that CPMV RNAs lack a structure like m7GpppN ... at their 5' termini. In addition, neither mono-, di- or triphosphorylated [(p)(p)pN ....] termini we...

journal_title：Cell

authors： Klootwijk J,Klein I,Zabel P,van Kammen A

更新日期：1977-05-01 00:00:00

abstract：:Spatial organization of cellular proteins plays an important role in establishment of cellular polarity to regulate cell division, differentiation, migration, and organogenesis. Activation of T cells by antigen-presenting cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling s...

journal_title：Cell

authors： Yeh JH,Sidhu SS,Chan AC

更新日期：2008-03-07 00:00:00

abstract：:The majority of the mRNA molecules in HeLa cells contain 1-2 residue(s) of m6Ap and one blocked, methylated 5' terminal "cap" structure. The hnRNA, which is longer than mRNA, contains both m6Ap and caps but 4-6 times as many m6Ap residues per chain. In addition, nuclear molecules contain T2 RNA ase-resistant, methyl-l...

journal_title：Cell

authors： Salditt-Georgieff M,Jelinek W,Darnell JE,Furuichi Y,Morgan M,Shatkin A

更新日期：1976-02-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a lethal human disease characterized by motor neuron dysfunction and muscle deterioration due to depletion of the ubiquitous survival motor neuron (SMN) protein. Drosophila SMN mutants have reduced muscle size and defective locomotion, motor rhythm, and motor neuron neurotransmission. ...

journal_title：Cell

authors： Imlach WL,Beck ES,Choi BJ,Lotti F,Pellizzoni L,McCabe BD

更新日期：2012-10-12 00:00:00

abstract：:Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endot...

journal_title：Cell

authors： Iwasaki A,Medzhitov R

更新日期：2011-09-16 00:00:00

abstract：:The Polycomb group (Pc-G) proteins are responsible for keeping developmental regulators, like homeotic genes, stably and inheritably repressed during Drosophila development. Several similarities to a protein class involved in heterochromatin formation suggest that the Pc-G exerts its function at the higher order chrom...

journal_title：Cell

authors： Orlando V,Paro R

更新日期：1993-12-17 00:00:00

abstract：:It has been proposed that the initiator protein RepA is rate limiting for mini-P1 plasmid replication, and that the role of the plasmid copy number control locus is to sequester the initiator and thus reduce replication. This proposal appears inconsistent with the observation that RepA is autoregulated, since the prot...

journal_title：Cell

authors： Chattoraj DK,Mason RJ,Wickner SH

更新日期：1988-02-26 00:00:00

abstract：:We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transc...

journal_title：Cell

authors： Sonigo P,Alizon M,Staskus K,Klatzmann D,Cole S,Danos O,Retzel E,Tiollais P,Haase A,Wain-Hobson S

更新日期：1985-08-01 00:00:00

abstract：:The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...

journal_title：Cell

authors： Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

更新日期：2009-08-21 00:00:00

abstract：:Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy. However, despite the identification of 12 BBS genes, the molecular basis of BBS remains elusive. Here we identify a complex composed of seven h...

journal_title：Cell

authors： Nachury MV,Loktev AV,Zhang Q,Westlake CJ,Peränen J,Merdes A,Slusarski DC,Scheller RH,Bazan JF,Sheffield VC,Jackson PK

更新日期：2007-06-15 00:00:00

abstract：:Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A ...

journal_title：Cell

authors： Tobin DM,Vary JC Jr,Ray JP,Walsh GS,Dunstan SJ,Bang ND,Hagge DA,Khadge S,King MC,Hawn TR,Moens CB,Ramakrishnan L

更新日期：2010-03-05 00:00:00

abstract：:The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form...

journal_title：Cell

authors： Bar-Peled L,Schweitzer LD,Zoncu R,Sabatini DM

更新日期：2012-09-14 00:00:00

abstract：:Receptor-mediated endocytosis of specific ligands is mediated through clustering of receptor-ligand complexes in coated pits on the cell surface. Following this clustering event, the ligand is internalized into a noncoated intracellular vesicle, the receptosome, which selectively avoids fusion with lysosomes and moves...

journal_title：Cell

authors： Willingham MC,Pastan I

更新日期：1980-08-01 00:00:00

abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...

journal_title：Cell

authors： Parish IA,Kaech SM

更新日期：2011-02-18 00:00:00

abstract：:An antiserum against material shed into serum-free medium by MCF-7 human mammary carcinoma cells (anti-SFM II) disrupts cell-cell interactions in murine mammary tumor epithelial cells (MMTE). We now report purification of an 80 kd glycoprotein (GP80) from SFM of MCF-7 mammary carcinoma cells that blocks the activity o...

journal_title：Cell

authors： Damsky CH,Richa J,Solter D,Knudsen K,Buck CA

更新日期：1983-09-01 00:00:00

abstract：:Protein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils. Using quantitative proteomics, we found that the toxicity of ...

journal_title：Cell

authors： Olzscha H,Schermann SM,Woerner AC,Pinkert S,Hecht MH,Tartaglia GG,Vendruscolo M,Hayer-Hartl M,Hartl FU,Vabulas RM

更新日期：2011-01-07 00:00:00

abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...

journal_title：Cell

authors： Clarkson SG,Kurer V,Smith HO

更新日期：1978-07-01 00:00:00

abstract：:Production of nerve growth factor (NGF) was assessed in cultures of human T and B lymphocytes and macrophages. NGF was constitutively produced by B cells only, which also expressed surface p140trk-A and p75NGFR molecules and hence efficiently bound and internalized the cytokine. Neutralization of endogenous NGF caused...

journal_title：Cell

authors： Torcia M,Bracci-Laudiero L,Lucibello M,Nencioni L,Labardi D,Rubartelli A,Cozzolino F,Aloe L,Garaci E

更新日期：1996-05-03 00:00:00

abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

journal_title：Cell

authors： Opresko L,Wiley HS,Wallace RA

更新日期：1980-11-01 00:00:00

abstract：:Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain pro...

journal_title：Cell

authors： Daumke O,Roux A,Haucke V

更新日期：2014-02-27 00:00:00

abstract：:Specification of the germ cell lineage is vital to development and heredity. In mice, the germ cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying mechanism remains unknown. Here we demonstrate that germ cell fate in the epiblast is a direct consequence of Bmp4 signaling from ...

journal_title：Cell

authors： Ohinata Y,Ohta H,Shigeta M,Yamanaka K,Wakayama T,Saitou M

更新日期：2009-05-01 00:00:00

abstract：:The mechanism by which nucleosome cores are displaced and re-formed during transcription in vitro has been investigated. A nucleosome core was assembled on a short linear DNA template (227 bp) containing an SP6 RNA polymerase promoter and a nucleosome-positioning sequence. Transcription induced the translocation of th...

journal_title：Cell

authors： Studitsky VM,Clark DJ,Felsenfeld G

更新日期：1994-01-28 00:00:00

abstract：:Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that gene regulatory elements and their target genes generally occur within insulated ...

journal_title：Cell

authors： Hnisz D,Day DS,Young RA

更新日期：2016-11-17 00:00:00

abstract：:Subcellular compartments in which folding and assembly of proteins occur seem to have a set of PCB proteins capable of mediating these and related processes, such as translocation across membranes. When a domain of a polypeptide chain emerges from a ribosome during synthesis or from the distal side of a membrane durin...

journal_title：Cell

authors： Rothman JE

更新日期：1989-11-17 00:00:00

abstract：:Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of the D-loop region. This part of the mammalian mitochondrial genome is known to contain the origin of heavy strand DNA synthesis and the major transcriptional p...

journal_title：Cell

authors： Hauswirth WW,Van de Walle MJ,Laipis PJ,Olivo PD

更新日期：1984-07-01 00:00:00

abstract：:Ras-related GTPases are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain GEF bound to nucleotide-free ARF1 GTPase has been determined at 2.8 A resolution and the structure of ARF1 in the GTP-analog form determined at 1...

journal_title：Cell

authors： Goldberg J

更新日期：1998-10-16 00:00:00