Seeking new antibiotics in nature's backyard.

abstract：:The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...

journal_title：Cell

authors： Olive KP,Tuveson DA,Ruhe ZC,Yin B,Willis NA,Bronson RT,Crowley D,Jacks T

更新日期：2004-12-17 00:00:00

abstract：:Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...

journal_title：Cell

authors： Ma A

更新日期：2007-10-05 00:00:00

abstract：:The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains. Expression of the gene FLO1 in the la...

journal_title：Cell

authors： Smukalla S,Caldara M,Pochet N,Beauvais A,Guadagnini S,Yan C,Vinces MD,Jansen A,Prevost MC,Latgé JP,Fink GR,Foster KR,Verstrepen KJ

更新日期：2008-11-14 00:00:00

abstract：:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...

journal_title：Cell

authors： Clapham DE

更新日期：2009-03-06 00:00:00

abstract：:Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...

journal_title：Cell

authors： Rehman SK,Haynes J,Collignon E,Brown KR,Wang Y,Nixon AML,Bruce JP,Wintersinger JA,Singh Mer A,Lo EBL,Leung C,Lima-Fernandes E,Pedley NM,Soares F,McGibbon S,He HH,Pollet A,Pugh TJ,Haibe-Kains B,Morris Q,Ramalho-San

更新日期：2021-01-07 00:00:00

abstract：:X-linked lissencephaly and "double cortex" are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Dou...

journal_title：Cell

authors： Gleeson JG,Allen KM,Fox JW,Lamperti ED,Berkovic S,Scheffer I,Cooper EC,Dobyns WB,Minnerath SR,Ross ME,Walsh CA

更新日期：1998-01-09 00:00:00

abstract：:Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG an...

journal_title：Cell

authors： Horsley V,O'Carroll D,Tooze R,Ohinata Y,Saitou M,Obukhanych T,Nussenzweig M,Tarakhovsky A,Fuchs E

更新日期：2006-08-11 00:00:00

abstract：:We wished to learn whether the genomes of strains of EMB isolated from patients with infectious mononucleosis are consistently distinguishable from those of strains from Burkitt's lymphoma. The genome of a new transforming strains (FF41) of EBV isolated from saliva of a patient with uncomplicated infectious mononucleo...

journal_title：Cell

authors： Fischer DK,Miller G,Gradoville L,Heston L,Westrate MW,Maris W,Wright J,Brandsma J,Summers WC

更新日期：1981-05-01 00:00:00

abstract：:Minimal hammerhead ribozymes have been characterized extensively by static and time-resolved crystallography as well as numerous biochemical analyses, leading to mutually contradictory mechanistic explanations for catalysis. We present the 2.2 A resolution crystal structure of a full-length Schistosoma mansoni hammerh...

journal_title：Cell

authors： Martick M,Scott WG

更新日期：2006-07-28 00:00:00

abstract：:The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...

journal_title：Cell

authors： Pauluzzi G,Bailey-Serres J

更新日期：2016-01-28 00:00:00

abstract：:To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expression in six rodents. Despite an overall fast turnover of TF binding location...

journal_title：Cell

authors： Stefflova K,Thybert D,Wilson MD,Streeter I,Aleksic J,Karagianni P,Brazma A,Adams DJ,Talianidis I,Marioni JC,Flicek P,Odom DT

更新日期：2013-08-01 00:00:00

abstract：:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The re...

journal_title：Cell

authors： Nose A,Tsuji K,Takeichi M

更新日期：1990-04-06 00:00:00

abstract：:Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory cha...

journal_title：Cell

authors： Takeoka A,Vollenweider I,Courtine G,Arber S

更新日期：2014-12-18 00:00:00

abstract：:Specification of the germ cell lineage is vital to development and heredity. In mice, the germ cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying mechanism remains unknown. Here we demonstrate that germ cell fate in the epiblast is a direct consequence of Bmp4 signaling from ...

journal_title：Cell

authors： Ohinata Y,Ohta H,Shigeta M,Yamanaka K,Wakayama T,Saitou M

更新日期：2009-05-01 00:00:00

abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...

journal_title：Cell

authors： Malhotra V

更新日期：2012-03-30 00:00:00

abstract：:Ions serve as essential nutrients in higher plants and can also act as signaling molecules. Little is known about how plants sense changes in soil nutrient concentrations. Previous studies showed that T101-phosphorylated CHL1 is a high-affinity nitrate transporter, whereas T101-dephosphorylated CHL1 is a low-affinity ...

journal_title：Cell

authors： Ho CH,Lin SH,Hu HC,Tsay YF

更新日期：2009-09-18 00:00:00

abstract：:We have sequenced HFL1 from D. melanogaster, the only cloned hobo element shown to have transposase activity. The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum ma...

journal_title：Cell

authors： Calvi BR,Hong TJ,Findley SD,Gelbart WM

更新日期：1991-08-09 00:00:00

abstract：:Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed i...

journal_title：Cell

authors： Schaffer JE,Lodish HF

更新日期：1994-11-04 00:00:00

abstract：:Bovine Papilloma Virus (BPV-1) establishes itself as a multicopy nuclear plasmid in somatic mammalian cells in culture. We report here that two discontinuous regions within the viral genome can independently support extrachromosomal replication of the Tn5 neomycinr gene in cells that provide viral factors in trans. Th...

journal_title：Cell

authors： Lusky M,Botchan MR

更新日期：1984-02-01 00:00:00

abstract：:Cytokine-activated receptors initiate intracellular signaling by recruiting protein kinases that phosphorylate the receptors on tyrosine residues, thus enabling docking of SH2 domain-bearing activating factors. Here we report that in response to type 1 interferon (IFNalpha), IFNalpha receptors recruit cytoplasmic CREB...

journal_title：Cell

authors： Tang X,Gao JS,Guan YJ,McLane KE,Yuan ZL,Ramratnam B,Chin YE

更新日期：2007-10-05 00:00:00

abstract：:We describe the identification and characterization of the Saccharomyces cerevisiae ZIP2 gene, which encodes a novel meiosis-specific protein essential for synaptonemal complex formation. In the zip2 mutant, chromosomes are homologously paired but not synapsed. The Zip2 protein localizes to discrete foci on meiotic ch...

journal_title：Cell

authors： Chua PR,Roeder GS

更新日期：1998-05-01 00:00:00

abstract：:Drosophila Reaper (RPR), Head Involution Defective (HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1. Here we show that HID blocks DIAP1's ability to inhibit caspase activity and provide evidence suggesting that RPR and GRIM can act similarly. Based on thes...

journal_title：Cell

authors： Wang SL,Hawkins CJ,Yoo SJ,Müller HA,Hay BA

更新日期：1999-08-20 00:00:00

abstract：:Voltage-gated calcium channels play a central role in regulating the electrical and biochemical properties of neurons and muscle cells. One of the ways in which calcium channels regulate long-lasting neuronal properties is by activating signaling pathways that control gene expression, but the mechanisms that link calc...

journal_title：Cell

authors： Gomez-Ospina N,Tsuruta F,Barreto-Chang O,Hu L,Dolmetsch R

更新日期：2006-11-03 00:00:00

abstract：:We have compared the chromatin structure in the active and inactive states at loci encoding the major heat shock protein in Drosophila. DNAase I and micrococcal nuclease were used as probes of higher order organization and nucleosomal integrity. Such integrity is gauged here by the characteristic pattern of discrete D...

journal_title：Cell

authors： Wu C,Wong YC,Elgin SC

更新日期：1979-04-01 00:00:00

abstract：:Most gram-negative pathogens express fibrous adhesive virulence organelles that mediate targeting to the sites of infection. The F1 capsular antigen from the plague pathogen Yersinia pestis consists of linear fibers of a single subunit (Caf1) and serves as a prototype for nonpilus organelles assembled via the chaperon...

journal_title：Cell

authors： Zavialov AV,Berglund J,Pudney AF,Fooks LJ,Ibrahim TM,MacIntyre S,Knight SD

更新日期：2003-05-30 00:00:00

abstract：:We have isolated spontaneous temperature-resistant revertants of a temperature-sensitive mutation (rpoD800) in the sigma subunit of E. coli K12 RNA polymerase. These revertants still contained the rpoD800 allele. They were mucoid, and sensitive to ultraviolet light and the radiomimetic agent nitrofurantoin, which are ...

journal_title：Cell

authors： Grossman AD,Burgess RR,Walter W,Gross CA

更新日期：1983-01-01 00:00:00

abstract：:In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceru...

journal_title：Cell

authors： Schimmel P,Ewalt K

更新日期：2004-10-15 00:00:00

abstract：:Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain po...

journal_title：Cell

authors： Blackledge NP,Farcas AM,Kondo T,King HW,McGouran JF,Hanssen LLP,Ito S,Cooper S,Kondo K,Koseki Y,Ishikura T,Long HK,Sheahan TW,Brockdorff N,Kessler BM,Koseki H,Klose RJ

更新日期：2014-06-05 00:00:00

abstract：:The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that dispe...

journal_title：Cell

authors： Greco V,Hannus M,Eaton S

更新日期：2001-09-07 00:00:00

abstract：:Drosophila chorion genes are located in two clusters, one on the X chromosome at 7F1-2 of the polytene chromosome map and a second on the third chromosome at 66D11-15. Genes in both regions undergo amplification in ovarian follicle cells prior to their expression late in oogenesis. Analysis of cloned genomic segments ...

journal_title：Cell

authors： Spradling AC

更新日期：1981-11-01 00:00:00