Abstract：
:During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives--rather than responds to--metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
journal_name
Celljournal_title
Cellauthors
Linneweber GA,Jacobson J,Busch KE,Hudry B,Christov CP,Dormann D,Yuan M,Otani T,Knust E,de Bono M,Miguel-Aliaga Idoi
10.1016/j.cell.2013.12.008subject
Has Abstractpub_date
2014-01-16 00:00:00pages
69-83issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01540-7journal_volume
156pub_type
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