Abstract：
:Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain protein superfamily constrain the membrane into distinct shapes as the pathway progresses toward fission by the GTPase dynamin. In this Review, we discuss how BAR domain protein assembly and disassembly are controlled in space and time and which structural and biochemical features allow the tight regulation of their shape and function to enable dynamin-mediated membrane fission.
journal_name
Celljournal_title
Cellauthors
Daumke O,Roux A,Haucke Vdoi
10.1016/j.cell.2014.02.017subject
Has Abstractpub_date
2014-02-27 00:00:00pages
882-92issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00211-6journal_volume
156pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlying IHC synaptic exocytosis are largely unknown. We studied otoferlin, a predicted C2-domain transmembrane protein, which is...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.08.040
更新日期：2006-10-20 00:00:00
abstract：:Excessive accumulation of neurofilaments in the cell bodies and proximal axons of motor neurons is a major pathological hallmark during the early stages of many human motor neuron diseases. To test directly the consequence of overexpression of the major neurofilament subunit NF-L, we produced transgenic mice that accu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90157-l
更新日期：1993-04-09 00:00:00
abstract：:The murine major histocompatibility complex I region encodes two class II antigens, I-A and I-E. From a mouse spleen DNA cosmid library of the b haplotype, we isolated a clone containing the entire I-A beta gene and a separate exon encoding a beta-chain second domain (A beta 2). The A beta gene, encompassing more than...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90148-4
更新日期：1983-08-01 00:00:00
abstract：:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription fact...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00596-7
更新日期：2001-12-14 00:00:00
abstract：:A family of novel substrates was designed to enable the efficient accumulation of intermediates in site-specific recombination. Strategically placed nicks allow these "suicide substrates" to initiate the reaction but prevent its completion or reversal. Consequently, it has been possible to determine that lambda site-s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90336-9
更新日期：1987-08-28 00:00:00
abstract：:Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells expressing M-tropic, but not T-tropic, HIV-1 env proteins. Expression of CKR-5 and CD4 enables entry of a M-tropic, but not a T-tropic...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81314-8
更新日期：1996-06-28 00:00:00
abstract：:Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.02.047
更新日期：2018-04-05 00:00:00
abstract：:In this issue of Cell, use live-fluorescence microscopy to monitor individual genomic loci as they replicate in budding yeast. They confirm that DNA is recruited to replication factories and show that sister replication forks initiated from the same origin are held together within a single replication factory. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.06.014
更新日期：2006-06-30 00:00:00
abstract：:Voltage-gated calcium channels play a central role in regulating the electrical and biochemical properties of neurons and muscle cells. One of the ways in which calcium channels regulate long-lasting neuronal properties is by activating signaling pathways that control gene expression, but the mechanisms that link calc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.10.017
更新日期：2006-11-03 00:00:00
abstract：:Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.05.036
更新日期：2012-07-20 00:00:00
abstract：:The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.06.026
更新日期：2017-06-29 00:00:00
abstract：:We have constructed a gene fusion using the promoter of Drosophila hsp70 and the structural gene for Drosophila alcohol dehydrogenase (Adh) and used this construct to transform Adh-deficient flies. In these transformants, Adh is expressed only after heat shock. Like hsp70 itself, this heat-shock-inducible Adh (Adhhs) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90432-x
更新日期：1984-07-01 00:00:00
abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90033-9
更新日期：1992-03-06 00:00:00
abstract：:We have isolated cDNA clones generated from the mRNA encoding the opsin apoprotein of bovine rhodopsin and used these cDNAs to isolate genomic DNA clones containing the complete opsin gene. Nucleotide sequence analysis of the cloned DNAs has yielded a complete amino acid sequence for bovine rhodopsin and provided an i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90537-8
更新日期：1983-10-01 00:00:00
abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90051-x
更新日期：1978-12-01 00:00:00
abstract：:E. coli sigma 54 protein confers on promoters containing its recognition sequence the ability to be activated from distant DNA sites. Its functional domains include two leucine zipper motifs, an acidic region, and a glutamine-rich domain. Several domains were disrupted and the assembly of mutant transcription complexe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90269-k
更新日期：1990-09-07 00:00:00
abstract：:Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarily one intermediate filament protein: vimentin. Desmin synthesis is initiated at the onset of fusion. Synthesis rates of bo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90408-0
更新日期：1980-01-01 00:00:00
abstract：:We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90597-6
更新日期：1992-11-13 00:00:00
abstract：:Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90182-3
更新日期：1976-05-01 00:00:00
abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.07.015
更新日期：2019-08-08 00:00:00
abstract：:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90021-0
更新日期：1976-02-01 00:00:00
abstract：:The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90189-9
更新日期：1987-02-13 00:00:00
abstract：:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90614-v
更新日期：1993-12-31 00:00:00
abstract：:Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00632-3
更新日期：2002-02-08 00:00:00
abstract：:The mitotic checkpoint prevents advance to anaphase prior to successful attachment of every centromere/kinetochore to mitotic spindle microtubules. Using purified components and Xenopus egg extracts, the kinetochore-associated microtubule motor CENP-E is now shown to be the activator of the essential checkpoint kinase...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00475-6
更新日期：2003-07-11 00:00:00
abstract：:Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a ne...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.12.003
更新日期：2010-12-23 00:00:00
abstract：:Treating B16 mouse melanoma cells with monoclonal antibody NORM-2 reduces cell growth in tissue culture, agar, and syngeneic mice. We show that the NORM-2 antibody recognizes an integral 83 kd glycoprotein that is mobile in the plane of the plasma membrane of B16 melanoma cells. Expression of the glycoprotein is reduc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90510-6
更新日期：1986-12-05 00:00:00
abstract：:Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, bu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.10.033
更新日期：2012-11-09 00:00:00
abstract：:The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.10.053
更新日期：2009-01-09 00:00:00
abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.08.020
更新日期：2006-09-08 00:00:00
