SnapShot: Nucleo-cytoskeletal Interactions.

abstract：:Addition of LETS glycoprotein to normal or transformed cells produces increased migration of the cells, as determined by formation of phagokinetic tracks on gold particle-coated coverslips. These tracks arise by a combination of phagocytosis of the gold particles and cellular migration. Increased motility is also evid...

journal_title：Cell

authors： Ali IU,Hynes RO

更新日期：1978-06-01 00:00:00

abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...

journal_title：Cell

authors： Harford AG,Zuchowski CI

更新日期：1977-06-01 00:00:00

abstract：:The C-terminal domain (CTD) of the largest subunit of yeast RNA polymerase II contains 26-27 tandem copies of a conserved heptapeptide of unknown function. Yeast strains whose CTD contains ten heptamers are viable but defective for transcription of the INO1 gene and cold sensitive for growth. Deletion of the SIN1 gene...

journal_title：Cell

authors： Peterson CL,Kruger W,Herskowitz I

更新日期：1991-03-22 00:00:00

abstract：:Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...

journal_title：Cell

authors： Rhim AD,Mirek ET,Aiello NM,Maitra A,Bailey JM,McAllister F,Reichert M,Beatty GL,Rustgi AK,Vonderheide RH,Leach SD,Stanger BZ

更新日期：2012-01-20 00:00:00

abstract：:The synthesis of histones and DNA was examined in BHK cells arrested in G1 by isoleucine starvation and in cells progressing into the S phase upon isoleucine refeeding. Approximately 2-3% of the cells were not arrested in G1 and synthesized DNA. The rate of synthesis of DNA and nucleosomal histones observed in cells s...

journal_title：Cell

authors： Tarnowka MA,Baglioni C,Basilico C

更新日期：1978-09-01 00:00:00

abstract：:The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The consequence of this mutation is the substitution of the carboxy-terminal 4...

journal_title：Cell

authors： Kleyn PW,Fan W,Kovats SG,Lee JJ,Pulido JC,Wu Y,Berkemeier LR,Misumi DJ,Holmgren L,Charlat O,Woolf EA,Tayber O,Brody T,Shu P,Hawkins F,Kennedy B,Baldini L,Ebeling C,Alperin GD,Deeds J,Lakey ND,Culpepper J,Chen

更新日期：1996-04-19 00:00:00

abstract：:When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...

journal_title：Cell

authors： Green MR,Treisman R,Maniatis T

更新日期：1983-11-01 00:00:00

abstract：:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...

journal_title：Cell

authors： Colicos MA,Collins BE,Sailor MJ,Goda Y

更新日期：2001-11-30 00:00:00

abstract：:Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...

journal_title：Cell

authors： Forman BM,Goode E,Chen J,Oro AE,Bradley DJ,Perlmann T,Noonan DJ,Burka LT,McMorris T,Lamph WW,Evans RM,Weinberger C

更新日期：1995-06-02 00:00:00

abstract：:We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...

journal_title：Cell

authors： Pitt GS,Milona N,Borleis J,Lin KC,Reed RR,Devreotes PN

更新日期：1992-04-17 00:00:00

abstract：:Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from red...

journal_title：Cell

authors： Yan L,Vatner DE,O'Connor JP,Ivessa A,Ge H,Chen W,Hirotani S,Ishikawa Y,Sadoshima J,Vatner SF

更新日期：2007-07-27 00:00:00

abstract：:During development, distinct classes of neurons are specified in precise locations along the dorso-ventral and anterior-posterior axes of the neural tube. We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary a...

journal_title：Cell

authors： Ye W,Shimamura K,Rubenstein JL,Hynes MA,Rosenthal A

更新日期：1998-05-29 00:00:00

abstract：:To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited myeloid lineage expansion, lymphoid developmental abnormalities, and a marked decrease of the lineage-negative Sca-1+, c-Kit+ (LSK) compartme...

journal_title：Cell

authors： Tothova Z,Kollipara R,Huntly BJ,Lee BH,Castrillon DH,Cullen DE,McDowell EP,Lazo-Kallanian S,Williams IR,Sears C,Armstrong SA,Passegué E,DePinho RA,Gilliland DG

更新日期：2007-01-26 00:00:00

abstract：:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...

journal_title：Cell

authors： Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R

更新日期：1987-08-14 00:00:00

abstract：:Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We u...

journal_title：Cell

authors： Shah PS,Link N,Jang GM,Sharp PP,Zhu T,Swaney DL,Johnson JR,Von Dollen J,Ramage HR,Satkamp L,Newton B,Hüttenhain R,Petit MJ,Baum T,Everitt A,Laufman O,Tassetto M,Shales M,Stevenson E,Iglesias GN,Shokat L,Tripathi

更新日期：2018-12-13 00:00:00

abstract：:Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicit...

journal_title：Cell

authors： Tuganbaev T,Mor U,Bashiardes S,Liwinski T,Nobs SP,Leshem A,Dori-Bachash M,Thaiss CA,Pinker EY,Ratiner K,Adlung L,Federici S,Kleimeyer C,Moresi C,Yamada T,Cohen Y,Zhang X,Massalha H,Massasa E,Kuperman Y,Koni PA,H

更新日期：2020-09-17 00:00:00

abstract：:Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...

journal_title：Cell

authors： Sharabi K,Lin H,Tavares CDJ,Dominy JE,Camporez JP,Perry RJ,Schilling R,Rines AK,Lee J,Hickey M,Bennion M,Palmer M,Nag PP,Bittker JA,Perez J,Jedrychowski MP,Ozcan U,Gygi SP,Kamenecka TM,Shulman GI,Schreiber SL,Gr

更新日期：2017-03-23 00:00:00

abstract：:Removal of histone H1 produces a transition in the structure of chromatin fibers as observed by electron microscopy. Chromatin containing all histone proteins appears as fibers with a diameter of about 250 A. The nucleosomes within these fibers are closely packed. If histone H1 is selectively removed with 50-100 mM Na...

journal_title：Cell

authors： Thoma F,Koller T

更新日期：1977-09-01 00:00:00

abstract：:The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...

journal_title：Cell

authors： Marmorstein R

更新日期：2003-11-14 00:00:00

abstract：:Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the...

journal_title：Cell

authors： Salmena L,Poliseno L,Tay Y,Kats L,Pandolfi PP

更新日期：2011-08-05 00:00:00

abstract：:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...

journal_title：Cell

authors： Müller U,Wang D,Denda S,Meneses JJ,Pedersen RA,Reichardt LF

更新日期：1997-03-07 00:00:00

abstract：:Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for transcription termination. Pausing and termination states are thought to arise through a common, elemental pause state that is inhibitory for nu...

journal_title：Cell

authors： Weixlbaumer A,Leon K,Landick R,Darst SA

更新日期：2013-01-31 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induce...

journal_title：Cell

authors： Kenny B,DeVinney R,Stein M,Reinscheid DJ,Frey EA,Finlay BB

更新日期：1997-11-14 00:00:00

abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...

journal_title：Cell

authors： Shirayoshi Y,Okada TS,Takeichi M

更新日期：1983-12-01 00:00:00

abstract：:During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...

journal_title：Cell

authors： Hussain T,Llácer JL,Fernández IS,Munoz A,Martin-Marcos P,Savva CG,Lorsch JR,Hinnebusch AG,Ramakrishnan V

更新日期：2014-10-23 00:00:00

abstract：:Three-dimensional structures of a native simian and reassortant rotavirus have been determined by electron cryomicroscopy and computer image processing. The structural features of the native virus confirm that the hemagglutinin spike is a dimer of VP4, substantiated by in vivo radiolabeling studies. Exchange of native...

journal_title：Cell

authors： Shaw AL,Rothnagel R,Chen D,Ramig RF,Chiu W,Prasad BV

更新日期：1993-08-27 00:00:00

abstract：:An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...

journal_title：Cell

authors： Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jin

更新日期：2013-02-14 00:00:00

abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...

journal_title：Cell

authors： Leyton L,Saling P

更新日期：1989-06-30 00:00:00

abstract：:We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlled chicken MyoD cDNA, r...

journal_title：Cell

authors： Peterson CA,Gordon H,Hall ZW,Paterson BM,Blau HM

更新日期：1990-08-10 00:00:00

abstract：:A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphoryl...

journal_title：Cell

authors： Ginty DD,Bonni A,Greenberg ME

更新日期：1994-06-03 00:00:00