Abstract:
:The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injection into the abdominal cavity of female virgins. Amino acid sequencing of the purified peptide and oligonucleotide-directed cDNA cloning established that the peptide consists of 36 amino acids. It appears to be synthesized as a precursor with a hydrophobic signal sequence of 19 residues at its N-terminal end. The precursor peptide is encoded by a short mRNA that accumulates exclusively in the male accessory gland. The gene has been localized by in situ hybridization to polytene chromosomes at 70A.
journal_name
Celljournal_title
Cellauthors
Chen PS,Stumm-Zollinger E,Aigaki T,Balmer J,Bienz M,Böhlen Pdoi
10.1016/0092-8674(88)90192-4subject
Has Abstractpub_date
1988-07-29 00:00:00pages
291-8issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(88)90192-4journal_volume
54pub_type
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