Abstract:
:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.
journal_name
Celljournal_title
Cellauthors
Piccolo Sdoi
10.1016/j.cell.2008.05.013subject
Has Abstractpub_date
2008-05-30 00:00:00pages
767-9issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(08)00628-4journal_volume
133pub_type
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