Abstract:
:Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and, in this capacity, acts upstream of signaling and gene expression. The structure and number of N-glycans per protein molecule cooperate to regulate lectin binding and thereby the distribution of glycoproteins at the cell surface. Congenital disorders of glycosylation provide insight as extreme hypomorphisms, whereas milder deficiencies may encompass many common chronic conditions, including autoimmunity, metabolic syndrome, and aging.
journal_name
Celljournal_title
Cellauthors
Dennis JW,Nabi IR,Demetriou Mdoi
10.1016/j.cell.2009.12.008subject
Has Abstractpub_date
2009-12-24 00:00:00pages
1229-41issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(09)01555-4journal_volume
139pub_type
杂志文章,评审相关文献
CELL文献大全abstract::The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis. We report here that Swe1, the...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.05.029
更新日期:2005-08-12 00:00:00
abstract::Linear simian virus 40 (SV40) chromosomes were prepared by Eco R1 nuclease cleavage of the circular SV40 chromosomes released from virions with dithiothreitol at pH 9,8. Chromatin-DNA hybrids were constructed with segments of 3H-labeled, naked SV40 DNA covalently joined via the Eco R1-generated cohesive ends to segmen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90279-9
更新日期:1978-11-01 00:00:00
abstract::Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.06.023
更新日期:2019-08-08 00:00:00
abstract::Hybrids between mouse hepatoma cells (which secrete several serum proteins) and mouse or rat fibroblasts (which do not secrete these proteins) produce transferrin and the third component of complement (C3) like the parental hepatoma cells, while they do not secrete either albumin or alpha-fetoprotein (AFP). This lack ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90073-2
更新日期:1975-09-01 00:00:00
abstract::In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase. These threads are thought to be catenated centromeric DNA. PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores and...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2006.12.022
更新日期:2007-01-12 00:00:00
abstract::Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.07.038
更新日期:2019-08-22 00:00:00
abstract::Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA polymerase II or III is repressed or not, dependent only on the gene's chromosomal location. Two prevailing models exist for silencing: (1) steric hindrance in silenced chromatin inhibits the binding of upstream activator proteins or...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.11.030
更新日期:2005-01-14 00:00:00
abstract::Frequent codirectional collisions between the replisome and RNA polymerase (RNAP) are inevitable because the rate of replication is much faster than that of transcription. Here we show that, in E. coli, the outcome of such collisions depends on the productive state of transcription elongation complexes (ECs). Codirect...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.07.034
更新日期:2011-08-19 00:00:00
abstract::We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90597-6
更新日期:1992-11-13 00:00:00
abstract::Animal cells can change shape and move by using actin polymerization to drive plasma membrane protrusion. Giannone and coworkers (this issue of Cell) describe how cells periodically pull back on these protrusions in order to sense and respond to the rigidity of their environment. ...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s0092-8674(04)00123-0
更新日期:2004-02-06 00:00:00
abstract::Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-asso...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2008.02.016
更新日期:2008-03-07 00:00:00
abstract::In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2006.01.022
更新日期:2006-02-10 00:00:00
abstract::We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81029-6
更新日期:1996-02-23 00:00:00
abstract::Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90393-s
更新日期:1990-09-21 00:00:00
abstract::Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90179-4
更新日期:1983-12-01 00:00:00
abstract::Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90012-2
更新日期:1987-10-09 00:00:00
abstract::Independently derived mutants of Chinese hamster ovary cells have been isolated and shown to exhibit a subtle glycosylation defect resulting in the premature termination of certain asparagine-linked carbohydrate moieties. This carbohydrate alteration is akin to the types of structural variation termed microheterogenei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90440-2
更新日期:1981-03-01 00:00:00
abstract::Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90142-2
更新日期:1994-06-17 00:00:00
abstract::The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.03.007
更新日期:2005-05-20 00:00:00
abstract::The transcriptional induction of heat shock genes is mediated by the heat shock transcription factor (HSF). We have investigated the oligomerization state of HSF from S. cerevisiae and find that it forms a trimer in solution and when bound to DNA. Trimerization is mediated by a region of HSF that, like the leucine zip...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90604-1
更新日期:1989-12-01 00:00:00
abstract::Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.028
更新日期:2015-09-10 00:00:00
abstract::N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognize...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.014
更新日期:2015-06-04 00:00:00
abstract::Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these "silent" mutations frequently contribute to human cancer. Selection on synonymous mutations in oncogenes is cancer-type specific, and although the functional consequenc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.051
更新日期:2014-03-13 00:00:00
abstract::Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90021-0
更新日期:1976-02-01 00:00:00
abstract::Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2019.01.027
更新日期:2019-02-07 00:00:00
abstract::Cultured hippocampal neurons were infected with a temperature-sensitive mutant of vesicular stomatitis virus (VSV) and a wild-type strain of the avian influenza fowl plague virus (FPV). The intracellular distribution of viral glycoproteins was monitored by immunofluorescence microscopy. In mature, fully polarized neur...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90240-f
更新日期:1990-07-13 00:00:00
abstract::We can maximize the impact of scientific conferences by uploading all conference presentations, posters, and abstracts to highly trafficked public repositories for each content type. Talks can be hosted on sites like YouTube and Youku, posters can be published on Figshare, and papers and abstracts can become open acce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.07.029
更新日期:2020-09-03 00:00:00
abstract::In contrast to uninfected chicken embryo fibroblasts (CEFs), CEFs infected with a retroviral vector that carries the v-erbA gene of avian erythroblastosis virus displayed new properties. These included limited anchorage-independent growth in soft agar, growth without latency in serum-supplemented medium, ability to ov...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90545-9
更新日期:1987-06-05 00:00:00
abstract::The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. There have been conflicting reports on the question of whether p53 posttranslational modifications, such as phosphory...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.03.025
更新日期:2008-05-16 00:00:00
abstract::The proportion of BFU-E normally engaged in DNA synthesis is low in adult B6 (C57BL/6) mice of genotype Fv2rr (resistant to Friend erythroleukemia virus), as shown by 3H-thymidine or hydroxyurea "cell suicide" experiments in vivo and vitro. When bone marrow cells from these mice were subjected to a single wash in alph...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90306-8
更新日期:1981-10-01 00:00:00