"Cloaking" on Time: A Cover-Up Act by Resident Tissue Macrophages.


:In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.






Blériot C,Ng LG,Ginhoux F




Has Abstract


2019-04-18 00:00:00
















  • The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction.

    abstract::The 50 amino acid form of TGF-alpha is cleaved from a conserved integral membrane glycoprotein by a protease that, in many tumor cells, appears to be limiting. To test whether the membrane-bound precursor has biological activity in the absence of processing, we introduced amino acid substitutions at the proteolytic cl...


    pub_type: 杂志文章


    authors: Wong ST,Winchell LF,McCune BK,Earp HS,Teixidó J,Massagué J,Herman B,Lee DC

    更新日期:1989-02-10 00:00:00

  • Conformational changes in a replication origin induced by an initiator protein.

    abstract::The replication initiator protein of the plasmid R6K binds to seven contiguous 22 bp direct repeats that form an indispensable part of the three replication origins alpha, beta, and gamma. Binding of the initiator to the direct repeats induced a marked bending of the region of gamma replication origin. Binding of the ...


    pub_type: 杂志文章


    authors: Mukherjee S,Patel I,Bastia D

    更新日期:1985-11-01 00:00:00

  • Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.

    abstract::Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...


    pub_type: 杂志文章


    authors: Schwayer C,Shamipour S,Pranjic-Ferscha K,Schauer A,Balda M,Tada M,Matter K,Heisenberg CP

    更新日期:2019-10-31 00:00:00

  • Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration.

    abstract::Portions of the nascent chain are exposed to the lumen, the cytosol, or neither at different stages during the cotranslational integration of a protein into the ER membrane, as shown by compartment-specific collisional quenching of fluorophores incorporated into the polypeptide. The opening or closing of each end of t...


    pub_type: 杂志文章


    authors: Liao S,Lin J,Do H,Johnson AE

    更新日期:1997-07-11 00:00:00

  • Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs.

    abstract::Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...


    pub_type: 杂志文章


    authors: Mukherji A,Kobiita A,Ye T,Chambon P

    更新日期:2013-05-09 00:00:00

  • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.

    abstract::I have identified an activity in crude HeLa cell extracts that satisfies the requirements for a human telomere terminal transferase or telomerase. It catalyzes the addition of a 6 nucleotide repeating pattern to oligonucleotide primers containing human or nonhuman telomeric repeat sequences. Direct sequence analyses o...


    pub_type: 杂志文章


    authors: Morin GB

    更新日期:1989-11-03 00:00:00

  • A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.

    abstract::Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here, we describe a peptide toxin from the Earth Tiger tarantula that selectively and irreversibly activates the c...


    pub_type: 杂志文章


    authors: Bohlen CJ,Priel A,Zhou S,King D,Siemens J,Julius D

    更新日期:2010-05-28 00:00:00

  • Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals.

    abstract::The commitment complex is the first defined step in the yeast (S. cerevisiae) splicing pathway. It contains U1 snRNP as well as Mud2p, which resembles human U2AF65. In a genetic screen, we identified the yeast gene MSL-5, which is a novel commitment complex component. Genetic and biochemical criteria indicate a direct...


    pub_type: 杂志文章


    authors: Abovich N,Rosbash M

    更新日期:1997-05-02 00:00:00

  • Structural Insights into the Process of GPCR-G Protein Complex Formation.

    abstract::The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...


    pub_type: 杂志文章


    authors: Liu X,Xu X,Hilger D,Aschauer P,Tiemann JKS,Du Y,Liu H,Hirata K,Sun X,Guixà-González R,Mathiesen JM,Hildebrand PW,Kobilka BK

    更新日期:2019-05-16 00:00:00

  • A study of foldback DNA.

    abstract::Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...


    pub_type: 杂志文章


    authors: Perlman S,Phillips C,Bishop JO

    更新日期:1976-05-01 00:00:00

  • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein.

    abstract::Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed i...


    pub_type: 杂志文章


    authors: Schaffer JE,Lodish HF

    更新日期:1994-11-04 00:00:00

  • An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.

    abstract::A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...


    pub_type: 杂志文章


    authors: Carthew RW,Chodosh LA,Sharp PA

    更新日期:1985-12-01 00:00:00

  • A Drosophila model for xeroderma pigmentosum and Cockayne's syndrome: haywire encodes the fly homolog of ERCC3, a human excision repair gene.

    abstract::The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS). XP is a human autosomal recessive disease characterized by extreme sensitivity to ultraviolet irradiation and marked susceptibility to ...


    pub_type: 杂志文章


    authors: Mounkes LC,Jones RS,Liang BC,Gelbart W,Fuller MT

    更新日期:1992-12-11 00:00:00

  • Molecular cloning of cDNA for human von Willebrand factor: authentication by a new method.

    abstract::We have identified a 2.4 kb partial cDNA clone (pDL34) for human von Willebrand factor (vWf) mRNA. pDL34 was selected by screening an endothelial cell cDNA library with a radiolabeled reverse transcript of mRNA obtained by specific immunoisolation of vWf polysomes from endothelial cells. pDL34 selectively hybridized t...


    pub_type: 杂志文章


    authors: Lynch DC,Zimmerman TS,Collins CJ,Brown M,Morin MJ,Ling EH,Livingston DM

    更新日期:1985-05-01 00:00:00

  • Nine introns with conserved boundary sequences in the Euglena gracilis chloroplast ribulose-1,5-bisphosphate carboxylase gene.

    abstract::The single, chloroplast encoded gene for the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) from Euglena gracilis is found to contain nine intervening sequences. The intervening sequences were identified by heteroduplex analysis between Euglena rbcL and the non-intron-containing rbcL from Spin...


    pub_type: 杂志文章


    authors: Koller B,Gingrich JC,Stiegler GL,Farley MA,Delius H,Hallick RB

    更新日期:1984-02-01 00:00:00

  • O2 sensing: only skin deep?

    abstract::The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to ...


    pub_type: 评论,杂志文章


    authors: Semenza GL

    更新日期:2008-04-18 00:00:00

  • The somatic replication of DNA methylation.

    abstract::We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...


    pub_type: 杂志文章


    authors: Wigler M,Levy D,Perucho M

    更新日期:1981-04-01 00:00:00

  • Structural basis of caspase-7 inhibition by XIAP.

    abstract::The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...


    pub_type: 杂志文章


    authors: Chai J,Shiozaki E,Srinivasula SM,Wu Q,Datta P,Alnemri ES,Shi Y

    更新日期:2001-03-09 00:00:00

  • Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.

    abstract::The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from ful...


    pub_type: 杂志文章


    authors: Kalamakis G,Brüne D,Ravichandran S,Bolz J,Fan W,Ziebell F,Stiehl T,Catalá-Martinez F,Kupke J,Zhao S,Llorens-Bobadilla E,Bauer K,Limpert S,Berger B,Christen U,Schmezer P,Mallm JP,Berninger B,Anders S,Del Sol A,Marc

    更新日期:2019-03-07 00:00:00

  • Direct Visualization of Wide Fusion-Fission Pores and Their Highly Varied Dynamics.

    abstract::In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-...


    pub_type: 评论,杂志文章


    authors: Eyring KW,Tsien RW

    更新日期:2018-05-03 00:00:00

  • Regulation of corneal collagenase production: stimulation of serially passaged stromal cells by blood mononuclear cells.

    abstract::After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimul...


    pub_type: 杂志文章


    authors: Newsome DA,Gross J

    更新日期:1979-04-01 00:00:00

  • Optimal Decoding of Cellular Identities in a Genetic Network.

    abstract::In developing organisms, spatially prescribed cell identities are thought to be determined by the expression levels of multiple genes. Quantitative tests of this idea, however, require a theoretical framework capable of exposing the rules and precision of cell specification over developmental time. We use the gap gene...


    pub_type: 杂志文章


    authors: Petkova MD,Tkačik G,Bialek W,Wieschaus EF,Gregor T

    更新日期:2019-02-07 00:00:00

  • A symmetrical six-base-pair target site sequence determines Tn10 insertion specificity.

    abstract::Transposon Tn10 inserts at many sites in the bacterial chromosome, but preferentially inserts at particular hotspots. We believe we have identified the target DNA signal responsible for this specificity. We have determined the DNA sequences of 11 Tn10 insertion sites and identified a particular 6 base pair (bp) symmet...


    pub_type: 杂志文章


    authors: Halling SM,Kleckner N

    更新日期:1982-01-01 00:00:00

  • Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

    abstract::Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue. The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae. We show that Mms2p forms a specific heteromer...


    pub_type: 杂志文章


    authors: Hofmann RM,Pickart CM

    更新日期:1999-03-05 00:00:00

  • Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.

    abstract::An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42 to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously identified components are not sufficient to mediate Cdc42-induced actin polymerization in a physiological context. In this paper, we describe ...


    pub_type: 杂志文章


    authors: Ho HY,Rohatgi R,Lebensohn AM,Le Ma,Li J,Gygi SP,Kirschner MW

    更新日期:2004-07-23 00:00:00

  • Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones.

    abstract::The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...


    pub_type: 杂志文章


    authors: McKnight GS,Hager L,Palmiter RD

    更新日期:1980-11-01 00:00:00

  • Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro.

    abstract::The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...


    pub_type: 杂志文章


    authors: Gilmore T,DeClue JE,Martin GS

    更新日期:1985-03-01 00:00:00

  • Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.

    abstract::Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...


    pub_type: 杂志文章


    authors: Hao LY,Armanios M,Strong MA,Karim B,Feldser DM,Huso D,Greider CW

    更新日期:2005-12-16 00:00:00

  • Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast.

    abstract::Our previous deletion experiments have shown that a short region of yeast nuclear gene introns containing the conserved sequence 5'-TACTAACA-3' is essential for splicing. In this report we show that the chemically synthesized decanucleotide 5'-TGTACTAACA-3', when introduced into a hybrid gene forming unspliceable RNA ...


    pub_type: 杂志文章


    authors: Langford CJ,Klinz FJ,Donath C,Gallwitz D

    更新日期:1984-03-01 00:00:00

  • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

    abstract::Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...


    pub_type: 杂志文章


    authors: Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

    更新日期:2007-03-23 00:00:00