Abstract:
:Bacteria can respond to adverse environmental conditions by drastically reducing or even ceasing metabolic activity. They must then determine that conditions have improved before exiting dormancy, and one indication of such a change is the growth of other bacteria in the local environment. Growing bacteria release muropeptide fragments of the cell wall into the extracellular milieu, and we report here that these muropeptides are potent germinants of dormant Bacillus subtilis spores. The ability of a muropeptide to act as a germinant is determined by the identity of a single amino acid. A well-conserved, eukaryotic-like Ser/Thr membrane kinase containing an extracellular domain capable of binding peptidoglycan is necessary for this response, and a small molecule that stimulates related eukaryotic kinases is sufficient to induce germination. Another small molecule, staurosporine, that inhibits related eukaryotic kinases blocks muropeptide-dependent germination. Thus, in contrast to traditional antimicrobials that inhibit metabolically active cells, staurosporine acts by blocking germination of dormant spores.
journal_name
Celljournal_title
Cellauthors
Shah IM,Laaberki MH,Popham DL,Dworkin Jdoi
10.1016/j.cell.2008.08.039subject
Has Abstractpub_date
2008-10-31 00:00:00pages
486-96issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(08)01128-8journal_volume
135pub_type
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