Localization of specificity determining sites in cadherin cell adhesion molecules.

Abstract:

:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The results showed that the amino-terminal 113 amino acid region is essential to determine the specificities, and within this region we could identify especially important sites in which amino acid substitutions altered the binding specificity of cadherins. We also found that the epitopes for antibodies capable of blocking cadherin action are located in this amino-terminal region.

journal_name

Cell

journal_title

Cell

authors

Nose A,Tsuji K,Takeichi M

doi

10.1016/0092-8674(90)90222-z

subject

Has Abstract

pub_date

1990-04-06 00:00:00

pages

147-55

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(90)90222-Z

journal_volume

61

pub_type

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