Abstract：
:The Brachyury (T) gene is required for mesoderm formation in the mouse. In this paper we describe the cloning and expression of a Xenopus homolog of Brachyury, Xbra. As with Brachyury in the mouse, Xbra is expressed in presumptive mesodermal cells around the blastopore, and then in the notochord. We show that expression of Xbra occurs as a result of mesoderm induction in Xenopus, both in response to the natural signal and in response to the mesoderm-inducing factors activin A and basic FGF. Expression of Xbra in response to these factors is rapid, and will occur in dispersed cells and in the presence of a protein synthesis inhibitor, indicating that this is an "immediate-early" response to mesoderm induction.
journal_name
Celljournal_title
Cellauthors
Smith JC,Price BM,Green JB,Weigel D,Herrmann BGdoi
10.1016/0092-8674(91)90573-hsubject
Has Abstractpub_date
1991-10-04 00:00:00pages
79-87issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(91)90573-Hjournal_volume
67pub_type
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