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Breaking colinearity in the mouse HoxD complex.

Abstract：

:Vertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progressively available for transcription in the course of gastrulation, implying the existence of an element capable of initiating a repressive conformation, subsequently relieved from the clusters sequentially. We searched for this element by combining a genomic walk with successive transgene insertions upstream of the HoxD complex followed by a series of deletions. The largest deficiency induced posterior homeotic transformations coincidentally with an earlier activation of Hoxd genes. These data suggest that a regulatory element located upstream of the complex is necessary for setting up the early pattern of Hox gene colinear activation.

journal_name

Cell

journal_title

Cell

authors

Kondo T,Duboule D

doi

10.1016/s0092-8674(00)80749-7

subject

Has Abstract

pub_date

1999-04-30 00:00:00

pages

407-17

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(00)80749-7

journal_volume

97

pub_type

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