A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.

abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...

journal_title：Cell

authors： Gee MH,Han A,Lofgren SM,Beausang JF,Mendoza JL,Birnbaum ME,Bethune MT,Fischer S,Yang X,Gomez-Eerland R,Bingham DB,Sibener LV,Fernandes RA,Velasco A,Baltimore D,Schumacher TN,Khatri P,Quake SR,Davis MM,Garcia KC

更新日期：2018-01-25 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and,...

journal_title：Cell

authors： Dennis JW,Nabi IR,Demetriou M

更新日期：2009-12-24 00:00:00

abstract：:cDNA clones of the Drosophila epidermal growth factor receptor homolog (DER) gene were isolated and sequenced. The deduced amino acid sequence shows a similar degree of homology to the human epidermal growth factor receptor and to the rat and human neu proteins; the most striking difference is the addition of a third ...

journal_title：Cell

authors： Schejter ED,Segal D,Glazer L,Shilo BZ

更新日期：1986-09-26 00:00:00

abstract：:This year's Albert Lasker Basic Medical Research Award honors David Allis and Michael Grunstein for their pioneering research that highlighted the importance of histones and their post-translational modifications in the direct control of gene expression. ...

journal_title：Cell

authors： Stillman B

更新日期：2018-09-20 00:00:00

abstract：:The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain a...

journal_title：Cell

authors： Li Y,Schnabl K,Gabler SM,Willershäuser M,Reber J,Karlas A,Laurila S,Lahesmaa M,U Din M,Bast-Habersbrunner A,Virtanen KA,Fromme T,Bolze F,O'Farrell LS,Alsina-Fernandez J,Coskun T,Ntziachristos V,Nuutila P,Klingenspor M

更新日期：2018-11-29 00:00:00

abstract：:During development, distinct classes of neurons are specified in precise locations along the dorso-ventral and anterior-posterior axes of the neural tube. We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary a...

journal_title：Cell

authors： Ye W,Shimamura K,Rubenstein JL,Hynes MA,Rosenthal A

更新日期：1998-05-29 00:00:00

abstract：:It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human protein, hRap1, that is an ortholog of the yeast telomeric protein, scRap1p. hRap1 has three conserved sequence motifs in common with scRap1, is loc...

journal_title：Cell

authors： Li B,Oestreich S,de Lange T

更新日期：2000-05-26 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (...

journal_title：Cell

authors： Soker S,Takashima S,Miao HQ,Neufeld G,Klagsbrun M

更新日期：1998-03-20 00:00:00

abstract：:Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to delineate the function of such biomolecular condensates in normal cells and their roles in contexts ranging from development to age-related ...

journal_title：Cell

authors： Alberti S,Gladfelter A,Mittag T

更新日期：2019-01-24 00:00:00

abstract：:A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding. Amino acid substitutions within two conserved and noncontiguous regions in the recombinant peptide abolis...

journal_title：Cell

authors： Michishita M,Videm V,Arnaout MA

更新日期：1993-03-26 00:00:00

abstract：:An approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (alphaPro221) in the first transm...

journal_title：Cell

authors： England PM,Zhang Y,Dougherty DA,Lester HA

更新日期：1999-01-08 00:00:00

abstract：:Certain mutations can cause proteins to accumulate in neurons, leading to neurodegeneration. We recently showed, however, that upregulation of a wild-type protein, Ataxin1, caused by haploinsufficiency of its repressor, the RNA-binding protein Pumilio1 (PUM1), also causes neurodegeneration in mice. We therefore search...

journal_title：Cell

authors： Gennarino VA,Palmer EE,McDonell LM,Wang L,Adamski CJ,Koire A,See L,Chen CA,Schaaf CP,Rosenfeld JA,Panzer JA,Moog U,Hao S,Bye A,Kirk EP,Stankiewicz P,Breman AM,McBride A,Kandula T,Dubbs HA,Macintosh R,Cardamone M

更新日期：2018-02-22 00:00:00

abstract：:The small ribonucleoproteins recognized by anti-La autoantibodies contain a heterogeneous mixture of small RNAs from uninfected mammalian cells. The identity of many of these has now been established by the discovery of precursor forms of 5S rRNA and of certain tRNAs among La RNAs from HeLa cells. The small fraction o...

journal_title：Cell

authors： Rinke J,Steitz JA

更新日期：1982-05-01 00:00:00

abstract：:A new type of mutation that affects a discrete step in the process of adsorptive endocytosis has been identified in one of 22 strains of fibroblasts derived from subjects with the clinical phenotype of homozygous familial hypercholesterolemia (FH). In this unique mutant strain (derived from subject J.D.), the cell sur...

journal_title：Cell

authors： Brown MS,Goldstein JL

更新日期：1976-12-01 00:00:00

abstract：:Is the Café Scientifique a fashionable by-product of a comfortable age or an indicator of the changing relationship between science and society? ...

journal_title：Cell

authors： Dallas D

更新日期：2006-07-28 00:00:00

abstract：:Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. We implemented this ...

journal_title：Cell

authors： Gupta PB,Onder TT,Jiang G,Tao K,Kuperwasser C,Weinberg RA,Lander ES

更新日期：2009-08-21 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

journal_title：Cell

authors： Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

更新日期：2008-09-19 00:00:00

abstract：:c-Abl is a tyrosine kinase localized primarily in the nucleus. Previous assays for abl function rely on cellular transformation by abl mutants, which are cytoplasmic. Using a conditional overexpression strategy, we have developed a functional assay for c-abl. Overexpression of c-abl inhibits growth by causing cell cyc...

journal_title：Cell

authors： Sawyers CL,McLaughlin J,Goga A,Havlik M,Witte O

更新日期：1994-04-08 00:00:00

abstract：:Most inducible transcriptional programs consist of primary and secondary response genes (PRGs and SRGs) that differ in their kinetics of expression and in their requirements for new protein synthesis and chromatin remodeling. Here we show that many PRGs, in contrast to SRGs, have preassembled RNA polymerase II (Pol II...

journal_title：Cell

authors： Hargreaves DC,Horng T,Medzhitov R

更新日期：2009-07-10 00:00:00

abstract：:Ovule development in Arabidopsis involves the formation of three morphologically defined proximal-distal pattern elements. Integuments arise from the central pattern element. Analysis of Bell 1 (Bel 1) mutant ovules indicated that BEL1 was required for integument development. Cloning of the BEL1 locus reveals that it ...

journal_title：Cell

authors： Reiser L,Modrusan Z,Margossian L,Samach A,Ohad N,Haughn GW,Fischer RL

更新日期：1995-12-01 00:00:00

abstract：:Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...

journal_title：Cell

authors： Pirrotta V

更新日期：2009-03-20 00:00:00

abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...

journal_title：Cell

authors： Rhoades MW,Reinhart BJ,Lim LP,Burge CB,Bartel B,Bartel DP

更新日期：2002-08-23 00:00:00

abstract：:Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...

journal_title：Cell

authors： Sanders SL,Whitfield KM,Vogel JP,Rose MD,Schekman RW

更新日期：1992-04-17 00:00:00

abstract：:The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA is surface exposed and exported from bacterial cells. Outer-membrane vesicles (OMVs) released from the bacteria were shown...

journal_title：Cell

authors： Wai SN,Lindmark B,Söderblom T,Takade A,Westermark M,Oscarsson J,Jass J,Richter-Dahlfors A,Mizunoe Y,Uhlin BE

更新日期：2003-10-03 00:00:00

abstract：:We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...

journal_title：Cell

authors： Van Arsdell SW,Denison RA,Bernstein LB,Weiner AM,Manser T,Gesteland RF

更新日期：1981-10-01 00:00:00

abstract：:The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...

journal_title：Cell

authors： Schluenzen F,Tocilj A,Zarivach R,Harms J,Gluehmann M,Janell D,Bashan A,Bartels H,Agmon I,Franceschi F,Yonath A

更新日期：2000-09-01 00:00:00

abstract：:We have previously cloned lethal(2)giant larvae, a tumor-suppressor gene of Drosophila that normally controls cell proliferation and/or differentiation in the optic centers of the brain and the imaginal discs. Here we describe the structure of the l(2)gl genes as determined by sequencing genomic and cDNA clones. The s...

journal_title：Cell

authors： Jacob L,Opper M,Metzroth B,Phannavong B,Mechler BM

更新日期：1987-07-17 00:00:00

abstract：:We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...

journal_title：Cell

authors： Boer PH,Gray MW

更新日期：1988-11-04 00:00:00

abstract：:Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...

journal_title：Cell

authors： Ma A

更新日期：2007-10-05 00:00:00