FGF21 and the second coming of PPARγ.

Abstract:

:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?

journal_name

Cell

journal_title

Cell

authors

Qiang L,Accili D

doi

10.1016/j.cell.2012.01.020

subject

Has Abstract

pub_date

2012-02-03 00:00:00

pages

397-8

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(12)00086-4

journal_volume

148

pub_type

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