Abstract:
:New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PROTAC technology and its application to drug discovery and provide examples where PROTACs have enabled novel biological insights. Furthermore, we provide a workflow for PROTAC development and use and discuss the benefits and issues associated with PROTACs. Finally, we compare PROTAC-mediated protein-level modulation with other technologies, such as RNAi and genome editing.
journal_name
Celljournal_title
Cellauthors
Burslem GM,Crews CMdoi
10.1016/j.cell.2019.11.031subject
Has Abstractpub_date
2020-04-02 00:00:00pages
102-114issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(19)31316-9journal_volume
181pub_type
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