Abstract：
:Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicity regulate the diurnally shifting SI epithelial cell (SIEC) transcriptional landscape through modulation of the SI microbiome. We exemplify this concept with SIEC major histocompatibility complex (MHC) class II, which is diurnally modulated by distinct mucosal-adherent SI commensals, while supporting downstream diurnal activity of intra-epithelial IL-10+ lymphocytes regulating the SI barrier function. Disruption of this diurnally regulated diet-microbiome-MHC class II-IL-10-epithelial barrier axis by circadian clock disarrangement, alterations in feeding time or content, or epithelial-specific MHC class II depletion leads to an extensive microbial product influx, driving Crohn-like enteritis. Collectively, we highlight nutritional features that modulate SI microbiome, immunity, and barrier function and identify dietary, epithelial, and immune checkpoints along this axis to be potentially exploitable in future Crohn disease interventions.
journal_name
Celljournal_title
Cellauthors
Tuganbaev T,Mor U,Bashiardes S,Liwinski T,Nobs SP,Leshem A,Dori-Bachash M,Thaiss CA,Pinker EY,Ratiner K,Adlung L,Federici S,Kleimeyer C,Moresi C,Yamada T,Cohen Y,Zhang X,Massalha H,Massasa E,Kuperman Y,Koni PA,Hdoi
10.1016/j.cell.2020.08.027subject
Has Abstractpub_date
2020-09-17 00:00:00pages
1441-1459.e21issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(20)31069-2journal_volume
182pub_type
杂志文章相关文献
CELL文献大全abstract：:In prokaryotes, the toxin-antitoxin systems are thought to play important roles in growth regulation under stress conditions. In the E. coli MazE-MazF system, MazF toxin functions as an mRNA interferase cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest. Myxococcus xanthus is a ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.11.044
更新日期：2008-01-11 00:00:00
abstract：:Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.08.022
更新日期：2009-09-04 00:00:00
abstract：:In normal human fibroblasts, the synthesis of a cell surface receptor for plasma low density lipoprotein (LDL) is regulated by a sensitive system of feedback suppression. The number of functional LDL receptors declines by more than 20 fold when cellular stores of esterified cholesterol are increased by incubation of c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90110-0
更新日期：1976-10-01 00:00:00
abstract：:The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor β (PDGFRβ). PDGFRβ-Cre-driven reporter gene recombinatio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.05.032
更新日期：2012-07-06 00:00:00
abstract：:Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.09.006
更新日期：2016-09-22 00:00:00
abstract：:The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.07.032
更新日期：2012-09-14 00:00:00
abstract：:The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA is surface exposed and exported from bacterial cells. Outer-membrane vesicles (OMVs) released from the bacteria were shown...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00754-2
更新日期：2003-10-03 00:00:00
abstract：:Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.05.016
更新日期：2014-06-19 00:00:00
abstract：:Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90349-0
更新日期：1979-09-01 00:00:00
abstract：:The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.01.016
更新日期：2012-02-03 00:00:00
abstract：:The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90097-7
更新日期：1995-11-17 00:00:00
abstract：:An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal tissues -- whether used alone or in combination with currently approved drugs -- would change the way we treat cancer. In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental gro...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2007.10.023
更新日期：2007-11-02 00:00:00
abstract：:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.06.002
更新日期：2014-06-19 00:00:00
abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s0092-8674(01)00509-8
更新日期：2001-10-05 00:00:00
abstract：:The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90145-8
更新日期：1981-02-01 00:00:00
abstract：:Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized. We demonstrate physiologic regulation of Dictyostelium chemotaxis by InsP7 mediated ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00640-8
更新日期：2003-09-05 00:00:00
abstract：:Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80712-6
更新日期：1999-04-02 00:00:00
abstract：:In Saccharomyces cerevisiae, known histone acetylation sites regulating gene activity are located in the N-terminal tails protruding from the nucleosome core. We report lysine 56 in histone H3 as a novel acetylation site that is located in the globular domain, where it extends toward the DNA major groove at the entry-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.011
更新日期：2005-05-06 00:00:00
abstract：:The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface. We show that immature CD4(+)CD8(+) double-positive...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00577-3
更新日期：2001-11-16 00:00:00
abstract：:The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The consequence of this mutation is the substitution of the carboxy-terminal 4...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81104-6
更新日期：1996-04-19 00:00:00
abstract：:We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90343-9
更新日期：1982-02-01 00:00:00
abstract：:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription fact...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00596-7
更新日期：2001-12-14 00:00:00
abstract：:An injection of aphidicolin into early Drosophila embryos inhibits DNA synthesis and nuclear division, while centrosome replication and many other aspects of the mitotic cycle continue. If aphidicolin is injected at nuclear cycle 7-8, the normal migration of nuclei to the embryo cortex is completely inhibited. In most...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90130-x
更新日期：1989-05-19 00:00:00
abstract：:Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, but the mechanism of autophagy targeting and its role in natural inf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.06.040
更新日期：2012-08-17 00:00:00
abstract：:Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00003-5
更新日期：2003-01-24 00:00:00
abstract：:Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.025
更新日期：2014-01-30 00:00:00
abstract：:During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different di...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.012
更新日期：2018-11-29 00:00:00
abstract：:The eukaryotic 20S proteasome is known to associate with the IFN gamma-inducible regulator PA28. We analyzed the kinetics of product generation by 20S proteasomes with and without PA28. In the absence of PA28, the 20S proteasome rapidly generates peptides that have been cleaved only once, while internal fragments accu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80097-5
更新日期：1996-07-26 00:00:00
abstract：:Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin assisted by specialized assembly factors. Whereas core subunits are translated on mitochondrial ribosomes, others are imported after cytosolic translation. How imported subunits are ushered to assembly intermediates containing mito...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.11.053
更新日期：2012-12-21 00:00:00
abstract：:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.05.028
更新日期：2008-06-13 00:00:00
