Abstract:
:Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).
journal_name
Celljournal_title
Cellauthors
Deitsch KWdoi
10.1016/j.cell.2005.03.019subject
Has Abstractpub_date
2005-04-08 00:00:00pages
1-2issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00291-6journal_volume
121pub_type
评论,杂志文章相关文献
CELL文献大全abstract::VopL is an effector protein from Vibrio parahaemolyticus that nucleates actin filaments. VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs. Here, we report the crystal structure of the VCD dimer bound to actin. The VCD organizes three actin monomers in a spatial arrange...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.09.019
更新日期:2013-10-10 00:00:00
abstract::Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.11.025
更新日期:2012-01-20 00:00:00
abstract::We have analyzed two mutations of the white-eye gene, which arose in flies subject to I-R hybrid dysgenesis. These mutations are associated with insertions of apparently identical 5.4 kb sequences, which we have cloned. We believe that these insertions are copies of the I factor controlling I-R hybrid dysgenesis. The ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90536-1
更新日期:1984-08-01 00:00:00
abstract::The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.014
更新日期:2017-05-18 00:00:00
abstract::TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(03)00432-x
更新日期:2003-06-13 00:00:00
abstract::Rodent cells resistant to PALA, a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional CAD protein, overproduce CAD as a result of amplification of the CAD gene. We cloned a functional CAD gene from Syrian hamster cells using a cosmid vector. Two independently isolated cosmids containin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90410-4
更新日期:1981-12-01 00:00:00
abstract::Independently derived mutants of Chinese hamster ovary cells have been isolated and shown to exhibit a subtle glycosylation defect resulting in the premature termination of certain asparagine-linked carbohydrate moieties. This carbohydrate alteration is akin to the types of structural variation termed microheterogenei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90440-2
更新日期:1981-03-01 00:00:00
abstract::We have located the distal boundary of the tyrosine kinase domain of the EGF receptor and have identified a distinct sequence in the C' terminus required for EGF-dependent receptor internalization, leading to receptor down-regulation and degradation. Within this receptor domain, an 18 amino acid highly negatively char...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90867-2
更新日期:1989-10-06 00:00:00
abstract::Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infecti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.030
更新日期:2017-08-24 00:00:00
abstract::Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90051-x
更新日期:1978-12-01 00:00:00
abstract::The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90710-5
更新日期:1986-09-26 00:00:00
abstract::Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birt...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.052
更新日期:2014-08-14 00:00:00
abstract::Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90189-0
更新日期:1975-11-01 00:00:00
abstract::Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autopha...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.05.008
更新日期:2010-06-25 00:00:00
abstract::Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.05.054
更新日期:2013-06-20 00:00:00
abstract::The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00262-8
更新日期:2001-03-09 00:00:00
abstract::Insertion/deletion (IDL) mismatches in DNA are lesions consisting of extra bases on one strand. Here, the binding of p53 and its 14 kDa C-terminal domain to DNAs containing one or three 3-cytosine IDL mismatches was examined. Electron microscopy showed that both p53 forms bound predominantly as tetramers at the lesion...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(05)80006-6
更新日期:1995-06-30 00:00:00
abstract::Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermedia...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00817-6
更新日期:2002-07-12 00:00:00
abstract::Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress granule formation, RNA biology, and neurodegenerative disease. To understand the endogenous function of this protein, we identify Pbp1 as a dedicated regulator of TORC1 signaling an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.02.043
更新日期:2019-04-18 00:00:00
abstract::Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80712-6
更新日期:1999-04-02 00:00:00
abstract::The Ion gene of E. coli controls the stability of two bacteriophage lambda proteins. The functional half-life of the phage N gene product, measured by complementation, is increased about 5-fold in Ion mutant strains, from 2 min to 10 min. The chemical half-life of N protein, determined by its disappearance on polyacry...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90518-3
更新日期:1981-04-01 00:00:00
abstract::Five single base pair mutations that increase expression of the tnpA (transposase) gene of the Tn3 transposon approximately 30-fold, but which still allow the gene to be regulated, have been isolated by using a generally applicable procedure that involves distally linked lac gene fusions. The mutations, which are all ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90352-x
更新日期:1982-02-01 00:00:00
abstract::The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(88)90389-3
更新日期:1988-06-17 00:00:00
abstract::In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for ge...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2012.11.032
更新日期:2012-12-07 00:00:00
abstract::One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90364-5
更新日期:1991-11-29 00:00:00
abstract::The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of vascular morphogenesis. EphrinB2 may have an active signaling role, resulting in bi-directional signal transduction downstream of both ephrinB2 and Eph receptors. To separate the ligand and receptor-like functio...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00191-x
更新日期:2001-01-12 00:00:00
abstract::Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.061
更新日期:2014-03-13 00:00:00
abstract::Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.050
更新日期:2014-07-17 00:00:00
abstract::The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. There have been conflicting reports on the question of whether p53 posttranslational modifications, such as phosphory...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.03.025
更新日期:2008-05-16 00:00:00
abstract::Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90238-8
更新日期:1987-02-27 00:00:00