Abstract:
:Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
journal_name
Celljournal_title
Cellauthors
Goldstein JL,DeBose-Boyd RA,Brown MSdoi
10.1016/j.cell.2005.12.022subject
Has Abstractpub_date
2006-01-13 00:00:00pages
35-46issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(05)01463-7journal_volume
124pub_type
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