Abstract:
:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of estrogen. Furthermore, an autonomous tumor derived from the Shionogi SC-115 cells produced fibrinolytic activity independent of added DHT or estrogen. These observations suggest a close correlation between fibrinolytic activity of a tumor and its ability to grow in vivo.
journal_name
Celljournal_title
Cellauthors
Mak TW,Rutledge G,Sutherland DJdoi
10.1016/0092-8674(76)90021-0subject
Has Abstractpub_date
1976-02-01 00:00:00pages
223-6issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(76)90021-0journal_volume
7pub_type
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