Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon.

abstract：:The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...

journal_title：Cell

authors： Chen H,Nwe PK,Yang Y,Rosen CE,Bielecka AA,Kuchroo M,Cline GW,Kruse AC,Ring AM,Crawford JM,Palm NW

更新日期：2019-05-16 00:00:00

abstract：:Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...

journal_title：Cell

authors： Steward O

更新日期：2002-09-06 00:00:00

abstract：:Developmental analysis of a newly isolated maternal effect grandchildless mutant, tudor (tud), in Drosophila melanogaster indicates that tud+ activity is required during oogenesis for the determination and/or formation of primordial germ cells (pole cells) and for normal embryonic abdominal segmentation. Regardless of...

journal_title：Cell

authors： Boswell RE,Mahowald AP

更新日期：1985-11-01 00:00:00

abstract：:Rosalind Franklin provided the key data for deriving the double helix structure of DNA. The English chemist also pioneered structural studies of colloids, viruses, and RNA. To celebrate the 100th anniversary of Franklin's birth, I summarize her work, which shaped the emerging discipline of molecular biology. ...

journal_title：Cell

authors： Cramer P

更新日期：2020-08-20 00:00:00

abstract：:The rps12 gene codes for chloroplast ribosomal protein S12. In the tobacco chloroplast genome (156 kbp circular DNA), exons II and III of this gene are separated by an intron of 536 bases and are present in two copies in the inverted repeat region, while exon I is located in the large single copy region at a distance ...

journal_title：Cell

authors： Koller B,Fromm H,Galun E,Edelman M

更新日期：1987-01-16 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins...

journal_title：Cell

authors： Schuettengruber B,Chourrout D,Vervoort M,Leblanc B,Cavalli G

更新日期：2007-02-23 00:00:00

abstract：:Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metab...

journal_title：Cell

authors： Buck MD,Sowell RT,Kaech SM,Pearce EL

更新日期：2017-05-04 00:00:00

abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...

journal_title：Cell

authors： Stock J,Kersulis G,Koshland DE Jr

更新日期：1985-09-01 00:00:00

abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...

journal_title：Cell

authors： Lisby M,Barlow JH,Burgess RC,Rothstein R

更新日期：2004-09-17 00:00:00

abstract：:We have isolated spontaneous temperature-resistant revertants of a temperature-sensitive mutation (rpoD800) in the sigma subunit of E. coli K12 RNA polymerase. These revertants still contained the rpoD800 allele. They were mucoid, and sensitive to ultraviolet light and the radiomimetic agent nitrofurantoin, which are ...

journal_title：Cell

authors： Grossman AD,Burgess RR,Walter W,Gross CA

更新日期：1983-01-01 00:00:00

abstract：:Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate ce...

journal_title：Cell

authors： Tan L,Zhang KX,Pecot MY,Nagarkar-Jaiswal S,Lee PT,Takemura SY,McEwen JM,Nern A,Xu S,Tadros W,Chen Z,Zinn K,Bellen HJ,Morey M,Zipursky SL

更新日期：2015-12-17 00:00:00

abstract：:At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-M...

journal_title：Cell

authors： Zakharyevich K,Tang S,Ma Y,Hunter N

更新日期：2012-04-13 00:00:00

abstract：:Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...

journal_title：Cell

authors： Hill CS,Marais R,John S,Wynne J,Dalton S,Treisman R

更新日期：1993-04-23 00:00:00

abstract：:Actomyosin retrograde flow underlies the contraction essential for cell motility. Retrograde flow in both lamellipodia and lamella is required for membrane protrusion and for force generation by coupling to cell adhesion. We report that the Rac/Cdc42-binding kinase MRCK and myosin II-related MYO18A linked by the adapt...

journal_title：Cell

authors： Tan I,Yong J,Dong JM,Lim L,Leung T

更新日期：2008-10-03 00:00:00

abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...

journal_title：Cell

authors： Qiang L,Accili D

更新日期：2012-02-03 00:00:00

abstract：:Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their epidermal and muscle stem cells retain a robustly rhythmic core circadian machinery. However, the osci...

journal_title：Cell

authors： Solanas G,Peixoto FO,Perdiguero E,Jardí M,Ruiz-Bonilla V,Datta D,Symeonidi A,Castellanos A,Welz PS,Caballero JM,Sassone-Corsi P,Muñoz-Cánoves P,Benitah SA

更新日期：2017-08-10 00:00:00

abstract：:The subcellular localization of the mouse Ltk transmembrane protein tyrosine kinase was studied in transfected COS cells, a mature B lymphocyte line, and a low expressing transfected lymphocyte clone. Indirect immunofluorescence and immunogold staining of COS transfectants and endoglycosidase analysis of both COS tran...

journal_title：Cell

authors： Bauskin AR,Alkalay I,Ben-Neriah Y

更新日期：1991-08-23 00:00:00

abstract：:Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change the...

journal_title：Cell

authors： Parks S,Wieschaus E

更新日期：1991-01-25 00:00:00

abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...

journal_title：Cell

authors： Chen J,Lee KH,Steinhauer DA,Stevens DJ,Skehel JJ,Wiley DC

更新日期：1998-10-30 00:00:00

abstract：:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target gen...

journal_title：Cell

authors： Piccolo S

更新日期：2008-05-30 00:00:00

abstract：:Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...

journal_title：Cell

authors： Changeux JP,Christopoulos A

更新日期：2016-08-25 00:00:00

abstract：:Hybrid transducing phages were constructed in vitro that carry the galK gene fused to each of three ribosomal promoters: the promotor for an rRNA operon (rrnE); the promoter for the spec r protein operon and the promotor for the alpha r protein operon. We also constructed hybrid transducing phages that carry the IacZ ...

journal_title：Cell

authors： Miura A,Krueger JH,Itoh S,de Boer HA,Nomura M

更新日期：1981-09-01 00:00:00

abstract：:The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible expression of the human hsp70 gene. Among the four transcription factors that bind to the human hsp70 promoter, the DNA-binding activities of three (C/EBP, GBP, and HSF1) were normal, while Sp1 showed reduced binding activ...

journal_title：Cell

authors： Martínez-Balbás MA,Dey A,Rabindran SK,Ozato K,Wu C

更新日期：1995-10-06 00:00:00

abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...

journal_title：Cell

authors： Shamanski FL,Orr-Weaver TL

更新日期：1991-09-20 00:00:00

abstract：:Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...

journal_title：Cell

authors： Boj SF,Hwang CI,Baker LA,Chio II,Engle DD,Corbo V,Jager M,Ponz-Sarvise M,Tiriac H,Spector MS,Gracanin A,Oni T,Yu KH,van Boxtel R,Huch M,Rivera KD,Wilson JP,Feigin ME,Öhlund D,Handly-Santana A,Ardito-Abraham CM,L

更新日期：2015-01-15 00:00:00

abstract：:In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...

journal_title：Cell

authors： Suganuma T,Mushegian A,Swanson SK,Abmayr SM,Florens L,Washburn MP,Workman JL

更新日期：2010-09-03 00:00:00

abstract：:Study of Asians has previously indicated that deletion of alpha-globin structural genes is the predominant lesion in alpha-thalassemias and that Hb H disease occurs when three of four normal alpha loci per cell are deleted. To test the generality of this model, Hb H disease DNAs of both Asian and non-Asian origin were...

journal_title：Cell

authors： Orkin SH,Old J,Lazarus H,Altay C,Gurgey A,Weatherall DJ,Nathan DG

更新日期：1979-05-01 00:00:00

abstract：:The Xist gene maps to the X inactivation center region in both mouse and human, and previous analysis of the 3' end of the gene has demonstrated inactive X-specific expression, suggesting a possible role in X inactivation. We have now analyzed the entire mouse Xist gene. The mature inactive X-specific transcript is 15...

journal_title：Cell

authors： Brockdorff N,Ashworth A,Kay GF,McCabe VM,Norris DP,Cooper PJ,Swift S,Rastan S

更新日期：1992-10-30 00:00:00

abstract：:The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a clas...

journal_title：Cell

authors： Codelia VA,Irvine KD

更新日期：2012-08-17 00:00:00