Abstract：
:Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-associated molecule (Crtam).
journal_name
Celljournal_title
Cellauthors
Dustin MLdoi
10.1016/j.cell.2008.02.016subject
Has Abstractpub_date
2008-03-07 00:00:00pages
733-4issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(08)00264-Xjournal_volume
132pub_type
评论,杂志文章相关文献
CELL文献大全abstract：:MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.04.059
更新日期：2009-05-15 00:00:00
abstract：:Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.12.039
更新日期：2009-03-06 00:00:00
abstract：:Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation interme...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2014.10.005
更新日期：2014-10-23 00:00:00
abstract：:The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely nee...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.023
更新日期：2014-04-10 00:00:00
abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90268-3
更新日期：1981-01-01 00:00:00
abstract：:Mutants in bacterial topoisomerase (topo) IV are deficient in chromosomal partitioning. To investigate the basis of this phenotype, we examined plasmid DNA topology in conditionally lethal topo IV mutants. We found that dimeric catenated plasmids accumulated in vivo after topo IV inhibition. The catenanes were superco...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90356-h
更新日期：1992-10-16 00:00:00
abstract：:Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00753-5
更新日期：2002-05-31 00:00:00
abstract：:In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the intestine. In this study, we identify and analyze genes required for germline removal to extend life span. We find that the reproductive system communicates with...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.01.039
更新日期：2006-03-10 00:00:00
abstract：:Constitutive egress of bone marrow (BM)-resident hematopoietic stem and progenitor cells (HSPCs) into the blood is a well-established phenomenon, but the ultimate fate and functional relevance of circulating HSPCs is largely unknown. We show that mouse thoracic duct (TD) lymph contains HSPCs that possess short- and lo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.09.047
更新日期：2007-11-30 00:00:00
abstract：:Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis....
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2010.03.033
更新日期：2010-04-16 00:00:00
abstract：:The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.04.006
更新日期：2015-04-23 00:00:00
abstract：:Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte biology, glucose and insulin homeostasis. Despite increased obesi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.09.050
更新日期：2011-11-11 00:00:00
abstract：:Micronuclei of Tetrahymena thermophila contain two electrophoretically distinct forms of histone H3. The slower migrating micronuclear species, H3S, is indistinguishable from the macronuclear H3 by electrophoretic analyses in three gel systems and by partial proteolytic peptide mapping. The faster species, H3F, is uni...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90234-2
更新日期：1980-05-01 00:00:00
abstract：:We have used confocal videomicroscopy in real time to delineate the adhesive interactions supporting platelet thrombus formation on biologically relevant surfaces. Type I collagen fibrils exposed to flowing blood adsorb von Willebrand factor (vWF), to which platelets become initially tethered with continuous surface t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81607-4
更新日期：1998-09-04 00:00:00
abstract：:Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.01.007
更新日期：2020-02-20 00:00:00
abstract：:Two independent approaches to understanding the molecular mechanism of cytokinesis have converged on the gene spaghetti-squash (sqh). A genetic screen for mitotic mutants identified sqh1, a mutation that disrupts cytokinesis, which was then cloned by transposon tagging. Independently, the gene that encodes the regulat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90013-o
更新日期：1991-06-28 00:00:00
abstract：:Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90201-5
更新日期：1978-02-01 00:00:00
abstract：:Vaccinia virus recombinants were generated which express the intact gp70/p15E of Friend mink cell focus inducing virus (F-MCFV) or truncated forms of the glycoprotein that lack the transmembrane and cytoplasmic domains. The transport of the intact and truncated envelope glycoproteins to apical or basolateral surfaces ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90820-2
更新日期：1986-12-26 00:00:00
abstract：:The tumor suppressor gene p53 regulates multiple cellular responses to DNA damage, but the transcriptional targets that specify these responses are incompletely understood. We describe a Drosophila p53 homolog and demonstrate that it can activate transcription from a promoter containing binding sites for human p53. Do...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/S0092-8674(00)80627-3
更新日期：2000-03-31 00:00:00
abstract：:In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly brain to release Drosophila insulin-like peptides (Dilps). Dilp secretion in turn regulates energy balance and promotes system...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.08.019
更新日期：2012-09-28 00:00:00
abstract：:As these paired Commentaries discuss, neuroscientists and architects are just beginning to collaborate, each bringing what they know about their respective fields to the task of improving the environment of research buildings and laboratories. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.10.012
更新日期：2006-10-20 00:00:00
abstract：:Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90696-c
更新日期：1990-06-29 00:00:00
abstract：:Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity (ZPA) is the primary determinant of anterior-posterior polarity in the vertebrate limb field. An active signal is produced by an autoprocessing reaction that covalently links cholesterol to the N-terminal signaling moiety (N-Shh(p)), tetheri...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00369-5
更新日期：2001-06-01 00:00:00
abstract：:Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of thei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.025
更新日期：2020-05-28 00:00:00
abstract：:Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA polymerase II or III is repressed or not, dependent only on the gene's chromosomal location. Two prevailing models exist for silencing: (1) steric hindrance in silenced chromatin inhibits the binding of upstream activator proteins or...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.030
更新日期：2005-01-14 00:00:00
abstract：:The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.039
更新日期：2018-11-15 00:00:00
abstract：:Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...
journal_title：Cell
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.cell.2016.11.008
更新日期：2016-12-01 00:00:00
abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.007
更新日期：2005-05-20 00:00:00
abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.05.049
更新日期：2014-07-31 00:00:00
abstract：:We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90077-2
更新日期：1995-05-19 00:00:00
