当前位置： SCI文献检索 > CELL期刊下所有文献 > ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.

Abstract：

:Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we report the purification of ARIA, a protein that stimulates the synthesis of muscle acetylcholine receptors, and the isolation of ARIA cDNA. Recombinant ARIA increases acetylcholine receptor synthesis greater than 3-fold, and it induces tyrosine phosphorylation of a 185 kd muscle protein. The ARIA cDNA hybridizes with mRNAs that are expressed in the spinal cord from E4, a time prior to the onset of neuromuscular synapse formation, through adulthood. By E7, hybridizing mRNAs are concentrated in motor neurons. Chicken ARIA is homologous to the rat Neu differentiation factor and human here-gulin, ligands for the receptor tyrosine kinase encoded by the neu (c-erbB2, HER2) proto-oncogene. Our data suggest that members of the ARIA protein family promote the formation and maintenance of chemical synapses and, furthermore, that receptor tyrosine kinases play important roles in this process.

journal_name

Cell

journal_title

Cell

authors

Falls DL,Rosen KM,Corfas G,Lane WS,Fischbach GD

doi

10.1016/0092-8674(93)90407-h

subject

Has Abstract

pub_date

1993-03-12 00:00:00

pages

801-15

issue

5

eissn

0092-8674

issn

1097-4172

pii

0092-8674(93)90407-H

journal_volume

72

pub_type

杂志文章

相关文献

CELL文献大全
  • The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.

    abstract：:Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.05.071

    authors： Long JZ,Svensson KJ,Bateman LA,Lin H,Kamenecka T,Lokurkar IA,Lou J,Rao RR,Chang MR,Jedrychowski MP,Paulo JA,Gygi SP,Griffin PR,Nomura DK,Spiegelman BM

    更新日期：2016-07-14 00:00:00

  • Abate and switch: miR-145 in stem cell differentiation.

    abstract：:MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2009.04.059

    authors： Chivukula RR,Mendell JT

    更新日期：2009-05-15 00:00:00

  • A Call for Systematic Research on Solute Carriers.

    abstract：:Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of s...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2015.07.022

    authors： César-Razquin A,Snijder B,Frappier-Brinton T,Isserlin R,Gyimesi G,Bai X,Reithmeier RA,Hepworth D,Hediger MA,Edwards AM,Superti-Furga G

    更新日期：2015-07-30 00:00:00

  • Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.

    abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2005.09.041

    authors： Ohtsubo K,Takamatsu S,Minowa MT,Yoshida A,Takeuchi M,Marth JD

    更新日期：2005-12-29 00:00:00

  • The initiation of SV40 DNA synthesis is not unique to the replication origin.

    abstract：:Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(80)90624-8

    authors： Martin RG,Setlow VP

    更新日期：1980-06-01 00:00:00

  • Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

    abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2014.05.049

    authors： Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis I

    更新日期：2014-07-31 00:00:00

  • Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif.

    abstract：:We have adopted Drosophila tissue culture cells as a host system for studying the structure and function of mammalian transcription factors. These cells provide an Sp1-deficient background and have been used in a complementation assay to identify functional domains of human transcription factor Sp1. The SV40 early pro...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(88)90144-4

    authors： Courey AJ,Tjian R

    更新日期：1988-12-02 00:00:00

  • Going Public in Support of Science.

    abstract：:Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.03.029

    authors： Matheson S

    更新日期：2017-04-06 00:00:00

  • Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

    abstract：:A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T cell line has been identified using a mammalian cell expression cloning system. The sequence of this cDNA proved to have significant homology to the sequence encoding murine interleukin 3 (IL-3). The human gene, which was readily...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90360-0

    authors： Yang YC,Ciarletta AB,Temple PA,Chung MP,Kovacic S,Witek-Giannotti JS,Leary AC,Kriz R,Donahue RE,Wong GG

    更新日期：1986-10-10 00:00:00

  • A nonpolymorphic class I gene in the murine major histocompatibility complex.

    abstract：:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide produc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(84)90082-5

    authors： Mellor AL,Weiss EH,Kress M,Jay G,Flavell RA

    更新日期：1984-01-01 00:00:00

  • A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.

    abstract：:Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.10.014

    authors： Han J,Zhang H,Zhang H,Wang Z,Zhou H,Zhang Z

    更新日期：2013-11-07 00:00:00

  • Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome.

    abstract：:We have isolated and characterized several members of the P transposable element family from a Drosophila melanogaster P strain. Large 2.9 kb elements are present as multiple highly conserved copies together with smaller (0.5-1.6 kb), heterogeneous elements. The complete DNA sequences of the 2.9 kb element and four sm...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90133-2

    authors： O'Hare K,Rubin GM

    更新日期：1983-08-01 00:00:00

  • Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro.

    abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(85)90216-8

    authors： Simon M,Green H

    更新日期：1985-03-01 00:00:00

  • Fruit fly family fun.

    abstract：:A recent comparative analysis of the sequenced genomes of 12 Drosophila species (Drosophila 12 Genomes Consortium, 2007; Stark et al., 2007) reveals a comprehensive picture of the evolution of small animal genomes and greatly improves computational predictions of functional elements in the D. melanogaster reference se...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.12.003

    authors： Sidow A,Lacroute P

    更新日期：2007-12-28 00:00:00

  • Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.

    abstract：:We report the discovery of a short-lived chaperone that is required for the correct maturation of the eukaryotic 20S proteasome and is destroyed at a specific stage of the assembly process. The S. cerevisiae Ump1p protein is a component of proteasome precursor complexes containing unprocessed beta subunits but is not ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80942-3

    authors： Ramos PC,Höckendorff J,Johnson ES,Varshavsky A,Dohmen RJ

    更新日期：1998-02-20 00:00:00

  • The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.

    abstract：:The Xist gene maps to the X inactivation center region in both mouse and human, and previous analysis of the 3' end of the gene has demonstrated inactive X-specific expression, suggesting a possible role in X inactivation. We have now analyzed the entire mouse Xist gene. The mature inactive X-specific transcript is 15...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(92)90519-i

    authors： Brockdorff N,Ashworth A,Kay GF,McCabe VM,Norris DP,Cooper PJ,Swift S,Rastan S

    更新日期：1992-10-30 00:00:00

  • Processive recombination by the phage Mu Gin system: implications for the mechanisms of DNA strand exchange, DNA site alignment, and enhancer action.

    abstract：:The Gin DNA invertase of bacteriophage Mu carries out processive recombination in which multiple rounds of exchange follow synaptic complex formation. The stereostructure of the knotted products determined by electron microscopy establishes critical features of site synapsis and DNA exchange. Surprisingly, the inverta...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90372-l

    authors： Kanaar R,Klippel A,Shekhtman E,Dungan JM,Kahmann R,Cozzarelli NR

    更新日期：1990-07-27 00:00:00

  • A tollgate for typhoid.

    abstract：:Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2012.10.016

    authors： Fang FC,Bäumler AJ

    更新日期：2012-10-26 00:00:00

  • Glucose Metabolism Linked to Antiviral Responses.

    abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2019.05.057

    authors： Stoolman JS,Chandel NS

    更新日期：2019-06-27 00:00:00

  • Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.

    abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90393-s

    authors： Hudson LG,Santon JB,Glass CK,Gill GN

    更新日期：1990-09-21 00:00:00

  • Breaking colinearity in the mouse HoxD complex.

    abstract：:Vertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progress...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80749-7

    authors： Kondo T,Duboule D

    更新日期：1999-04-30 00:00:00

  • Seeking new antibiotics in nature's backyard.

    abstract：:As the pipeline of new antibiotics slows to a trickle, scientists are developing innovative strategies to unearth antibacterial compounds in unexpected places. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.11.021

    authors： von Bubnoff A

    更新日期：2006-12-01 00:00:00

  • Tiki casts a spell on Wnt.

    abstract：:Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2012.06.007

    authors： Vincent JP,Magee T

    更新日期：2012-06-22 00:00:00

  • A study of foldback DNA.

    abstract：:Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(76)90182-3

    authors： Perlman S,Phillips C,Bishop JO

    更新日期：1976-05-01 00:00:00

  • Yeast histone H4 N-terminal sequence is required for promoter activation in vivo.

    abstract：:To search for histone domains that may regulate transcription in vivo, we made deletions and amino acid substitutions in the histone N-termini of S. cerevisiae. Histone H4 N-terminal residues 4-23, which include the extremely conserved, reversibly acetylated lysines (at positions 5, 8, 12, and 16), were found to encom...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(91)90554-c

    authors： Durrin LK,Mann RK,Kayne PS,Grunstein M

    更新日期：1991-06-14 00:00:00

  • Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation.

    abstract：:The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90171-a

    authors： Shaw AC,Mitchell RN,Weaver YK,Campos-Torres J,Abbas AK,Leder P

    更新日期：1990-10-19 00:00:00

  • Posttranscriptional control of T cell effector function by aerobic glycolysis.

    abstract：:A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incomplet...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.05.016

    authors： Chang CH,Curtis JD,Maggi LB Jr,Faubert B,Villarino AV,O'Sullivan D,Huang SC,van der Windt GJ,Blagih J,Qiu J,Weber JD,Pearce EJ,Jones RG,Pearce EL

    更新日期：2013-06-06 00:00:00

  • Doubling Down on Mutant RAS Can MEK or Break Leukemia.

    abstract：:Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.02.013

    authors： Tothova Z,Ebert BL

    更新日期：2017-02-23 00:00:00

  • Organ-level quorum sensing directs regeneration in hair stem cell populations.

    abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.02.016

    authors： Chen CC,Wang L,Plikus MV,Jiang TX,Murray PJ,Ramos R,Guerrero-Juarez CF,Hughes MW,Lee OK,Shi S,Widelitz RB,Lander AD,Chuong CM

    更新日期：2015-04-09 00:00:00

  • Extended self-renewal capacity of pluripotent hemopoietic stem cells: association with persistent Friend spleen focus-forming virus.

    abstract：:The pluripotential hemopoietic stem cells (CFU-S) of genetically resistant Fv2rr adult C57BL/6 (B6) mice can be persistently infected by Friend virus (FV) when exposed to defective spleen focus-forming virus (SFFV) and helper virus (LLV) at the time of transplantation into heavily irradiated syngeneic recipients (that...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(82)90327-0

    authors： Eckner RJ,Hettrick KL,Greenberger JS,Bennett M

    更新日期：1982-12-01 00:00:00