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PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.

Abstract：

:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously been implicated in both long-term potentiation (LTP) and learning and memory. These mice have a modified LTP of synaptic transmission in the hippocampus. We demonstrate that PKC gamma-mutant mice can learn to carry out hippocampus-dependent tasks, although mild deficits are evident. Thus, hippocampal CA1 LTP induced by the conventional tetanic stimulation is not essential for the mice to exhibit spatial and contextual learning. Furthermore, the modification of hippocampal synaptic plasticity correlates with the learning deficits we observe.

journal_name

Cell

journal_title

Cell

authors

Abeliovich A,Paylor R,Chen C,Kim JJ,Wehner JM,Tonegawa S

doi

10.1016/0092-8674(93)90614-v

subject

Has Abstract

pub_date

1993-12-31 00:00:00

pages

1263-71

issue

7

eissn

0092-8674

issn

1097-4172

pii

0092-8674(93)90614-V

journal_volume

75

pub_type

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