A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster.

Abstract:

:The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injection into the abdominal cavity of female virgins. Amino acid sequencing of the purified peptide and oligonucleotide-directed cDNA cloning established that the peptide consists of 36 amino acids. It appears to be synthesized as a precursor with a hydrophobic signal sequence of 19 residues at its N-terminal end. The precursor peptide is encoded by a short mRNA that accumulates exclusively in the male accessory gland. The gene has been localized by in situ hybridization to polytene chromosomes at 70A.

journal_name

Cell

journal_title

Cell

authors

Chen PS,Stumm-Zollinger E,Aigaki T,Balmer J,Bienz M,Böhlen P

doi

10.1016/0092-8674(88)90192-4

subject

Has Abstract

pub_date

1988-07-29 00:00:00

pages

291-8

issue

3

eissn

0092-8674

issn

1097-4172

pii

0092-8674(88)90192-4

journal_volume

54

pub_type

杂志文章

相关文献

CELL文献大全
  • Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

    abstract::Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta cell function and insulin action in peripheral tissues. We identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from t...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2007.12.035

    authors: Chibalin AV,Leng Y,Vieira E,Krook A,Björnholm M,Long YC,Kotova O,Zhong Z,Sakane F,Steiler T,Nylén C,Wang J,Laakso M,Topham MK,Gilbert M,Wallberg-Henriksson H,Zierath JR

    更新日期:2008-02-08 00:00:00

  • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.

    abstract::Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2011.07.039

    authors: Yang Y,Atasoy D,Su HH,Sternson SM

    更新日期:2011-09-16 00:00:00

  • Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.

    abstract::Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen wi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90139-6

    authors: Molkentin JD,Black BL,Martin JF,Olson EN

    更新日期:1995-12-29 00:00:00

  • Alleles of the APC gene: an attenuated form of familial polyposis.

    abstract::An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)90538-2

    authors: Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

    更新日期:1993-12-03 00:00:00

  • Sites of topoisomerase I action on X. laevis ribosomal chromatin: transcriptionally active rDNA has an approximately 200 bp repeating structure.

    abstract::The sites at which topoisomerase I interacts with the transcriptionally active ribosomal chromatin of Xenopus oocytes were mapped by treating oocyte nuclei first with camptothecin to stabilize topoisomerase I-rDNA reaction intermediates, and then with SDS to resolve these adducts as protein-linked nicks in the DNA. St...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90471-0

    authors: Culotta V,Sollner-Webb B

    更新日期:1988-02-26 00:00:00

  • Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

    abstract::Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminat...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(02)00753-5

    authors: Saitoh S,Chabes A,McDonald WH,Thelander L,Yates JR,Russell P

    更新日期:2002-05-31 00:00:00

  • The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.

    abstract::Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this dupli...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.02.046

    authors: Shum EY,Jones SH,Shao A,Dumdie J,Krause MD,Chan WK,Lou CH,Espinoza JL,Song HW,Phan MH,Ramaiah M,Huang L,McCarrey JR,Peterson KJ,De Rooij DG,Cook-Andersen H,Wilkinson MF

    更新日期:2016-04-07 00:00:00

  • High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.

    abstract::Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define differences across all hematopoietic cells from syngeneic mouse tumors during unrestrained ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.09.030

    authors: Gubin MM,Esaulova E,Ward JP,Malkova ON,Runci D,Wong P,Noguchi T,Arthur CD,Meng W,Alspach E,Medrano RFV,Fronick C,Fehlings M,Newell EW,Fulton RS,Sheehan KCF,Oh ST,Schreiber RD,Artyomov MN

    更新日期:2018-11-01 00:00:00

  • Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

    abstract::Adenovirus E1B 19 kDa protein protects against cell death induced by viral infection and certain external stimuli. The Bcl-2 protein can functionally substitute for the E1B 19 kDa protein. To identify cellular targets for the 19 kDa protein, we used the two-hybrid screen in yeast. We have isolated cDNAs for three diff...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(94)90202-x

    authors: Boyd JM,Malstrom S,Subramanian T,Venkatesh LK,Schaeper U,Elangovan B,D'Sa-Eipper C,Chinnadurai G

    更新日期:1994-10-21 00:00:00

  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

    abstract::Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this g...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2012.02.054

    authors: Sparrow DB,Chapman G,Smith AJ,Mattar MZ,Major JA,O'Reilly VC,Saga Y,Zackai EH,Dormans JP,Alman BA,McGregor L,Kageyama R,Kusumi K,Dunwoodie SL

    更新日期:2012-04-13 00:00:00

  • Genetic recombination of homologous plasmids catalyzed by cell-free extracts of Saccharomyces cerevisiae.

    abstract::We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(83)90113-7

    authors: Symington LS,Fogarty LM,Kolodner R

    更新日期:1983-12-01 00:00:00

  • Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

    abstract::Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.02.047

    authors: Ma S,Cahalan S,LaMonte G,Grubaugh ND,Zeng W,Murthy SE,Paytas E,Gamini R,Lukacs V,Whitwam T,Loud M,Lohia R,Berry L,Khan SM,Janse CJ,Bandell M,Schmedt C,Wengelnik K,Su AI,Honore E,Winzeler EA,Andersen KG,Patapou

    更新日期:2018-04-05 00:00:00

  • Isolation and characterization of a serine esterase from cytolytic T cell granules.

    abstract::Cytotoxic T lymphocytes and lymphocytes with NK-like activity contain a serine esterase activity which has been localized to their cytoplasmic granules by cytochemistry and subcellular fractionation studies. The serine esterase-specific inhibitor 3H-DFP labels two protein species in the granules. The two proteins, ref...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90441-1

    authors: Young JD,Leong LG,Liu CC,Damiano A,Wall DA,Cohn ZA

    更新日期:1986-10-24 00:00:00

  • Stabilizing HIF to Ameliorate Anemia.

    abstract::Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chr...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.12.010

    authors: Voit RA,Sankaran VG

    更新日期:2020-01-09 00:00:00

  • Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

    abstract::Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81923-6

    authors: González-Gaitán M,Jäckle H

    更新日期:1997-03-21 00:00:00

  • Alternative splicing accounts for the four forms of myelin basic protein.

    abstract::We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene. The three larger forms of MBP differ from the smallest by the inclusion of either or both of two short amino acid sequences at positions 57 and 124 of the smallest protein...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(85)90245-4

    authors: de Ferra F,Engh H,Hudson L,Kamholz J,Puckett C,Molineaux S,Lazzarini RA

    更新日期:1985-12-01 00:00:00

  • Growth rate-dependent global effects on gene expression in bacteria.

    abstract::Bacterial gene expression depends not only on specific regulatory mechanisms, but also on bacterial growth, because important global parameters such as the abundance of RNA polymerases and ribosomes are all growth-rate dependent. Understanding of these global effects is necessary for a quantitative understanding of ge...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.12.001

    authors: Klumpp S,Zhang Z,Hwa T

    更新日期:2009-12-24 00:00:00

  • Both layers of the COPII coat come into view.

    abstract::Anterograde transport in the early secretory pathway is mediated by COPII-coated vesicles. Stagg et al. (2008) have now visualized the double-layered COPII coat using electron cryomicroscopy, providing insight into how coats are assembled to accommodate cargo of different sizes. ...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2008.07.027

    authors: Hughson FM

    更新日期:2008-08-08 00:00:00

  • Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

    abstract::Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity (ZPA) is the primary determinant of anterior-posterior polarity in the vertebrate limb field. An active signal is produced by an autoprocessing reaction that covalently links cholesterol to the N-terminal signaling moiety (N-Shh(p)), tetheri...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(01)00369-5

    authors: Lewis PM,Dunn MP,McMahon JA,Logan M,Martin JF,St-Jacques B,McMahon AP

    更新日期:2001-06-01 00:00:00

  • T cell susceptibility to HIV influences outcome of opportunistic infections.

    abstract::During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence sus...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.09.045

    authors: Saharia KK,Koup RA

    更新日期:2013-10-24 00:00:00

  • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.

    abstract::The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80255-x

    authors: Taylor SS,McKeon F

    更新日期:1997-05-30 00:00:00

  • Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.

    abstract::Histone acetyltransferases (HATs) and histone deacetylases (HDACs) conduct many critical functions through nonhistone substrates in metazoans, but only chromatin-associated nonhistone substrates are known in Saccharomyces cerevisiae. Using yeast proteome microarrays, we identified and validated many nonchromatin subst...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.01.033

    authors: Lin YY,Lu JY,Zhang J,Walter W,Dang W,Wan J,Tao SC,Qian J,Zhao Y,Boeke JD,Berger SL,Zhu H

    更新日期:2009-03-20 00:00:00

  • A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

    abstract::Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.03.002

    authors: Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR

    更新日期:2017-03-23 00:00:00

  • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

    abstract::SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single posi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80048-3

    authors: Marine JC,Topham DJ,McKay C,Wang D,Parganas E,Stravopodis D,Yoshimura A,Ihle JN

    更新日期:1999-09-03 00:00:00

  • The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

    abstract::NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further reduction in worm lifespan. Conversely, genetic or pharmacological...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.06.016

    authors: Mouchiroud L,Houtkooper RH,Moullan N,Katsyuba E,Ryu D,Cantó C,Mottis A,Jo YS,Viswanathan M,Schoonjans K,Guarente L,Auwerx J

    更新日期:2013-07-18 00:00:00

  • Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation.

    abstract::Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mut...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81964-9

    authors: Koh YH,Popova E,Thomas U,Griffith LC,Budnik V

    更新日期:1999-08-06 00:00:00

  • A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

    abstract::Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80853-3

    authors: Briscoe J,Pierani A,Jessell TM,Ericson J

    更新日期:2000-05-12 00:00:00

  • In vitro transcription and processing of a yeast tRNA gene containing an intervening sequence.

    abstract::A gene for Saccharomyces cerevisiae tRNATrp has been sequenced which contains an intervening sequence of 34 bp (H. S. Kang and J. Abelson, unpublished results). The mutant yeast strain ts-136 accumulates a precursor to tRNATrp which contains mature ends and is colinear with the tRNATrp gene. A nuclear extract from Xen...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(79)90166-1

    authors: Ogden RC,Beckman JS,Abelson J,Kang HS,Söll D,Schmidt O

    更新日期:1979-06-01 00:00:00

  • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

    abstract::Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.12.007

    authors: Pece S,Tosoni D,Confalonieri S,Mazzarol G,Vecchi M,Ronzoni S,Bernard L,Viale G,Pelicci PG,Di Fiore PP

    更新日期:2010-01-08 00:00:00

  • Topological "frustration" in multispanning E. coli inner membrane proteins.

    abstract::The topology of E. coli inner membrane proteins depends primarily on the distribution of positively charged residues in the molecule. We have constructed model proteins with four potential transmembrane stretches and have systematically explored the topological effects of lysines placed in the loops connecting the tra...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(94)90155-4

    authors: Gafvelin G,von Heijne G

    更新日期:1994-05-06 00:00:00