A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding.

abstract：:The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...

journal_title：Cell

authors： Church GM,Slonimski PP,Gilbert W

更新日期：1979-12-01 00:00:00

abstract：:In S. cerevisiae, mitochondrial DNA (mtDNA) molecules, in spite of their high copy number, segregate as if there were a small number of heritable units. The rapid segregation of mitochondrial genomes can be analyzed using mtDNA deletion variants. These small, amplified genomes segregate preferentially from mixed zygot...

journal_title：Cell

authors： Lockshon D,Zweifel SG,Freeman-Cook LL,Lorimer HE,Brewer BJ,Fangman WL

更新日期：1995-06-16 00:00:00

abstract：:Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected g...

journal_title：Cell

authors： Niehrs C,Keller R,Cho KW,De Robertis EM

更新日期：1993-02-26 00:00:00

abstract：:The susceptibility to repair of particular base mismatches by the hex system of Streptococcus pneumoniae was examined by comparison of the nucleotide sequence of the wild-type and eight mutant alleles of the malM gene. A detailed restriction map was constructed for pLS70, and the nucleotide sequence was determined for...

journal_title：Cell

authors： Lacks SA,Dunn JJ,Greenberg B

更新日期：1982-12-01 00:00:00

abstract：:A yeast gene homologous to bacterial RNase III (RNT1) encodes a double-strand-specific endoribonuclease essential for ribosome synthesis. Two rRNA processing events are blocked in cells temperature sensitive for RNT1: cleavage at the snoRNA-dependent AO site in the 5' ETS and cleavage in the 3' ETS. Recombinant RNT1 p...

journal_title：Cell

authors： Elela SA,Igel H,Ares M Jr

更新日期：1996-04-05 00:00:00

abstract：:Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors ...

journal_title：Cell

authors： Yang BX,El Farran CA,Guo HC,Yu T,Fang HT,Wang HF,Schlesinger S,Seah YF,Goh GY,Neo SP,Li Y,Lorincz MC,Tergaonkar V,Lim TM,Chen L,Gunaratne J,Collins JJ,Goff SP,Daley GQ,Li H,Bard FA,Loh YH

更新日期：2015-09-24 00:00:00

abstract：:Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal tempo...

journal_title：Cell

authors： Zhu S,Lin S,Kao CF,Awasaki T,Chiang AS,Lee T

更新日期：2006-10-20 00:00:00

abstract：:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously...

journal_title：Cell

authors： Abeliovich A,Paylor R,Chen C,Kim JJ,Wehner JM,Tonegawa S

更新日期：1993-12-31 00:00:00

abstract：:Six restriction fragments of Ad2 DNA which contain sites for RNA initiation have been identified by their ability to hybridize nascent labeled RNA less than 1 kb in length. Four RNA initiation sites early in infection are identified in regions where previous work (Flint, 1977) had mapped mRNAs. The major late RNA init...

journal_title：Cell

authors： Evans RM,Fraser N,Ziff E,Weber J,Wilson M,Darnell JE

更新日期：1977-11-01 00:00:00

abstract：:We have developed a cell-free system for studying the integration of retroviral DNA. In our assay, amber mutations in a bacteriophage lambda genome that serves as the target for integration are suppressed by integration of an MLV derivative that carries the E. coli supF gene. The structure of the reaction products is ...

journal_title：Cell

authors： Brown PO,Bowerman B,Varmus HE,Bishop JM

更新日期：1987-05-08 00:00:00

abstract：:Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...

journal_title：Cell

authors： Sanders SL,Whitfield KM,Vogel JP,Rose MD,Schekman RW

更新日期：1992-04-17 00:00:00

abstract：:Removal of histone H1 produces a transition in the structure of chromatin fibers as observed by electron microscopy. Chromatin containing all histone proteins appears as fibers with a diameter of about 250 A. The nucleosomes within these fibers are closely packed. If histone H1 is selectively removed with 50-100 mM Na...

journal_title：Cell

authors： Thoma F,Koller T

更新日期：1977-09-01 00:00:00

abstract：:Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot. ...

journal_title：Cell

authors： Bonekamp NA,Larsson NG

更新日期：2018-01-11 00:00:00

abstract：:Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...

journal_title：Cell

authors： Liu J,Lee J,Salazar Hernandez MA,Mazitschek R,Ozcan U

更新日期：2015-05-21 00:00:00

abstract：:Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA...

journal_title：Cell

authors： Piper DE,Batchelor AH,Chang CP,Cleary ML,Wolberger C

更新日期：1999-02-19 00:00:00

abstract：:Three-dimensional structures of a native simian and reassortant rotavirus have been determined by electron cryomicroscopy and computer image processing. The structural features of the native virus confirm that the hemagglutinin spike is a dimer of VP4, substantiated by in vivo radiolabeling studies. Exchange of native...

journal_title：Cell

authors： Shaw AL,Rothnagel R,Chen D,Ramig RF,Chiu W,Prasad BV

更新日期：1993-08-27 00:00:00

abstract：:New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PR...

journal_title：Cell

authors： Burslem GM,Crews CM

更新日期：2020-04-02 00:00:00

abstract：:Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...

journal_title：Cell

authors： Bartlett TM,Bratton BP,Duvshani A,Miguel A,Sheng Y,Martin NR,Nguyen JP,Persat A,Desmarais SM,VanNieuwenhze MS,Huang KC,Zhu J,Shaevitz JW,Gitai Z

更新日期：2017-01-12 00:00:00

abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...

journal_title：Cell

authors： Stock J,Kersulis G,Koshland DE Jr

更新日期：1985-09-01 00:00:00

abstract：:Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on...

journal_title：Cell

authors： Armstrong JA,Bieker JJ,Emerson BM

更新日期：1998-10-02 00:00:00

abstract：:The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...

journal_title：Cell

authors： Reith W,Satola S,Sanchez CH,Amaldi I,Lisowska-Grospierre B,Griscelli C,Hadam MR,Mach B

更新日期：1988-06-17 00:00:00

abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...

journal_title：Cell

authors： Ogata K,Morikawa S,Nakamura H,Sekikawa A,Inoue T,Kanai H,Sarai A,Ishii S,Nishimura Y

更新日期：1994-11-18 00:00:00

abstract：:We have adopted Drosophila tissue culture cells as a host system for studying the structure and function of mammalian transcription factors. These cells provide an Sp1-deficient background and have been used in a complementation assay to identify functional domains of human transcription factor Sp1. The SV40 early pro...

journal_title：Cell

authors： Courey AJ,Tjian R

更新日期：1988-12-02 00:00:00

abstract：:A gene for Saccharomyces cerevisiae tRNATrp has been sequenced which contains an intervening sequence of 34 bp (H. S. Kang and J. Abelson, unpublished results). The mutant yeast strain ts-136 accumulates a precursor to tRNATrp which contains mature ends and is colinear with the tRNATrp gene. A nuclear extract from Xen...

journal_title：Cell

authors： Ogden RC,Beckman JS,Abelson J,Kang HS,Söll D,Schmidt O

更新日期：1979-06-01 00:00:00

abstract：:Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...

journal_title：Cell

authors： Chevalier C,Stojanović O,Colin DJ,Suarez-Zamorano N,Tarallo V,Veyrat-Durebex C,Rigo D,Fabbiano S,Stevanović A,Hagemann S,Montet X,Seimbille Y,Zamboni N,Hapfelmeier S,Trajkovski M

更新日期：2015-12-03 00:00:00

abstract：:A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

journal_title：Cell

authors： Gaul U,Mardon G,Rubin GM

更新日期：1992-03-20 00:00:00

abstract：:Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...

journal_title：Cell

authors： Bonetta L

更新日期：2009-10-30 00:00:00

abstract：:Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...

journal_title：Cell

authors： Ojakian GK

更新日期：1981-01-01 00:00:00

abstract：:DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found t...

journal_title：Cell

authors： Sutendra G,Kinnaird A,Dromparis P,Paulin R,Stenson TH,Haromy A,Hashimoto K,Zhang N,Flaim E,Michelakis ED

更新日期：2014-07-03 00:00:00

abstract：:CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi...

journal_title：Cell

authors： Zheng W,Flavell RA

更新日期：1997-05-16 00:00:00