Abstract：
:In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the intestine. In this study, we identify and analyze genes required for germline removal to extend life span. We find that the reproductive system communicates with the intestine through lipophilic-hormone signaling and that a gene called kri-1 is likely to act in the intestine to promote DAF-16 nuclear localization in response to this signal. This lipophilic-signaling pathway and kri-1 are not required for DAF-16's nuclear localization and life-span extension in animals with decreased insulin/IGF-1 signaling. Thus, this pathway specifically enables the integration of cues from the reproductive system with central DAF-16-activation pathways to influence the aging of the animal.
journal_name
Celljournal_title
Cellauthors
Berman JR,Kenyon Cdoi
10.1016/j.cell.2006.01.039subject
Has Abstractpub_date
2006-03-10 00:00:00pages
1055-68issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(06)00237-6journal_volume
124pub_type
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