"Cloaking" on Time: A Cover-Up Act by Resident Tissue Macrophages.

Abstract:

:In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.

journal_name

Cell

journal_title

Cell

authors

Blériot C,Ng LG,Ginhoux F

doi

10.1016/j.cell.2019.03.042

subject

Has Abstract

pub_date

2019-04-18 00:00:00

pages

514-516

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(19)30343-5

journal_volume

177

pub_type

评论,杂志文章

相关文献

CELL文献大全
  • Histone variants specific to the transcriptionally active, amitotically dividing macronucleus of the unicellular eucaryote, Tetrahymena thermophila.

    abstract::Two dimensional gel electrophoresis (triton-acid-urea followed by SDS) has been used to resolve two previously uncharacterized, quantitatively minor histone variants in acid extracts from macronuclei of Tetrahymena thermophila. Utilizing techniques which allow characterization of these variants without purifying them ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(80)90307-4

    authors: Allis CD,Glover CV,Bowen JK,Gorovsky MA

    更新日期:1980-07-01 00:00:00

  • The structure of the human histone genes: clustered but not tandemly repeated.

    abstract::We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90092-1

    authors: Heintz N,Zernik M,Roeder RG

    更新日期:1981-06-01 00:00:00

  • Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel.

    abstract::Liddle's syndrome is an inherited form of hypertension caused by mutations that truncate the C-terminus of human epithelial Na+ channel (hENaC) subunits. Expression of truncated beta and gamma hENaC subunits increased Na+ current. However, truncation did not alter single-channel conductance or open state probability, ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90212-0

    authors: Snyder PM,Price MP,McDonald FJ,Adams CM,Volk KA,Zeiher BG,Stokes JB,Welsh MJ

    更新日期:1995-12-15 00:00:00

  • Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.

    abstract::In this report, we describe the isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific markers. Myogenin is absent in undifferentiated cells, p...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(89)90583-7

    authors: Wright WE,Sassoon DA,Lin VK

    更新日期:1989-02-24 00:00:00

  • Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy.

    abstract::Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(94)90142-2

    authors: Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

    更新日期:1994-06-17 00:00:00

  • Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic.

    abstract::The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.07.018

    authors: Grubaugh ND,Saraf S,Gangavarapu K,Watts A,Tan AL,Oidtman RJ,Ladner JT,Oliveira G,Matteson NL,Kraemer MUG,Vogels CBF,Hentoff A,Bhatia D,Stanek D,Scott B,Landis V,Stryker I,Cone MR,Kopp EW 4th,Cannons AC,Heberlein-L

    更新日期:2019-08-22 00:00:00

  • Novel inheritance of the murine severe combined anemia and thrombocytopenia (Scat) phenotype.

    abstract::The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)90301-6

    authors: Peters LL,Barker JE

    更新日期:1993-07-16 00:00:00

  • The structure and regulation of human muscle α-actinin.

    abstract::The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large protein complexes involved in structural integrity and mechanosensation, as well as cell signaling. α-actinins in particular are t...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2014.10.056

    authors: Ribeiro Ede A Jr,Pinotsis N,Ghisleni A,Salmazo A,Konarev PV,Kostan J,Sjöblom B,Schreiner C,Polyansky AA,Gkougkoulia EA,Holt MR,Aachmann FL,Zagrović B,Bordignon E,Pirker KF,Svergun DI,Gautel M,Djinović-Carugo K

    更新日期:2014-12-04 00:00:00

  • Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity.

    abstract::Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81615-3

    authors: Sen J,Goltz JS,Stevens L,Stein D

    更新日期:1998-11-13 00:00:00

  • Lifted Up from Lockdown.

    abstract::The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among colleagues, collaborators, and competitors; and significant democ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2020.09.027

    authors: Arturo EC,Saphire EO

    更新日期:2020-10-01 00:00:00

  • Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.

    abstract::In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized interactions capable of orchestrating complex cellular functions. Visualizing these interactions requires noninvasive, long-duration imaging of the intracellular environment at high spatiotemporal resolution and low background. T...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.09.057

    authors: Guo Y,Li D,Zhang S,Yang Y,Liu JJ,Wang X,Liu C,Milkie DE,Moore RP,Tulu US,Kiehart DP,Hu J,Lippincott-Schwartz J,Betzig E,Li D

    更新日期:2018-11-15 00:00:00

  • An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.

    abstract::A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(85)90174-6

    authors: Carthew RW,Chodosh LA,Sharp PA

    更新日期:1985-12-01 00:00:00

  • X inactivation of the OCNC1 channel gene reveals a role for activity-dependent competition in the olfactory system.

    abstract::The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(01)00262-8

    authors: Zhao H,Reed RR

    更新日期:2001-03-09 00:00:00

  • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

    abstract::The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2010.10.032

    authors: Victora GD,Schwickert TA,Fooksman DR,Kamphorst AO,Meyer-Hermann M,Dustin ML,Nussenzweig MC

    更新日期:2010-11-12 00:00:00

  • Calorie restriction--the SIR2 connection.

    abstract::A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast a...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2005.01.029

    authors: Guarente L,Picard F

    更新日期:2005-02-25 00:00:00

  • Treatment of obesity with celastrol.

    abstract::Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2015.05.011

    authors: Liu J,Lee J,Salazar Hernandez MA,Mazitschek R,Ozcan U

    更新日期:2015-05-21 00:00:00

  • Progressive loss of shape-responsive metabolic controls in cells with increasingly transformed phenotype.

    abstract::The modulation of cell metabolism by cell shape and external surface contact has been studied by suspension culture of anchorage-dependent fibroblasts. The suspended cells shut down protein synthesis and nuclear RNA metabolism and cease replicating DNA. However, these responses to suspension are lost or modified as ce...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90111-2

    authors: Wittelsberger SC,Kleene K,Penman S

    更新日期:1981-06-01 00:00:00

  • Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells.

    abstract::Monkey cell lines that constitutively synthesize 38.6 kd lac repressor protein and bear stably integrated chloramphenicol acetyl transferase (CAT) genes linked to a lac operator-containing SV40 early promoter-enhancer were generated. When grown in medium containing isopropyl beta-D-thiogalactoside (IPTG), these cells ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90409-6

    authors: Figge J,Wright C,Collins CJ,Roberts TM,Livingston DM

    更新日期:1988-03-11 00:00:00

  • Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex.

    abstract::Telomeres of Oxytricha nova macronuclear chromosomes consist of a repeated T4G4 sequence, single-stranded at the 3' terminus, bound by a heterodimeric protein. The cloning of genes for the two polypeptides and their separate expression in E. coli have enabled evaluation of their individual contributions to DNA binding...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(91)90075-a

    authors: Gray JT,Celander DW,Price CM,Cech TR

    更新日期:1991-11-15 00:00:00

  • 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

    abstract::Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribo...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.07.034

    authors: Zid BM,Rogers AN,Katewa SD,Vargas MA,Kolipinski MC,Lu TA,Benzer S,Kapahi P

    更新日期:2009-10-02 00:00:00

  • Viral RNAs: lessons from the enemy.

    abstract::Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.01.048

    authors: Cullen BR

    更新日期:2009-02-20 00:00:00

  • Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

    abstract::Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have dev...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2017.09.021

    authors: Stockwell BR,Friedmann Angeli JP,Bayir H,Bush AI,Conrad M,Dixon SJ,Fulda S,Gascón S,Hatzios SK,Kagan VE,Noel K,Jiang X,Linkermann A,Murphy ME,Overholtzer M,Oyagi A,Pagnussat GC,Park J,Ran Q,Rosenfeld CS,Salnikow K

    更新日期:2017-10-05 00:00:00

  • The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.

    abstract::Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this dupli...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.02.046

    authors: Shum EY,Jones SH,Shao A,Dumdie J,Krause MD,Chan WK,Lou CH,Espinoza JL,Song HW,Phan MH,Ramaiah M,Huang L,McCarrey JR,Peterson KJ,De Rooij DG,Cook-Andersen H,Wilkinson MF

    更新日期:2016-04-07 00:00:00

  • Chaperone activity with a redox switch.

    abstract::Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80547-4

    authors: Jakob U,Muse W,Eser M,Bardwell JC

    更新日期:1999-02-05 00:00:00

  • Alpha-amanitin-resistant D. melanogaster with an altered RNA polymerase II.

    abstract::Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(79)90116-8

    authors: Greenleaf AL,Borsett LM,Jiamachello PF,Coulter DE

    更新日期:1979-11-01 00:00:00

  • E. coli and M. luteus DNA topoisomerase I can catalyze catenation of decatenation of double-stranded DNA rings.

    abstract::Escherichia coli and Micrococcus luteus DNA topoisomerase I are found to promote catenation of double-stranded DNA rings. At low DNA concentration dimeric catenanes are the major catenated products; at high DNA concentration or when spermidine is present, catenanes containing more than two rings are formed. There is n...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(80)90174-9

    authors: Tse Y,Wang JC

    更新日期:1980-11-01 00:00:00

  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

    abstract::Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/S0092-8674(00)80605-4

    authors: Wang J,Zheng L,Lobito A,Chan FK,Dale J,Sneller M,Yao X,Puck JM,Straus SE,Lenardo MJ

    更新日期:1999-07-09 00:00:00

  • Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.

    abstract::The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)90424-o

    authors: Struhl G,Fitzgerald K,Greenwald I

    更新日期:1993-07-30 00:00:00

  • Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.

    abstract::Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80662-5

    authors: Piper DE,Batchelor AH,Chang CP,Cleary ML,Wolberger C

    更新日期:1999-02-19 00:00:00

  • SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.

    abstract::The light-sensing organelle of the vertebrate rod photoreceptor, the outer segment (OS), is a modified cilium containing approximately 1,000 stacked disc membranes that are densely packed with visual pigment rhodopsin. The mammalian OS is renewed every ten days; new discs are assembled at the base of the OS by a poorl...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2007.06.030

    authors: Chuang JZ,Zhao Y,Sung CH

    更新日期:2007-08-10 00:00:00