SnapShot: Nucleo-cytoskeletal Interactions.


:The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration.






Janota CS,Calero-Cuenca FJ,Costa J,Gomes ER




Has Abstract


2017-05-18 00:00:00
















  • Cellular memory and the histone code.

    abstract::The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications that may, singly or in combination, form a code specifying patterns of gene expression. Recent papers provide insights into how a combinatorial code might be set and read. They show how modification of one residue can influence t...


    pub_type: 评论,杂志文章,评审


    authors: Turner BM

    更新日期:2002-11-01 00:00:00

  • Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes.

    abstract::Genomic Xenopus borealis oocyte-specific 5S DNA (Xbo) contains clusters of 5S rRNA genes. The number of genes varies among clusters, and the distance between genes within a cluster is about 80 nucleotides. The spacer DNA between gene clusters is AT-rich and heterogeneous in length due in part to variable numbers of a ...


    pub_type: 杂志文章


    authors: Korn LJ,Brown DD

    更新日期:1978-12-01 00:00:00

  • A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis.

    abstract::New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to pro...


    pub_type: 杂志文章


    authors: Berg DA,Su Y,Jimenez-Cyrus D,Patel A,Huang N,Morizet D,Lee S,Shah R,Ringeling FR,Jain R,Epstein JA,Wu QF,Canzar S,Ming GL,Song H,Bond AM

    更新日期:2019-04-18 00:00:00

  • The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break.

    abstract::The Mre11/Rad50 complex has been implicated in the early steps of DNA double-strand break (DSB) repair through homologous recombination in several organisms. However, the enzymatic properties of this complex are incompatible with the generation of 3' single-stranded DNA for recombinase loading and strand exchange. In ...


    pub_type: 杂志文章


    authors: Hopkins BB,Paull TT

    更新日期:2008-10-17 00:00:00

  • A secondary attachment site for bacteriophage lambda in trpC of E. coli.

    abstract::We have determined the nucleotide sequence of a secondary lambda attachment site in trpC. Direct sequence analysis of lambdatrp transducing phage DNA fragments carrying the two prophage attachment sites reveals a 6 nucleotide homology in the crossover region which is a subset of the 15 nucleotide core sequence in the ...


    pub_type: 杂志文章


    authors: Christie GE,Platt T

    更新日期:1979-02-01 00:00:00

  • Calmodulin-induced early-onset diabetes in transgenic mice.

    abstract::Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...


    pub_type: 杂志文章


    authors: Epstein PN,Overbeek PA,Means AR

    更新日期:1989-09-22 00:00:00

  • Identification and mapping of the transcriptional and translational products of the yeast plasmid, 2mu circle.

    abstract::We have identified two major and approximately ten minor poly(A)-containing RNA species in S. cerevisiae which arise from in vivo transcription of the yeast plasmid, known as 2mu circle. The two major species, which are 1325 and 1275 bases in length, are transcribed from the two unique halves of the plasmid and extend...


    pub_type: 杂志文章


    authors: Broach JR,Atkins JF,McGill C,Chow L

    更新日期:1979-04-01 00:00:00

  • Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.

    abstract::A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...


    pub_type: 杂志文章


    authors: Davies AA,Neiss A,Ulrich HD

    更新日期:2010-06-11 00:00:00

  • Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.

    abstract::Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic doma...


    pub_type: 杂志文章


    authors: Min J,Feng Q,Li Z,Zhang Y,Xu RM

    更新日期:2003-03-07 00:00:00

  • Detection of a subunit of cellular Pol II within highly purified preparations of RNA polymerase isolated from rabbit poxvirus virions.

    abstract::A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Followin...


    pub_type: 杂志文章


    authors: Morrison DK,Moyer RW

    更新日期:1986-02-28 00:00:00

  • In vitro transcription and processing of a yeast tRNA gene containing an intervening sequence.

    abstract::A gene for Saccharomyces cerevisiae tRNATrp has been sequenced which contains an intervening sequence of 34 bp (H. S. Kang and J. Abelson, unpublished results). The mutant yeast strain ts-136 accumulates a precursor to tRNATrp which contains mature ends and is colinear with the tRNATrp gene. A nuclear extract from Xen...


    pub_type: 杂志文章


    authors: Ogden RC,Beckman JS,Abelson J,Kang HS,Söll D,Schmidt O

    更新日期:1979-06-01 00:00:00

  • High level expression of the Activator transposase gene inhibits the excision of Dissociation in tobacco cotyledons.

    abstract::A fusion of the strong cauliflower mosaic virus 35S promoter to the Activator (Ac) transposase (TPASE) gene does not trigger excision of Dissociation (Ds) continuously during tobacco cotyledon development, although once activated, the 35S promoter remains active throughout embryogeny. Epistasis studies where 35S:TPASE...


    pub_type: 杂志文章


    authors: Scofield SR,English JJ,Jones JD

    更新日期:1993-11-05 00:00:00

  • Immunogenic structure of the influenza virus hemagglutinin.

    abstract::We chemically synthesized 20 peptides corresponding to 75% of the HA1 molecule of the influenza virus. Antibodies to the majority (18) of these peptides were capable of reacting with the hemagglutinin molecule. These 18 peptides are not confined to the known antigenic determinants of the hemagglutinin molecule, but ra...


    pub_type: 杂志文章


    authors: Green N,Alexander H,Olson A,Alexander S,Shinnick TM,Sutcliffe JG,Lerner RA

    更新日期:1982-03-01 00:00:00

  • Identification of a nuclear receptor that is activated by farnesol metabolites.

    abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...


    pub_type: 杂志文章


    authors: Forman BM,Goode E,Chen J,Oro AE,Bradley DJ,Perlmann T,Noonan DJ,Burka LT,McMorris T,Lamph WW,Evans RM,Weinberger C

    更新日期:1995-06-02 00:00:00

  • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

    abstract::Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...


    pub_type: 杂志文章


    authors: Greenwell PW,Kronmal SL,Porter SE,Gassenhuber J,Obermaier B,Petes TD

    更新日期:1995-09-08 00:00:00

  • Mutant PTEN in Cancer: Worse Than Nothing.

    abstract::Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...


    pub_type: 评论,杂志文章


    authors: Leslie NR,den Hertog J

    更新日期:2014-04-24 00:00:00

  • Evidence for in vivo trans splicing of pre-mRNAs in tobacco chloroplasts.

    abstract::The rps12 gene codes for chloroplast ribosomal protein S12. In the tobacco chloroplast genome (156 kbp circular DNA), exons II and III of this gene are separated by an intron of 536 bases and are present in two copies in the inverted repeat region, while exon I is located in the large single copy region at a distance ...


    pub_type: 杂志文章


    authors: Koller B,Fromm H,Galun E,Edelman M

    更新日期:1987-01-16 00:00:00

  • Lighting up the stressed ER.

    abstract::Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...


    pub_type: 评论,杂志文章


    authors: Kang SW,Hegde RS

    更新日期:2008-11-28 00:00:00

  • Polycomb repression under the skin.

    abstract::Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...


    pub_type: 评论,杂志文章


    authors: Pirrotta V

    更新日期:2009-03-20 00:00:00

  • Organoid models of human and mouse ductal pancreatic cancer.

    abstract::Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...


    pub_type: 杂志文章


    authors: Boj SF,Hwang CI,Baker LA,Chio II,Engle DD,Corbo V,Jager M,Ponz-Sarvise M,Tiriac H,Spector MS,Gracanin A,Oni T,Yu KH,van Boxtel R,Huch M,Rivera KD,Wilson JP,Feigin ME,Öhlund D,Handly-Santana A,Ardito-Abraham CM,L

    更新日期:2015-01-15 00:00:00

  • Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.

    abstract::Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...


    pub_type: 杂志文章


    authors: Hudson LG,Santon JB,Glass CK,Gill GN

    更新日期:1990-09-21 00:00:00

  • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

    abstract::The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteocl...


    pub_type: 杂志文章


    authors: Lacey DL,Timms E,Tan HL,Kelley MJ,Dunstan CR,Burgess T,Elliott R,Colombero A,Elliott G,Scully S,Hsu H,Sullivan J,Hawkins N,Davy E,Capparelli C,Eli A,Qian YX,Kaufman S,Sarosi I,Shalhoub V,Senaldi G,Guo J,Delane

    更新日期:1998-04-17 00:00:00

  • A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

    abstract::Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...


    pub_type: 杂志文章


    authors: Alpatov R,Lesch BJ,Nakamoto-Kinoshita M,Blanco A,Chen S,Stützer A,Armache KJ,Simon MD,Xu C,Ali M,Murn J,Prisic S,Kutateladze TG,Vakoc CR,Min J,Kingston RE,Fischle W,Warren ST,Page DC,Shi Y

    更新日期:2014-05-08 00:00:00

  • Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.

    abstract::During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...


    pub_type: 杂志文章


    authors: Baker CC,Herisse J,Courtois G,Galibert F,Ziff E

    更新日期:1979-10-01 00:00:00

  • Evidence for a common evolutionary origin of inverted repeat transposons in Drosophila and plants: hobo, Activator, and Tam3.

    abstract::We have sequenced HFL1 from D. melanogaster, the only cloned hobo element shown to have transposase activity. The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum ma...


    pub_type: 杂志文章


    authors: Calvi BR,Hong TJ,Findley SD,Gelbart WM

    更新日期:1991-08-09 00:00:00

  • Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation.

    abstract::The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...


    pub_type: 杂志文章


    authors: Shaw AC,Mitchell RN,Weaver YK,Campos-Torres J,Abbas AK,Leder P

    更新日期:1990-10-19 00:00:00

  • Viral RNAs: lessons from the enemy.

    abstract::Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I...


    pub_type: 杂志文章


    authors: Cullen BR

    更新日期:2009-02-20 00:00:00

  • A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis.

    abstract::Transfection experiments with HSV 1 in which one uses herpes simplex virus (HSV) thymidine kinase (TK) as a selectable prototrophic marker yield two classes of transformed cells: stable and unstable. In this report, we test the hypothesis that the stability phenotype can be explained by virus genome integration into a...


    pub_type: 杂志文章


    authors: Smiley JR,Steege DA,Juricek DK,Summers WP,Ruddle FH

    更新日期:1978-10-01 00:00:00

  • Transfer of murine intracisternal A particle phenotype in chloramphenicol-resistant cytoplasts.

    abstract::Murine intracisternal A particles have a number of properties which are common to known RNA tumor viruses, but horizontal transmission has not been previously demonstrated. The apparent absence of infectivity may be related to the failure of these particles to be released from cisternae of endo-plasmic reticulum. Prev...


    pub_type: 杂志文章


    authors: Malech HL,Wivel NA

    更新日期:1976-11-01 00:00:00

  • A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity.

    abstract::Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (delta FosB) missing the C-terminal 101 amino acids of FosB. delta FosB retains the dimerization and DNA-binding acti...


    pub_type: 杂志文章


    authors: Nakabeppu Y,Nathans D

    更新日期:1991-02-22 00:00:00