Genome regulation by polycomb and trithorax proteins.

abstract：:Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...

journal_title：Cell

authors： Steculorum SM,Ruud J,Karakasilioti I,Backes H,Engström Ruud L,Timper K,Hess ME,Tsaousidou E,Mauer J,Vogt MC,Paeger L,Bremser S,Klein AC,Morgan DA,Frommolt P,Brinkkötter PT,Hammerschmidt P,Benzing T,Rahmouni K,Wunder

更新日期：2016-03-24 00:00:00

abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...

journal_title：Cell

authors： Bates P,Young JA,Varmus HE

更新日期：1993-09-24 00:00:00

abstract：:The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy meth...

journal_title：Cell

authors： Terasaki M,Shemesh T,Kasthuri N,Klemm RW,Schalek R,Hayworth KJ,Hand AR,Yankova M,Huber G,Lichtman JW,Rapoport TA,Kozlov MM

更新日期：2013-07-18 00:00:00

abstract：:When treated with the synthetic glucocorticoid dexamethasone, HT1080 human fibrosarcoma cells show changes in morphology, adhesion, and the extracellular matrix. Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal...

journal_title：Cell

authors： Oliver N,Newby RF,Furcht LT,Bourgeois S

更新日期：1983-05-01 00:00:00

abstract：:The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The consequence of this mutation is the substitution of the carboxy-terminal 4...

journal_title：Cell

authors： Kleyn PW,Fan W,Kovats SG,Lee JJ,Pulido JC,Wu Y,Berkemeier LR,Misumi DJ,Holmgren L,Charlat O,Woolf EA,Tayber O,Brody T,Shu P,Hawkins F,Kennedy B,Baldini L,Ebeling C,Alperin GD,Deeds J,Lakey ND,Culpepper J,Chen

更新日期：1996-04-19 00:00:00

abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

journal_title：Cell

authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

更新日期：2005-02-11 00:00:00

abstract：:Two allelic forms of the natural chicken ovalbumin gene have been independently cloned. These alleles differ from each other by an Eco RI restriction cleavage site in one of the seven intervening sequences within the natural ovalbumin gene. Restriction endonuclease mapping and sequence analyses of these cloned genotyp...

journal_title：Cell

authors： Lai EC,Woo SL,Dugaiczyk A,O'Malley BW

更新日期：1979-01-01 00:00:00

abstract：:X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...

journal_title：Cell

authors： Lee JT,Strauss WM,Dausman JA,Jaenisch R

更新日期：1996-07-12 00:00:00

abstract：:A mechanistic description of metazoan transcription is essential for understanding the molecular processes that govern cellular decisions. To provide structural insights into the DNA recognition step of transcription initiation, we used single-particle electron microscopy (EM) to visualize human TFIID with promoter DN...

journal_title：Cell

authors： Cianfrocco MA,Kassavetis GA,Grob P,Fang J,Juven-Gershon T,Kadonaga JT,Nogales E

更新日期：2013-01-17 00:00:00

abstract：:The human multidrug resistance P-glycoprotein is an active transporter that pumps cytotoxic drugs out of cells. Expression of P-glycoprotein is also associated with a volume-activated chloride channel. Here we address the relationship between these two functions. Drug transport requires ATP hydrolysis while, in contra...

journal_title：Cell

authors： Gill DR,Hyde SC,Higgins CF,Valverde MA,Mintenig GM,Sepúlveda FV

更新日期：1992-10-02 00:00:00

abstract：:The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates...

journal_title：Cell

authors： Scaglioni PP,Yung TM,Cai LF,Erdjument-Bromage H,Kaufman AJ,Singh B,Teruya-Feldstein J,Tempst P,Pandolfi PP

更新日期：2006-07-28 00:00:00

abstract：:The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either ribosomes or the Sec62/63 complex to perform co- and posttranslational transport, respectively. We show by electron microscopy that purified mammalian and yeast S...

journal_title：Cell

authors： Hanein D,Matlack KE,Jungnickel B,Plath K,Kalies KU,Miller KR,Rapoport TA,Akey CW

更新日期：1996-11-15 00:00:00

abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...

journal_title：Cell

authors： Nishimura I,Yang Y,Lu B

更新日期：2004-03-05 00:00:00

abstract：:Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating long-range diffusible inhibitors or by sequestering essential polarity components. We use morphologica...

journal_title：Cell

authors： Houk AR,Jilkine A,Mejean CO,Boltyanskiy R,Dufresne ER,Angenent SB,Altschuler SJ,Wu LF,Weiner OD

更新日期：2012-01-20 00:00:00

abstract：:The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover f...

journal_title：Cell

authors： Irie K,Nomoto S,Miyajima I,Matsumoto K

更新日期：1991-05-31 00:00:00

abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...

journal_title：Cell

authors： Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,

更新日期：2019-05-30 00:00:00

abstract：:CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV). Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3G is a DNA deaminase that is incorporated into virions during viral pr...

journal_title：Cell

authors： Harris RS,Bishop KN,Sheehy AM,Craig HM,Petersen-Mahrt SK,Watt IN,Neuberger MS,Malim MH

更新日期：2003-06-13 00:00:00

abstract：:Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. Here, we report the crystal structure of the heterophilic adhesion comp...

journal_title：Cell

authors： Wang JH,Smolyar A,Tan K,Liu JH,Kim M,Sun ZY,Wagner G,Reinherz EL

更新日期：1999-06-11 00:00:00

abstract：:Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...

journal_title：Cell

authors： Simunovic M,Manneville JB,Renard HF,Evergren E,Raghunathan K,Bhatia D,Kenworthy AK,Voth GA,Prost J,McMahon HT,Johannes L,Bassereau P,Callan-Jones A

更新日期：2017-06-29 00:00:00

abstract：:Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their target selectivity...

journal_title：Cell

authors： Knight ZA,Gonzalez B,Feldman ME,Zunder ER,Goldenberg DD,Williams O,Loewith R,Stokoe D,Balla A,Toth B,Balla T,Weiss WA,Williams RL,Shokat KM

更新日期：2006-05-19 00:00:00

abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

journal_title：Cell

authors： Opresko L,Wiley HS,Wallace RA

更新日期：1980-11-01 00:00:00

abstract：:Gastric acid secretion is mediated by the H/K-ATPase of parietal cells. Activation of acid secretion involves insertion of H/K-ATPase into the parietal cell plasmalemma, while its cessation is associated with reinternalization of the H/K-ATPase into an intracellular storage compartment. The cytoplasmic tail of the H/K...

journal_title：Cell

authors： Courtois-Coutry N,Roush D,Rajendran V,McCarthy JB,Geibel J,Kashgarian M,Caplan MJ

更新日期：1997-08-08 00:00:00

abstract：:The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...

journal_title：Cell

authors： Moor AE,Harnik Y,Ben-Moshe S,Massasa EE,Rozenberg M,Eilam R,Bahar Halpern K,Itzkovitz S

更新日期：2018-11-01 00:00:00

abstract：:The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of y...

journal_title：Cell

authors： Warren AJ,Colledge WH,Carlton MB,Evans MJ,Smith AJ,Rabbitts TH

更新日期：1994-07-15 00:00:00

abstract：:Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA...

journal_title：Cell

authors： Piper DE,Batchelor AH,Chang CP,Cleary ML,Wolberger C

更新日期：1999-02-19 00:00:00

abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...

journal_title：Cell

authors： Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

更新日期：2010-06-11 00:00:00

abstract：:We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appre...

journal_title：Cell

authors： Kappler JW,Wade T,White J,Kushnir E,Blackman M,Bill J,Roehm N,Marrack P

更新日期：1987-04-24 00:00:00

abstract：:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...

journal_title：Cell

authors： Clapham DE

更新日期：2009-03-06 00:00:00

abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...

journal_title：Cell

authors： Symons M,Derry JM,Karlak B,Jiang S,Lemahieu V,Mccormick F,Francke U,Abo A

更新日期：1996-03-08 00:00:00

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00