Abstract:
:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?
journal_name
Celljournal_title
Cellauthors
Qiang L,Accili Ddoi
10.1016/j.cell.2012.01.020subject
Has Abstractpub_date
2012-02-03 00:00:00pages
397-8issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(12)00086-4journal_volume
148pub_type
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