p53 regulation orchestrates the TGF-beta response.

Abstract:

:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.

journal_name

Cell

journal_title

Cell

authors

Piccolo S

doi

10.1016/j.cell.2008.05.013

subject

Has Abstract

pub_date

2008-05-30 00:00:00

pages

767-9

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(08)00628-4

journal_volume

133

pub_type

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