A STIMulus Package puts orai calcium channels to work.

Abstract:

:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this channel.

journal_name

Cell

journal_title

Cell

authors

Clapham DE

doi

10.1016/j.cell.2009.02.022

subject

Has Abstract

pub_date

2009-03-06 00:00:00

pages

814-6

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(09)00198-6

journal_volume

136

pub_type

评论,社论

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