Abstract:
:Adult skeletal muscle generates force in a controlled and directed manner through the contraction of highly specialized, postmitotic, multinucleated myofibers. Life-long muscle function relies on maintenance and regeneration of myofibers through a highly regulated process beginning with activation of normally quiescent muscle precursor cells and proceeding with formation of proliferating progenitors that fuse to generate differentiated myofibers. In this review, we describe the historical basis and current evidence for the identification of satellite cells as adult muscle stem cells, critically evaluate contributions of other cells to adult myogenesis, and summarize existing data regarding the origins, genetic markers, and molecular regulation of satellite cells in normal, diseased, and aged muscle.
journal_name
Celljournal_title
Cellauthors
Wagers AJ,Conboy IMdoi
10.1016/j.cell.2005.08.021subject
Has Abstractpub_date
2005-09-09 00:00:00pages
659-67issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00858-5journal_volume
122pub_type
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