Abstract：
:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP-actin at individual synapses. A single tetanus transiently moves presynaptic actin toward and postsynaptic actin away from the synaptic junction. Repetitive spaced tetani induce glutamate receptor-dependent stable restructuring of synapses. Presynaptic actin redistributes and forms new puncta that label for an active synapse marker FM5-95 within 2 hr. Postsynaptic actin sprouts projections toward the new presynaptic actin puncta, resembling the axon-dendrite interaction during synaptogenesis. Our results indicate that activity-dependent presynaptic structural plasticity facilitates the formation of new active presynaptic terminals.
journal_name
Celljournal_title
Cellauthors
Colicos MA,Collins BE,Sailor MJ,Goda Ydoi
10.1016/s0092-8674(01)00579-7subject
Has Abstractpub_date
2001-11-30 00:00:00pages
605-16issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00579-7journal_volume
107pub_type
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