Abstract:
:We explored how the odor map in the Drosophila antennal lobe is represented in higher olfactory centers, the mushroom body and lateral horn. Systematic single-cell tracing of projection neurons (PNs) that send dendrites to specific glomeruli in the antennal lobe revealed their stereotypical axon branching patterns and terminal fields in the lateral horn. PNs with similar axon terminal fields tend to receive input from neighboring glomeruli. The glomerular classes of individual PNs could be accurately predicted based solely on their axon projection patterns. The sum of these patterns defines an "axon map" in higher olfactory centers reflecting which olfactory receptors provide input. This map is characterized by spatial convergence and divergence of PN axons, allowing integration of olfactory information.
journal_name
Celljournal_title
Cellauthors
Marin EC,Jefferis GS,Komiyama T,Zhu H,Luo Ldoi
10.1016/s0092-8674(02)00700-6subject
Has Abstractpub_date
2002-04-19 00:00:00pages
243-55issue
2eissn
0092-8674issn
1097-4172pii
S0092867402007006journal_volume
109pub_type
杂志文章相关文献
CELL文献大全abstract::Replication of Escherichia coli plasmid p15A was examined by use of a cell extract or a mixture of three purified E. coli enzymes: RNA polymerase; RNAase H; and DNA polymerase I. In each system, replication initiates at any of three consecutive nucleotides located at a unique site. Primer transcription starts 508 bp u...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90502-0
更新日期:1983-01-01 00:00:00
abstract::The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.11.039
更新日期:2007-01-12 00:00:00
abstract::Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00632-3
更新日期:2002-02-08 00:00:00
abstract::We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81002-8
更新日期:1996-01-12 00:00:00
abstract::Angiogenesis is an important event for embryonic organogenesis as well as for tissue repair in the adult. Here, we show that hematopoietic stem cells (HSCs) play important roles for angiogenesis during embryogenesis. To investigate the role of HSCs in endothelial cell (EC) development, we analyzed AML1-deficient embry...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00025-8
更新日期:2000-07-21 00:00:00
abstract::Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90624-8
更新日期:1980-06-01 00:00:00
abstract::Liddle's syndrome is an inherited form of hypertension caused by mutations that truncate the C-terminus of human epithelial Na+ channel (hENaC) subunits. Expression of truncated beta and gamma hENaC subunits increased Na+ current. However, truncation did not alter single-channel conductance or open state probability, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90212-0
更新日期:1995-12-15 00:00:00
abstract::We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90313-1
更新日期:1994-04-22 00:00:00
abstract::We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90050-3
更新日期:1979-10-01 00:00:00
abstract::How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have bee...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.024
更新日期:2015-09-10 00:00:00
abstract::Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.07.038
更新日期:2019-08-22 00:00:00
abstract::Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.11.041
更新日期:2004-12-29 00:00:00
abstract::Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in s...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2005.03.019
更新日期:2005-04-08 00:00:00
abstract::Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2020.03.003
更新日期:2020-04-02 00:00:00
abstract::We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90484-5
更新日期:1980-09-01 00:00:00
abstract::To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiv...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.04.043
更新日期:2010-05-14 00:00:00
abstract::In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a bar...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cell.2006.05.016
更新日期:2006-06-02 00:00:00
abstract::Primary cell cultures of African Green monkey kidney (AGMK) contain polarized epithelial cells in which influenza virus matures predominantly at the apical surfaces above tight junctions. Influenza virus glycoproteins were found to be localized at the same membrane domain from which the virus budded. When polarized pr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90425-7
更新日期:1983-06-01 00:00:00
abstract::We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80920-4
更新日期:1998-01-23 00:00:00
abstract::Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90248-3
更新日期:1982-09-01 00:00:00
abstract::Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon et al., 2002). To r...
journal_title:Cell
pub_type: 信件
doi:10.1016/j.cell.2005.08.018
更新日期:2005-10-07 00:00:00
abstract::The state and organization of viral DNA sequences present in independently isolated rat cell lines transformed with SV40 were investigated using restriction-enzyme cleavage of the cellular DNA and blot hybridization with a viral probe. The transformed lines were established under conditions as identical as possible, e...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90569-3
更新日期:1980-12-01 00:00:00
abstract::Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Coupling of cell ancestry information with other molecular readouts represents an important goal in the field. Here, we describe the CRISPR array repair lineage tracing (CARLIN) mouse line and corresponding analysis ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.04.048
更新日期:2020-06-11 00:00:00
abstract::Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.047
更新日期:2017-06-29 00:00:00
abstract::To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they la...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81829-2
更新日期:1996-12-27 00:00:00
abstract::Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of the D-loop region. This part of the mammalian mitochondrial genome is known to contain the origin of heavy strand DNA synthesis and the major transcriptional p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90434-3
更新日期:1984-07-01 00:00:00
abstract::Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution requires understan...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.01.027
更新日期:2015-02-12 00:00:00
abstract::Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal tempo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.08.045
更新日期:2006-10-20 00:00:00
abstract::The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.03.023
更新日期:2007-05-04 00:00:00
abstract::In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly brain to release Drosophila insulin-like peptides (Dilps). Dilp secretion in turn regulates energy balance and promotes system...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.08.019
更新日期:2012-09-28 00:00:00