Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle.

abstract：:Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...

journal_title：Cell

authors： Gao H,Chakraborty G,Zhang Z,Akalay I,Gadiya M,Gao Y,Sinha S,Hu J,Jiang C,Akram M,Brogi E,Leitinger B,Giancotti FG

更新日期：2016-06-30 00:00:00

abstract：:We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster. Experiments using genomic Drosophila DNA from several sources indicate that there are at least four copies each of the alpha-tubulin gene and the beta-tubulin gene. In situ hybrid...

journal_title：Cell

authors： Sánchez F,Natzle JE,Cleveland DW,Kirschner MW,McCarthy BJ

更新日期：1980-12-01 00:00:00

abstract：:Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis....

journal_title：Cell

authors： Fredrick K,Ibba M

更新日期：2010-04-16 00:00:00

abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

journal_title：Cell

authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

更新日期：2012-08-03 00:00:00

abstract：:Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. ...

journal_title：Cell

authors： Yin Y,Tainsky MA,Bischoff FZ,Strong LC,Wahl GM

更新日期：1992-09-18 00:00:00

abstract：:A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

journal_title：Cell

authors： Gaul U,Mardon G,Rubin GM

更新日期：1992-03-20 00:00:00

abstract：:AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...

journal_title：Cell

authors： Chen S,Zhao Y,Wang Y,Shekhar M,Tajkhorshid E,Gouaux E

更新日期：2017-09-07 00:00:00

abstract：:We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino a...

journal_title：Cell

authors： Cate RL,Mattaliano RJ,Hession C,Tizard R,Farber NM,Cheung A,Ninfa EG,Frey AZ,Gash DJ,Chow EP

更新日期：1986-06-06 00:00:00

abstract：:The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal...

journal_title：Cell

authors： Hegde AN,Inokuchi K,Pei W,Casadio A,Ghirardi M,Chain DG,Martin KC,Kandel ER,Schwartz JH

更新日期：1997-04-04 00:00:00

abstract：:The unfolded protein response (UPR) regulates gene expression in response to stress in the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using DNA microarrays. Rather than regulating only ER-resident chaperones and phospholipid biosynthesis, as anticipated from earlier work, the UPR af...

journal_title：Cell

authors： Travers KJ,Patil CK,Wodicka L,Lockhart DJ,Weissman JS,Walter P

更新日期：2000-04-28 00:00:00

abstract：:Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicit...

journal_title：Cell

authors： Tuganbaev T,Mor U,Bashiardes S,Liwinski T,Nobs SP,Leshem A,Dori-Bachash M,Thaiss CA,Pinker EY,Ratiner K,Adlung L,Federici S,Kleimeyer C,Moresi C,Yamada T,Cohen Y,Zhang X,Massalha H,Massasa E,Kuperman Y,Koni PA,H

更新日期：2020-09-17 00:00:00

abstract：:We have analyzed the structure of the Shrunken (Sh) locus in a strain containing an unstable recessive mutation, sh-m5933, caused by the transposable controlling element Dissociation (Ds). We have also analyzed nine spontaneous Sh revertant alleles. The sh-m5933 allele contains a 30 kb insertion at the Sh locus, as we...

journal_title：Cell

authors： Courage-Tebbe U,Döring HP,Fedoroff N,Starlinger P

更新日期：1983-09-01 00:00:00

abstract：:The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic cor...

journal_title：Cell

authors： Hu M,Li P,Li M,Li W,Yao T,Wu JW,Gu W,Cohen RE,Shi Y

更新日期：2002-12-27 00:00:00

abstract：:To study the insertion of multispanning membrane proteins into the endoplasmic reticulum, we constructed novel proteins on the cDNA level by repeating, up to four times, the internal signal-anchor domain of the asialoglycoprotein receptor H1. Upon in vitro translation in the presence of microsomes, these polypeptides ...

journal_title：Cell

authors： Wessels HP,Spiess M

更新日期：1988-10-07 00:00:00

abstract：:VopL is an effector protein from Vibrio parahaemolyticus that nucleates actin filaments. VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs. Here, we report the crystal structure of the VCD dimer bound to actin. The VCD organizes three actin monomers in a spatial arrange...

journal_title：Cell

authors： Zahm JA,Padrick SB,Chen Z,Pak CW,Yunus AA,Henry L,Tomchick DR,Chen Z,Rosen MK

更新日期：2013-10-10 00:00:00

abstract：:The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to ...

journal_title：Cell

authors： Semenza GL

更新日期：2008-04-18 00:00:00

abstract：:Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions and a t(17;22) translocation, have been sequenced. A 4 kb sequence of the transcript of the TBR gene has been compared with sequences of genomi...

journal_title：Cell

authors： Cawthon RM,Weiss R,Xu GF,Viskochil D,Culver M,Stevens J,Robertson M,Dunn D,Gesteland R,O'Connell P

更新日期：1990-07-13 00:00:00

abstract：:At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...

journal_title：Cell

authors： Sullivan M,Higuchi T,Katis VL,Uhlmann F

更新日期：2004-05-14 00:00:00

abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

journal_title：Cell

authors： Takeya T,Hanafusa H

更新日期：1983-03-01 00:00:00

abstract：:The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown. Here, we show that the short and long 3' UTR BDNF mRNAs are involved in different cell...

journal_title：Cell

authors： An JJ,Gharami K,Liao GY,Woo NH,Lau AG,Vanevski F,Torre ER,Jones KR,Feng Y,Lu B,Xu B

更新日期：2008-07-11 00:00:00

abstract：:Activation of the cyclin-dependent kinases to promote cell cycle progression requires their association with cyclins as well as phosphorylation of a threonine (residue 161 in human p34cdc2). This phosphorylation is carried out by CAK, the Cdk-activating kinase. We have purified and cloned CAK from S. cerevisiae. Unlik...

journal_title：Cell

authors： Kaldis P,Sutton A,Solomon MJ

更新日期：1996-08-23 00:00:00

abstract：:Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta cell function and insulin action in peripheral tissues. We identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from t...

journal_title：Cell

authors： Chibalin AV,Leng Y,Vieira E,Krook A,Björnholm M,Long YC,Kotova O,Zhong Z,Sakane F,Steiler T,Nylén C,Wang J,Laakso M,Topham MK,Gilbert M,Wallberg-Henriksson H,Zierath JR

更新日期：2008-02-08 00:00:00

abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...

journal_title：Cell

authors： Giebelhaus DH,Eib DW,Moon RT

更新日期：1988-05-20 00:00:00

abstract：:The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...

journal_title：Cell

authors： Affara NI,Coussens LM

更新日期：2007-04-06 00:00:00

abstract：:Monkey cell lines that constitutively synthesize 38.6 kd lac repressor protein and bear stably integrated chloramphenicol acetyl transferase (CAT) genes linked to a lac operator-containing SV40 early promoter-enhancer were generated. When grown in medium containing isopropyl beta-D-thiogalactoside (IPTG), these cells ...

journal_title：Cell

authors： Figge J,Wright C,Collins CJ,Roberts TM,Livingston DM

更新日期：1988-03-11 00:00:00

abstract：:Enduring forms of synaptic plasticity and memory require new protein synthesis, but little is known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK signaling in these processes. Conditional expression of a dominant-negative form of MEK1 in the postnatal murine forebrain inhibited ERK ...

journal_title：Cell

authors： Kelleher RJ 3rd,Govindarajan A,Jung HY,Kang H,Tonegawa S

更新日期：2004-02-06 00:00:00

abstract：:Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo. ME...

journal_title：Cell

authors： Liu S,Hausmann S,Carlson SM,Fuentes ME,Francis JW,Pillai R,Lofgren SM,Hulea L,Tandoc K,Lu J,Li A,Nguyen ND,Caporicci M,Kim MP,Maitra A,Wang H,Wistuba II,Porco JA Jr,Bassik MC,Elias JE,Song J,Topisirovic I,Van

更新日期：2019-01-24 00:00:00

abstract：:RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for th...

journal_title：Cell

authors： Carter J,Hoffman C,Wiedenheft B

更新日期：2017-01-12 00:00:00

abstract：:Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry, and cellular microscopy that VP40 rearranges into different structures, each with a distinct function required for...

journal_title：Cell

authors： Bornholdt ZA,Noda T,Abelson DM,Halfmann P,Wood MR,Kawaoka Y,Saphire EO

更新日期：2013-08-15 00:00:00

abstract：:Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...

journal_title：Cell

authors： Resnitzky D,Yarden A,Zipori D,Kimchi A

更新日期：1986-07-04 00:00:00