Abstract:
:When transcription regulatory networks are compared among distantly related eukaryotes, a number of striking similarities are observed: a larger-than-expected number of genes, extensive overlapping connections, and an apparently high degree of functional redundancy. It is often assumed that the complexity of these networks represents optimized solutions, precisely sculpted by natural selection; their common features are often asserted to be adaptive. Here, we discuss support for an alternative hypothesis: the common structural features of transcription networks arise from evolutionary trajectories of "least resistance"--that is, the relative ease with which certain types of network structures are formed during their evolution.
journal_name
Celljournal_title
Cellauthors
Sorrells TR,Johnson ADdoi
10.1016/j.cell.2015.04.014subject
Has Abstractpub_date
2015-05-07 00:00:00pages
714-23issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(15)00431-6journal_volume
161pub_type
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