Abstract:
:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The results showed that the amino-terminal 113 amino acid region is essential to determine the specificities, and within this region we could identify especially important sites in which amino acid substitutions altered the binding specificity of cadherins. We also found that the epitopes for antibodies capable of blocking cadherin action are located in this amino-terminal region.
journal_name
Celljournal_title
Cellauthors
Nose A,Tsuji K,Takeichi Mdoi
10.1016/0092-8674(90)90222-zsubject
Has Abstractpub_date
1990-04-06 00:00:00pages
147-55issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(90)90222-Zjournal_volume
61pub_type
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